PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MLOC_11415.2
Organism
Hordeum vulgare
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; BOP clade; Pooideae; Triticodae; Triticeae; Hordeinae; Hordeum
Family E2F/DP
Protein Properties Length: 445aa    MW: 48755.7 Da    PI: 4.4615
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MLOC_11415.2genomeIBSCView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP81.95.4e-26131196171
       E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                   r+++sL+llt+kfl+ll+ ++ g+v+ln++a+ L   +v  ++RRiYDi+NVLe+++liekk kn+irwkg
  MLOC_11415.2 131 RYDSSLGLLTKKFLNLLKGAPGGMVDLNNAAEML---EV--QKRRIYDITNVLEGIGLIEKKLKNNIRWKG 196
                   6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.108.3E-28129197IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.77E-16131194IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.3E-34131196IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.3E-23133196IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146601.24E-48207313No hitNo description
SuperFamilySSF1440749.15E-33208313No hitNo description
PfamPF164211.1E-32212311IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 445 aa     Download sequence    Send to blast
MAAAGGGTSS EGAARVLLQR YQPFGSPPGE YHHFGPADGG ASAEMTEAVV LRTPLKRKHN  60
REGNEVAESN DWMMSPGYAN AGNSPIPTPP SGKGTKLSAK PKAVKGQKSC PQTPLFSGSP  120
GNPATPVGGC RYDSSLGLLT KKFLNLLKGA PGGMVDLNNA AEMLEVQKRR IYDITNVLEG  180
IGLIEKKLKN NIRWKGIDDS RPGEVSDDMS ILQGDIEALT LQEHSLDRQI SEMRDRLREL  240
TEDENNQKWL YVTEDDIKSL PCFQNQTLIA IKAPHGTTLE VPDPDEVNDY PQRRYRTVLR  300
STMGPIDVYL VSQFEEMSGM ETPPRPAQTI NMDSLENPRT PLSAGSNKDV EMENVQQGLI  360
IPSDAPTTSQ DIGGMMKIVP SELDTDADYW LLSDTGVSIT DMWKTTPDVE WDGIDINTED  420
FLEVGTPRQQ DQLPSDMVDH PSCIS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A7e-22123197274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapMLOC_11415.2
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_020177970.10.0transcription factor E2FA-like
SwissprotQ9FNY01e-121E2FA_ARATH; Transcription factor E2FA
TrEMBLM0UJ340.0M0UJ34_HORVV; Uncharacterized protein
STRINGMLOC_11415.20.0(Hordeum vulgare)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MonocotsOGMP62537148
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-114E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]