PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis

Family

E2F/DP

Protein Properties

Length: 356aa MW: 39872.8 Da PI: 4.6901

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
MELO3C024578P1	genome	MELONOMICS	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	81.7	6.4e-26	70	135	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l++++++gi++ln++a++L +v ++RRiYDi+NVLe+++liekk kn i wkg MELO3C024578P1 70 RYDSSLGLLTKKFINLIKQARDGILDLNKAAETL---QV--QKRRIYDITNVLEGIGLIEKKLKNIIYWKG 135 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	3.5E-28	67	137	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	3.1E-31	70	135	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	2.65E-17	70	133	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	1.7E-23	72	135	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF144074	1.07E-32	149	252	No hit	No description
Pfam	PF16421	9.7E-32	151	250	IPR032198	E2F transcription factor, CC-MB domain
CDD	cd14660	7.87E-45	151	252	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 356 aa Download sequence Send to blast
MYNNVVKSND YIHDEGSSKD ALSCVQTPVS AKGGRAYNKS KTSRKTTSGP QTPISDTSTY 60 SPLTPAGNCR YDSSLGLLTK KFINLIKQAR DGILDLNKAA ETLQVQKRRI YDITNVLEGI 120 GLIEKKLKNI IYWKGFNQQI PGNVDSDASM LQVDVENLSF EERRLDDKIR AMQERLRNLS 180 EDENIQKWLF VTEDDIKNLP CFQNETLIAI KAPHGTTLEV PDPDEAVDYP QRRYRIVLRS 240 TMGPIDVYLV SQFEEKFEEM NVVQPPSSFL HASSSGSNEH LATEAIIGES SRNEIEPLAH 300 LSQHSSSCDV NGSNEFPGGM MKILPSDIDN DADYWLLSDA EVSITDMWRT DCILI*

Sequence ? help Back to Top

Protein Sequence Length: 356 aa Download sequence Send to blast

MYNNVVKSND YIHDEGSSKD ALSCVQTPVS AKGGRAYNKS KTSRKTTSGP QTPISDTSTY  60
SPLTPAGNCR YDSSLGLLTK KFINLIKQAR DGILDLNKAA ETLQVQKRRI YDITNVLEGI  120
GLIEKKLKNI IYWKGFNQQI PGNVDSDASM LQVDVENLSF EERRLDDKIR AMQERLRNLS  180
EDENIQKWLF VTEDDIKNLP CFQNETLIAI KAPHGTTLEV PDPDEAVDYP QRRYRIVLRS  240
TMGPIDVYLV SQFEEKFEEM NVVQPPSSFL HASSSGSNEH LATEAIIGES SRNEIEPLAH  300
LSQHSSSCDV NGSNEFPGGM MKILPSDIDN DADYWLLSDA EVSITDMWRT DCILI*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	2e-24	62	135	2	73	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
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Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	LN681876	1e-129	LN681876.1 Cucumis melo genomic scaffold, anchoredscaffold00068.
GenBank	LN713262	1e-129	LN713262.1 Cucumis melo genomic chromosome, chr_8.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_016902873.1	0.0	PREDICTED: transcription factor E2FA-like isoform X2
Swissprot	Q9FNY0	1e-135	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A1S4E3R8	0.0	A0A1S4E3R8_CUCME; transcription factor E2FA-like isoform X2
STRING	XP_008462611.1	0.0	(Cucumis melo)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF1947	34	90

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-139	E2F transcription factor 3

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]