PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MELO3C017127P1
Organism
Cucumis melo
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis
Family E2F/DP
Protein Properties Length: 374aa    MW: 42317.8 Da    PI: 9.8213
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MELO3C017127P1genomeMELONOMICSView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP74.41.2e-231984171
         E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                    rk+ksL+ll+++fl+l+ + + + ++l+++a++L    v  +rRRiYDi+NVLe+++++ +k+kn++rw+g
  MELO3C017127P1 19 RKQKSLGLLCSNFLRLYDRDDIQLISLDNAASRL---GV--ERRRIYDIVNVLESVGILCRKAKNQYRWIG 84
                    79****************9999************...**..****************************98 PP
2E2F_TDP73.71.9e-23149229171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                     r+eksL lltq+f+kl+ +s++  ++l+e+ak L+ +      ++ k+RR+YDi+NVL al+liek     ++k++++w g
  MELO3C017127P1 149 RREKSLALLTQNFVKLFVCSSAHLISLDEAAKLLLGDgqnvsIMRSKVRRLYDIANVLAALHLIEKtqtdgTRKPAFKWLG 229
                     689**************************************9999*************************99*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.104.7E-261585IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467859.53E-161883IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013727.7E-271984IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023196.5E-212084IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.104.2E-21147230IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013729.1E-28149229IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023195.6E-18151229IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467853.67E-12151230IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 374 aa     Download sequence    Send to blast
MAANLHLPVP DSSSNAYSRK QKSLGLLCSN FLRLYDRDDI QLISLDNAAS RLGVERRRIY  60
DIVNVLESVG ILCRKAKNQY RWIGYSGIPK ALRQLKEEDS KGNSSAIDAN DRSSLIDDEE  120
ETCSDLTSVS HDSISVISKS STSVRCENRR EKSLALLTQN FVKLFVCSSA HLISLDEAAK  180
LLLGDGQNVS IMRSKVRRLY DIANVLAALH LIEKTQTDGT RKPAFKWLGW RSLVENCRAG  240
KLIRCDSNKR SFGSDITNNN LKRNRMPYSF DLNKSPNSQQ QRHVQLEGCG VEVTGDDLER  300
DLNSKSFKFG PFSPSVRVEA RASKIEAKQS RNNWVSLAST YRPQYQNQAL RELFSHYKEA  360
WNLWYSEKKK TNP*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A3e-32182233232Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankLN6818130.0LN681813.1 Cucumis melo genomic scaffold, anchoredscaffold00030.
GenBankLN7132560.0LN713256.1 Cucumis melo genomic chromosome, chr_2.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008453138.10.0PREDICTED: E2F transcription factor-like E2FE isoform X2
SwissprotQ8LSZ41e-107E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A1S3BVI30.0A0A1S3BVI3_CUCME; E2F transcription factor-like E2FE isoform X2
STRINGXP_008453137.10.0(Cucumis melo)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF36683366
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.22e-99DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]