PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis

Family

C2H2

Protein Properties

Length: 451aa MW: 49170.1 Da PI: 8.9071

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
MELO3C015315P2	genome	MELONOMICS	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	16.2	3e-05	77	99	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 + C++C+k F r nL+ H r H MELO3C015315P2 77 FMCEICNKGFQRDQNLQLHRRGH 99 89*******************88 PP
2	zf-C2H2	16	3.4e-05	154	176	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 +kC++C+k + +s+Lk H + + MELO3C015315P2 154 WKCEKCSKKYAVQSDLKAHTKAC 176 58*****************9876 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF57667	3.27E-8	76	99	No hit	No description
Gene3D	G3DSA:3.30.160.60	1.9E-5	76	99	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profile	PS50157	10.99	77	99	IPR007087	Zinc finger, C2H2
Pfam	PF12171	5.6E-5	77	99	IPR022755	Zinc finger, double-stranded RNA binding
SMART	SM00355	0.031	77	99	IPR015880	Zinc finger, C2H2-like
PROSITE pattern	PS00028	0	79	99	IPR007087	Zinc finger, C2H2
SMART	SM00355	97	119	149	IPR015880	Zinc finger, C2H2-like
Gene3D	G3DSA:3.30.160.60	3.7E-5	142	174	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamily	SSF57667	3.27E-8	149	174	No hit	No description
PROSITE profile	PS50157	8.6	154	182	IPR007087	Zinc finger, C2H2
SMART	SM00355	58	154	174	IPR015880	Zinc finger, C2H2-like

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003676	Molecular Function	nucleic acid binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 451 aa Download sequence Send to blast
MSKISGCSDD GGSFVSEAEK LENQFINGSF ESHHQQQQQQ QPQLVVPKKK RNLPGTPVPD 60 AEVVALSPET LMATNRFMCE ICNKGFQRDQ NLQLHRRGHN LPWKLKQRTS GSETKRKVYV 120 CPEASCVHHD PGRALGDLTG IKKHFSRKHG EKKWKCEKCS KKYAVQSDLK AHTKACGSKE 180 YKCDCGTIFS RRDSFITHRA FCDALAEEHN KLLIAHQGST TTMAAAASST AINNGPSFQP 240 QPLSHLLSRP SILPLPLTTL PHDLMPIPPK PLNLSAGSMF SSSISNNSTT TTTTFQNDNH 300 LFPSSSALMS ATALLQKAAQ MGAAVSSGGN SSAPCFNSSM IHEKKGFVTT MAPSSFCGLL 360 ATNCLQRCPQ ENMLSQLPSK GKAMEMEMMI VNNDIPMMNG VFDQPSSLVE AARKKMTLDL 420 LGDEGGNNKG MKFQAQDQSS VGLLEGLWRI *

Sequence ? help Back to Top

Protein Sequence Length: 451 aa Download sequence Send to blast

MSKISGCSDD GGSFVSEAEK LENQFINGSF ESHHQQQQQQ QPQLVVPKKK RNLPGTPVPD  60
AEVVALSPET LMATNRFMCE ICNKGFQRDQ NLQLHRRGHN LPWKLKQRTS GSETKRKVYV  120
CPEASCVHHD PGRALGDLTG IKKHFSRKHG EKKWKCEKCS KKYAVQSDLK AHTKACGSKE  180
YKCDCGTIFS RRDSFITHRA FCDALAEEHN KLLIAHQGST TTMAAAASST AINNGPSFQP  240
QPLSHLLSRP SILPLPLTTL PHDLMPIPPK PLNLSAGSMF SSSISNNSTT TTTTFQNDNH  300
LFPSSSALMS ATALLQKAAQ MGAAVSSGGN SSAPCFNSSM IHEKKGFVTT MAPSSFCGLL  360
ATNCLQRCPQ ENMLSQLPSK GKAMEMEMMI VNNDIPMMNG VFDQPSSLVE AARKKMTLDL  420
LGDEGGNNKG MKFQAQDQSS VGLLEGLWRI *

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5b3h_C	1e-31	150	212	3	65	Zinc finger protein JACKDAW
5b3h_F	1e-31	150	212	3	65	Zinc finger protein JACKDAW
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor that acts as a positive regulator of gibberellin (GA) action, homeostasis and signaling. GA converts the GAF1 complex from transcriptional activator to repressor via the degradation of DELLA proteins. {ECO:0000269\|PubMed:25035403}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	LN681806	0.0	LN681806.1 Cucumis melo genomic scaffold, anchoredscaffold00025.
GenBank	LN713256	0.0	LN713256.1 Cucumis melo genomic chromosome, chr_2.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_008450641.1	0.0	PREDICTED: protein indeterminate-domain 12-like
Swissprot	Q9SCQ6	1e-104	IDD2_ARATH; Zinc finger protein GAI-ASSOCIATED FACTOR 1
TrEMBL	A0A1S3BPM3	0.0	A0A1S3BPM3_CUCME; protein indeterminate-domain 12-like
STRING	XP_008450641.1	0.0	(Cucumis melo)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF2192	30	85

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G66730.1	3e-90	C2H2-like zinc finger protein

Publications ? help Back to Top
Fukazawa J, et al. DELLAs function as coactivators of GAI-ASSOCIATED FACTOR1 in regulation of gibberellin homeostasis and signaling in Arabidopsis. Plant Cell, 2014. 26(7): p. 2920-38 [PMID:25035403] Moreno-Risueno MA, et al. Transcriptional control of tissue formation throughout root development. Science, 2015. 350(6259): p. 426-30 [PMID:26494755] Khare D, et al. Root avoidance of toxic metals requires the GeBP-LIKE 4 transcription factor in Arabidopsis thaliana. New Phytol., 2017. 213(3): p. 1257-1273 [PMID:27768815]