PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis

Family

C2H2

Protein Properties

Length: 312aa MW: 35745.9 Da PI: 8.3684

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
MELO3C012480P1	genome	MELONOMICS	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	18.2	7.1e-06	22	42	3	23
ETTTTEEESSHHHHHHHHHHT CS zf-C2H2 3 CpdCgksFsrksnLkrHirtH 23 C+ Cg F+ + +Lk+H+++H MELO3C012480P1 22 CQQCGAAFRKPAYLKQHMQSH 42 *******************99 PP
2	zf-C2H2	17.1	1.5e-05	48	72	1	23
EEET..TTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCp..dCgksFsrksnLkrHirtH 23 y+C+ C+ s++rk++L+rH+ H MELO3C012480P1 48 YVCSidGCNASYRRKDHLTRHLLHH 72 99*******************9987 PP
3	zf-C2H2	18.3	6.5e-06	115	139	1	23
EEET..TTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCp..dCgksFsrksnLkrHirtH 23 ++Cp Cgk+F+ s L++H +H MELO3C012480P1 115 FVCPedGCGKVFRYASRLQKHEGSH 139 89*******************8666 PP
4	zf-C2H2	20.5	1.2e-06	208	231	3	23
ET..TTTEEESSHHHHHHHHHH.T CS zf-C2H2 3 Cp..dCgksFsrksnLkrHirt.H 23 C+ C+k+Fs+ snL++H ++ H MELO3C012480P1 208 CTyeGCSKVFSTASNLQQHTKVvH 231 88889***************9988 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF57667	2.19E-10	19	72	No hit	No description
PROSITE profile	PS50157	11.863	20	47	IPR007087	Zinc finger, C2H2
SMART	SM00355	0.017	20	42	IPR015880	Zinc finger, C2H2-like
PROSITE pattern	PS00028	0	22	42	IPR007087	Zinc finger, C2H2
Gene3D	G3DSA:3.30.160.60	4.2E-8	22	47	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SMART	SM00355	0.0027	48	72	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	9.598	48	77	IPR007087	Zinc finger, C2H2
Gene3D	G3DSA:3.30.160.60	9.7E-10	48	74	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE pattern	PS00028	0	50	72	IPR007087	Zinc finger, C2H2
SuperFamily	SSF57667	9.34E-5	58	113	No hit	No description
SMART	SM00355	5.9	77	102	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	11.697	77	107	IPR007087	Zinc finger, C2H2
PROSITE pattern	PS00028	0	79	102	IPR007087	Zinc finger, C2H2
Gene3D	G3DSA:3.30.160.60	2.3E-8	110	139	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamily	SSF57667	2.17E-5	112	140	No hit	No description
SMART	SM00355	6.8E-4	115	139	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	10.762	115	144	IPR007087	Zinc finger, C2H2
PROSITE pattern	PS00028	0	117	139	IPR007087	Zinc finger, C2H2
SMART	SM00355	0.55	147	172	IPR015880	Zinc finger, C2H2-like
PROSITE pattern	PS00028	0	149	172	IPR007087	Zinc finger, C2H2
Gene3D	G3DSA:3.30.160.60	4.7E-4	149	170	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SMART	SM00355	5.6	175	197	IPR015880	Zinc finger, C2H2-like
SuperFamily	SSF57667	1.94E-8	187	243	No hit	No description
PROSITE profile	PS50157	13.588	206	236	IPR007087	Zinc finger, C2H2
SMART	SM00355	0.0012	206	231	IPR015880	Zinc finger, C2H2-like
Gene3D	G3DSA:3.30.160.60	1.5E-7	208	233	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE pattern	PS00028	0	208	231	IPR007087	Zinc finger, C2H2
Gene3D	G3DSA:3.30.160.60	6.5E-5	234	259	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SMART	SM00355	11	237	262	IPR015880	Zinc finger, C2H2-like
PROSITE pattern	PS00028	0	239	263	IPR007087	Zinc finger, C2H2

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0005730	Cellular Component	nucleolus
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0008097	Molecular Function	5S rRNA binding
GO:0046872	Molecular Function	metal ion binding
GO:0080084	Molecular Function	5S rDNA binding

Sequence ? help Back to Top
Protein Sequence Length: 312 aa Download sequence Send to blast
MEIDKHNDEG DDKTKYGKLN ICQQCGAAFR KPAYLKQHMQ SHSLERSYVC SIDGCNASYR 60 RKDHLTRHLL HHQGTMFKCP IESCCREFAY LSCVTRHLKE CHEGEAPPEE CQKQFVCPED 120 GCGKVFRYAS RLQKHEGSHV KLDSIEACCT EPGCLKTFTN KQCLRAHMQT CHQYVKCEIC 180 GEKKLRKNLK QHLRQKHESE GPLEAIPCTY EGCSKVFSTA SNLQQHTKVV HLGQKPFACC 240 FPGCGMRFGY KHVRDNHEKS GHHVYTNGDF EAADEQFRSK PRGGRKRICP TVEMLIRKRV 300 TPPSDLDFMM E*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5v3m_C	1e-13	22	271	64	314	Zinc finger protein 568
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Essential protein (PubMed:22353599). Isoform 1 is a transcription activator the binds both 5S rDNA and 5S rRNA and stimulates the transcription of 5S rRNA gene (PubMed:12711688, PubMed:22353599). Isoform 1 regulates 5S rRNA levels during development (PubMed:22353599). {ECO:0000269\|PubMed:12711688, ECO:0000269\|PubMed:22353599}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00229	DAP	Transfer from AT1G72050	Download

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	LN681896	1e-158	LN681896.1 Cucumis melo genomic scaffold, anchoredscaffold00016.
GenBank	LN713264	1e-158	LN713264.1 Cucumis melo genomic chromosome, chr_10.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_008446968.1	0.0	PREDICTED: transcription factor IIIA
Swissprot	Q84MZ4	1e-117	TF3A_ARATH; Transcription factor IIIA
TrEMBL	A0A1S3BH74	0.0	A0A1S3BH74_CUCME; transcription factor IIIA
STRING	XP_008446968.1	0.0	(Cucumis melo)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF3069	33	70

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G72050.2	1e-119	transcription factor IIIA