PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis

Family

E2F/DP

Protein Properties

Length: 155aa MW: 17528.7 Da PI: 9.8631

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
MELO3C011003P1	genome	MELONOMICS	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	83.8	1.4e-26	50	115	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+ lt+kf++l++++e+g+++ln+ a+ L +v ++RRiYDi+NVLe+++liek+ n+irwkg MELO3C011003P1 50 RYDSSLGFLTKKFISLVQEAEDGTLDLNKTADVL---KV--QKRRIYDITNVLEGIGLIEKTTTNHIRWKG 115 6899****************************...88..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	6.3E-28	46	116	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	5.99E-18	50	113	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	1.1E-33	50	115	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	3.7E-25	52	115	IPR003316	E2F/DP family, winged-helix DNA-binding domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 155 aa Download sequence Send to blast
MRSNDSSCEP VSSANEKQNK KFKLQKNSKS KTQKSVDEPV DSPNPSTNGR YDSSLGFLTK 60 KFISLVQEAE DGTLDLNKTA DVLKVQKRRI YDITNVLEGI GLIEKTTTNH IRWKGGERRG 120 PQELNDQVGR LKDEVKSLYA DERKLDELIR NKNF*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	5e-27	45	115	2	73	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
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Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	82	88	LKVQKRR

Functional Description ? help Back to Top
Source	Description
UniProt	Involved in transcriptional repression. May act by repressing E2F-regulated genes in mature differentiated cells, but is not an antagonist of E2FA. Restricts cell division and is involved in the coordination between cell proliferation and endoreduplication during development. May play a role during the transition from skotomorphogenesis to photomorphogenesis. Regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(SKP2A) complex. {ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12468727, ECO:0000269\|PubMed:16920782, ECO:0000269\|PubMed:19662336}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Down-regulated by light. {ECO:0000269\|PubMed:12468727, ECO:0000269\|PubMed:18424613}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	LN681823	6e-55	LN681823.1 Cucumis melo genomic scaffold, anchoredscaffold00014.
GenBank	LN713257	6e-55	LN713257.1 Cucumis melo genomic chromosome, chr_3.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_008444795.1	1e-104	PREDICTED: transcription factor E2FC isoform X3
Swissprot	Q9FV70	4e-46	E2FC_ARATH; Transcription factor E2FC
TrEMBL	A0A1S3BAQ0	1e-102	A0A1S3BAQ0_CUCME; transcription factor E2FC isoform X3
STRING	XP_008444793.1	1e-103	(Cucumis melo)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF11885	25	29

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G47870.2	3e-48	E2F/DP family protein

Publications ? help Back to Top
Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325] Li B, et al. Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis. Plant Cell, 2018. 30(1): p. 178-195 [PMID:29317470] Huntley R, et al. The maize retinoblastoma protein homologue ZmRb-1 is regulated during leaf development and displays conserved interactions with G1/S regulators and plant cyclin D (CycD) proteins. Plant Mol. Biol., 1998. 37(1): p. 155-69 [PMID:9620273]