PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus

Family

C2H2

Protein Properties

Length: 669aa MW: 74123.5 Da PI: 9.9202

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
MDP0000248957	genome	GDR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	15.7	4.4e-05	312	334	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 ++Cp+Cg+sF++ ++ +H ++ MDP0000248957 312 FECPICGQSFRSEDEVSVHVDSC 334 89*****************8776 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SMART	SM00734	0.0038	311	335	IPR006642	Zinc finger, Rad18-type putative
PROSITE profile	PS50157	8.621	312	341	IPR007087	Zinc finger, C2H2
SuperFamily	SSF143503	1.27E-17	377	449	IPR018997	PUB domain
CDD	cd09212	2.28E-20	377	461	No hit	No description
SMART	SM00580	5.2E-20	379	446	IPR018997	PUB domain
Pfam	PF09409	3.2E-16	380	452	IPR018997	PUB domain
SuperFamily	SSF54236	1.03E-11	523	636	IPR029071	Ubiquitin-related domain
Gene3D	G3DSA:3.10.20.90	9.7E-8	551	636	No hit	No description
PROSITE profile	PS50033	11.324	552	636	IPR001012	UBX domain
Pfam	PF00789	8.0E-6	553	603	IPR001012	UBX domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006281	Biological Process	DNA repair
GO:0003677	Molecular Function	DNA binding
GO:0005515	Molecular Function	protein binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 669 aa Download sequence Send to blast
PEKRAAQRSD GVGVGCPRVR RCRGGDHGAP PHDPRPRRPP QGPRHCHPQP PQTVALSGAV 60 VPLLAHGHLL EVRDSPELRR RLLHSLGVPP PPEVDHEEPA QRALDRRRLD LLLAPLHRHP 120 PRCPHRAVEP ARRALEESRL NPLGKEKQKR ACEGRKAVWR GKLSNEHRLL FFFFFFQYID 180 MKDKFKGFMK NTFSSSSSGK FKGQGRVLGS SSSSGPADSV LIRPKQTPHS NPKPVPNSNS 240 NSNSSVASPN PKPSPQKTQI IHQEKAQIPD QSQAEPSFNS KPDRKTETGF DPFDALITPG 300 KRSQNGFTLN VFECPICGQS FRSEDEVSVH VDSCANTSVE NKSVEGVGVS RSPDNGSESS 360 RSELEARIGT FSSGNPAAGS VEVVLRLLRN IVKEPENVKF RRIRMSNPKI RESLGEVVGG 420 IELLEFVGFE LKEEDGEMWA VMEVPREEQI NLMKRGIALL EPPKVQEVDI SASIASLKVD 480 EPVEPRKVDR QTRVFFSVSE SVAARIEVPA SFYNLSATEL KREAEMRKKK IEDSQMLIPK 540 SFKEKQAKAA KRRYRKTVIR IQFPDGVVLQ GVFSPLEPTS SLYEYVSSAL KEPSLEFELL 600 NPVALKRRVI PHFPAAGKKA ATLADEDLMP SALVKFKPIE TDSVVFTGLC NDLLEISEPL 660 TSGSAAAPV

Sequence ? help Back to Top

Protein Sequence Length: 669 aa Download sequence Send to blast

PEKRAAQRSD GVGVGCPRVR RCRGGDHGAP PHDPRPRRPP QGPRHCHPQP PQTVALSGAV  60
VPLLAHGHLL EVRDSPELRR RLLHSLGVPP PPEVDHEEPA QRALDRRRLD LLLAPLHRHP  120
PRCPHRAVEP ARRALEESRL NPLGKEKQKR ACEGRKAVWR GKLSNEHRLL FFFFFFQYID  180
MKDKFKGFMK NTFSSSSSGK FKGQGRVLGS SSSSGPADSV LIRPKQTPHS NPKPVPNSNS  240
NSNSSVASPN PKPSPQKTQI IHQEKAQIPD QSQAEPSFNS KPDRKTETGF DPFDALITPG  300
KRSQNGFTLN VFECPICGQS FRSEDEVSVH VDSCANTSVE NKSVEGVGVS RSPDNGSESS  360
RSELEARIGT FSSGNPAAGS VEVVLRLLRN IVKEPENVKF RRIRMSNPKI RESLGEVVGG  420
IELLEFVGFE LKEEDGEMWA VMEVPREEQI NLMKRGIALL EPPKVQEVDI SASIASLKVD  480
EPVEPRKVDR QTRVFFSVSE SVAARIEVPA SFYNLSATEL KREAEMRKKK IEDSQMLIPK  540
SFKEKQAKAA KRRYRKTVIR IQFPDGVVLQ GVFSPLEPTS SLYEYVSSAL KEPSLEFELL  600
NPVALKRRVI PHFPAAGKKA ATLADEDLMP SALVKFKPIE TDSVVFTGLC NDLLEISEPL  660
TSGSAAAPV

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5ifw_A	8e-12	507	636	23	146	Tether containing UBX domain for GLUT4
Search in ModeBase

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
Mdo.3792	0.0	bud\| fruit\| leaf\| root\| stem

Functional Description ? help Back to Top
Source	Description
UniProt	Facilitates the interaction of SYP31 and CDC48A, thereby regulating an CDC48A membrane-associated function (Ref.8). Appears to act as a negative regulator mediating the powdery mildew-plant interaction (PubMed:19176722, PubMed:23301616). {ECO:0000269\|PubMed:19176722, ECO:0000269\|PubMed:23301616, ECO:0000269\|Ref.8}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Induced in response to powdery mildew and by benzothiadiazole (BTH) treatment. {ECO:0000269\|PubMed:19176722}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_028952517.1	0.0	plant UBX domain-containing protein 2-like
Swissprot	Q9ZU93	1e-174	PUX2_ARATH; Plant UBX domain-containing protein 2
TrEMBL	A0A498HN39	0.0	A0A498HN39_MALDO; Uncharacterized protein
STRING	XP_009351535.1	0.0	(Pyrus x bretschneideri)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF8944	25	29

Link Out ? help Back to Top
Phytozome	MDP0000248957

Publications ? help Back to Top
Suzuki T,Park H,Till EA,Lennarz WJ The PUB domain: a putative protein-protein interaction domain implicated in the ubiquitin-proteasome pathway. Biochem. Biophys. Res. Commun., 2001. 287(5): p. 1083-7 [PMID:11587532] Rancour DM,Park S,Knight SD,Bednarek SY Plant UBX domain-containing protein 1, PUX1, regulates the oligomeric structure and activity of arabidopsis CDC48. J. Biol. Chem., 2004. 279(52): p. 54264-74 [PMID:15498773] Chandran D,Rickert J,Cherk C,Dotson BR,Wildermuth MC Host cell ploidy underlying the fungal feeding site is a determinant of powdery mildew growth and reproduction. Mol. Plant Microbe Interact., 2013. 26(5): p. 537-45 [PMID:23301616]