PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000236500
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family HD-ZIP
Protein Properties Length: 842aa    MW: 92546.3 Da    PI: 6.612
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000236500genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox57.71.9e-182683457
                   -SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHC....TS-HHHHHHHHHHHHHHHHC CS
       Homeobox  4 RttftkeqleeLeelFeknrypsaeereeLAkkl....gLterqVkvWFqNrRakekk 57
                     ++t+eq+e+Le++++++++ps  +r++L +++    +++ rq+kvWFqNrR +ek+
  MDP0000236500 26 YVRYTSEQVEALERVYAECPKPSSLRRQQLIRECsilsNIEPRQIKVWFQNRRCREKQ 83
                   5789****************************************************97 PP
2START141.39.9e-451643932204
                    HHHHHHHHHHHHHHHC-TT-EEEEEXCCTTEEEEEEESSS.SCEEEEEEEECCSCHHH.HHHHHHCCCGG....................CT-TT- CS
          START   2 laeeaaqelvkkalaeepgWvkssesengdevlqkfeeskvdsgealrasgvvdmvla.llveellddke....................qWdetl 76 
                    +aee+++e+++ka+ ++  Wv+++ +++g++++ +f+ s+++sg a+ra+g+v  +++   + +++  ++                     W +++
  MDP0000236500 164 VAEETLAEFLSKATGTAVDWVQMPGMKPGPDSVGIFAISQSCSGVAARACGLVSLEPTkAAYFHVIRFMKhldlkliihkqiaeilkdrpSWFRDC 259
                    789**************************************9999999999999988844555555555567788999999999999999****** PP

                    SEEEEEEEECTT..EEEEEEEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--....-TTSEE-EESSEEEEEEEECTCEEEEEE CS
          START  77 akaetlevissg..galqlmvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppe...sssvvRaellpSgiliepksnghskvtw 166
                    ++ e+      g  g+++l++++++a+++l+p Rdf+++Ry+ +l  g++v++++S++     p+    s++vR+ +lpSg+li+p+++g+s v++
  MDP0000236500 260 RSLEVFTMFPAGngGTIELIYTQTYAPTTLAPaRDFWTLRYTXTLDNGSFVVCERSLSGSGAGPNpasASQFVRGAMLPSGYLIRPCEGGGSIVHI 355
                    *9999999999999********************************************988888878999************************** PP

                    EE-EE--SSXXHHHHHHHHHHHHHHHHHHHHHHTXXXX CS
          START 167 vehvdlkgrlphwllrslvksglaegaktwvatlqrqc 204
                    v+h +l++++++++lr+l++s+ + +++++ a+l++ +
  MDP0000236500 356 VDHLNLEAWSVPEVLRPLYESSKVVAQRMTIAALRYIR 393
                    *********************************99865 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5007115.3862084IPR001356Homeobox domain
SMARTSM003891.3E-162288IPR001356Homeobox domain
SuperFamilySSF466891.45E-162486IPR009057Homeodomain-like
CDDcd000861.62E-162585No hitNo description
PfamPF000464.5E-162683IPR001356Homeobox domain
Gene3DG3DSA:1.10.10.601.2E-182783IPR009057Homeodomain-like
CDDcd146864.87E-677116No hitNo description
PROSITE profilePS5084825.657154404IPR002913START domain
SMARTSM002349.7E-33163395IPR002913START domain
SuperFamilySSF559613.02E-29164397No hitNo description
PfamPF018522.2E-7164221IPR002913START domain
PfamPF018523.8E-34242393IPR002913START domain
Gene3DG3DSA:3.30.530.205.9E-17243371IPR023393START-like domain
PfamPF086702.2E-43710841IPR013978MEKHLA
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0008289Molecular Functionlipid binding
Sequence ? help Back to Top
Protein Sequence    Length: 842 aa     Download sequence    Send to blast
MAMAVAHHRE SSSGSSINKH LDAGKYVRYT SEQVEALERV YAECPKPSSL RRQQLIRECS  60
ILSNIEPRQI KVWFQNRRCR EKQRKESSRL QTVNRKLSAM NKLLMEENDR LQKQVSQLVC  120
ENGYMRQQLH XASAATTDAS GDSVVTTPQH SLRDANNPAG LLSVAEETLA EFLSKATGTA  180
VDWVQMPGMK PGPDSVGIFA ISQSCSGVAA RACGLVSLEP TKAAYFHVIR FMKHLDLKLI  240
IHKQIAEILK DRPSWFRDCR SLEVFTMFPA GNGGTIELIY TQTYAPTTLA PARDFWTLRY  300
TXTLDNGSFV VCERSLSGSG AGPNPASASQ FVRGAMLPSG YLIRPCEGGG SIVHIVDHLN  360
LEAWSVPEVL RPLYESSKVV AQRMTIAALR YIRQIAEETS GEVVYSLGRQ PAVLRTFSQR  420
LIRGFNDAVN GFNDDGWSLV NCDGDGADDV IIAVNSTKNL TSTSNHANSL ALLGGVLCAK  480
ASMLLQNVPP AVLVRFLREH RSEWADFNVD AYSATSMKAG XYAYPGMRPT RFTGGQIIMP  540
LGHTIEQEEL LEVVRLEGHS LTQEDAFASR DIHLLQICSG VDENAVGACS ELVFAPIDEM  600
FPDDAPLLPS GFRIIPLDSK TGDSKDTLNT HRTLDLTSSL EVGSTTSNAA GELTTFHNTR  660
SVLTIAFQFP FDNSLQENVA NMARQYVRSV ISSVQRVAMA ISPSGLSPYH VGGELLRPDS  720
LGGDSLLKHL WHHQDAILCC SLKSMPVFIF ANQAGLDMLE TTLVALQDIS LDKIFDESGR  780
KTLCADFAKL MNQGFAYLPA GICMSTXGRH VSYEQAIAWK VVAAEENSVH CLAFSFVNWS  840
FV
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Mdo.166090.0bud| fruit| leaf| stem
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed at the earliest stages and throughout LSM initiation and development. In embryo development, expressed at the heart stage until the 'walking stick' stage in the adaxial portion of the cotyledon primordia, the shoot apical meristem (SAM) and the vascular precursor cells of the hypocotyl and root. In developing flowers, expressed first at stage 1 in the center of L3 layer and then expands to the center of L2 and L1 layers. Expressed in the center of flower meristem through stages 4 and 5. At stage 6, expressed in the adaxial side of the carpel primordia and then on the adaxial carpel face. {ECO:0000269|PubMed:11169198}.
UniprotTISSUE SPECIFICITY: Expressed in the interfascicular regions of stem and vascular bundles of young roots and leaves. {ECO:0000269|PubMed:10559440}.
Functional Description ? help Back to Top
Source Description
UniProtProbable transcription factor involved in the regulation of interfascicular fiber (cortical cells) and secondary xylem differentiation in the inflorescence stems. Required for lateral shoot meristems (LSMs) and flower meristems (FMs) initiation. May be involved in the determination of vascular patterning and organ polarity (PubMed:10559440, PubMed:11169198, PubMed:11402186, PubMed:15111711, PubMed:15598805, PubMed:7555701). Directly regulates the expression of AGO10, ZPR1, ZPR2, ZPR3 and ZPR4 (PubMed:22781836). Required to regulate adaxial-abaxial polarity and leaf axial patterning (PubMed:20807212). {ECO:0000269|PubMed:10559440, ECO:0000269|PubMed:11169198, ECO:0000269|PubMed:11402186, ECO:0000269|PubMed:15111711, ECO:0000269|PubMed:15598805, ECO:0000269|PubMed:20807212, ECO:0000269|PubMed:22781836, ECO:0000269|PubMed:7555701}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By auxin. Repressed by ZPR and miR165. Induced by DOF5.1 (PubMed:20807212). {ECO:0000269|PubMed:15111711, ECO:0000269|PubMed:17237362, ECO:0000269|PubMed:20807212}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankFJ1774250.0FJ177425.1 Malus x domestica putative REV HD-ZipIII mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001315783.10.0homeobox-leucine zipper protein REVOLUTA-like
SwissprotQ9SE430.0REV_ARATH; Homeobox-leucine zipper protein REVOLUTA
TrEMBLB6DXL60.0B6DXL6_MALDO; Putative REV HD-ZipIII
STRINGXP_008359130.10.0(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF66333147
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G60690.10.0HD-ZIP family protein
Publications ? help Back to Top
  1. Varkonyi-Gasic E,Gould N,Sandanayaka M,Sutherland P,MacDiarmid RM
    Characterisation of microRNAs from apple (Malus domestica 'Royal Gala') vascular tissue and phloem sap.
    BMC Plant Biol., 2010. 10: p. 159
    [PMID:20682080]
  2. Lian H,Li X,Liu Z,He Y
    HYL1 is required for establishment of stamen architecture with four microsporangia in Arabidopsis.
    J. Exp. Bot., 2013. 64(11): p. 3397-410
    [PMID:23918970]
  3. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  4. Baima S, et al.
    Negative feedback regulation of auxin signaling by ATHB8/ACL5-BUD2 transcription module.
    Mol Plant, 2014. 7(6): p. 1006-1025
    [PMID:24777988]
  5. Jia X, et al.
    Functional plasticity of miR165/166 in plant development revealed by small tandem target mimic.
    Plant Sci., 2015. 233: p. 11-21
    [PMID:25711809]
  6. Roodbarkelari F,Du F,Truernit E,Laux T
    ZLL/AGO10 maintains shoot meristem stem cells during Arabidopsis embryogenesis by down-regulating ARF2-mediated auxin response.
    BMC Biol., 2015. 13: p. 74
    [PMID:26358077]
  7. Shi B, et al.
    Two-Step Regulation of a Meristematic Cell Population Acting in Shoot Branching in Arabidopsis.
    PLoS Genet., 2016. 12(7): p. e1006168
    [PMID:27398935]