PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000005879
Common NameLOC103441156
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family HD-ZIP
Protein Properties Length: 829aa    MW: 91335.2 Da    PI: 6.15
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000005879genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox51.51.7e-16563356
                   --SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHC....TS-HHHHHHHHHHH.HHHHH CS
       Homeobox  3 kRttftkeqleeLeelFeknrypsaeereeLAkkl....gLterqVkvWFqNr.Rakek 56
                   k  ++t+eq+e+Le+l++++++ps  +r++L +++    +++ +q+kvWFqNr R +ek
  MDP0000005879  5 KYVRYTPEQVEALERLYHECPKPSSMRRQQLIRECpilsNIEPKQIKVWFQNRsRCREK 63
                   5679************************************************9766666 PP
2START1848.2e-581543622205
                    HHHHHHHHHHHHHHHC-TT-EEEEEXCCTTEEEEEEESSS.SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT-SEEEEEEEECTT..EEEEEEE CS
          START   2 laeeaaqelvkkalaeepgWvkssesengdevlqkfeeskvdsgealrasgvvdmvlallveellddkeqWdetlakaetlevissg..galqlmv 95 
                    +aee+++e+++ka+ ++  Wv+++ +++g++++ +++ s++++g a+ra+g+v  +++  v+e+l+d++ W ++++++++l+v+s+g  g+++l +
  MDP0000005879 154 IAEETLAEFLSKATGTAVEWVQLPGMKPGPDSIGIVAISHGCTGVAARACGLVGLDPT-RVAEILKDRPSWFRNCRSVDVLNVLSTGngGTIELLY 248
                    7899******************************************************.8888888888*************************** PP

                    EXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--....-TTSEE-EESSEEEEEEEECTCEEEEEEEE-EE--SSXXHHHHHHHHHH CS
          START  96 aelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppe...sssvvRaellpSgiliepksnghskvtwvehvdlkgrlphwllrslvks 187
                    ++l+a+++l+p Rdf+ +Ry+  l++g++v++++S++++q+ p+    +++vRae+lpSg+li+p+++g+s +++v+h+dl+ ++++++lr+l++s
  MDP0000005879 249 MQLYAPTTLAPaRDFWLLRYTSVLEDGSLVVCERSLNNTQNGPSmppVQNFVRAEMLPSGYLIRPCEGGGSILHIVDHMDLEPWSVPEVLRPLYES 344
                    ******************************************9988899*********************************************** PP

                    HHHHHHHHHHHHTXXXXX CS
          START 188 glaegaktwvatlqrqce 205
                    ++  ++kt++a+l+++++
  MDP0000005879 345 STLLAQKTTMAALRNLRQ 362
                    **************9876 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5007113.734164IPR001356Homeobox domain
SMARTSM003894.9E-12269IPR001356Homeobox domain
SuperFamilySSF466896.84E-14567IPR009057Homeodomain-like
CDDcd000862.25E-15566No hitNo description
PfamPF000463.8E-14663IPR001356Homeobox domain
Gene3DG3DSA:1.10.10.604.6E-16764IPR009057Homeodomain-like
CDDcd146862.93E-65597No hitNo description
PROSITE profilePS5084826.515144372IPR002913START domain
CDDcd088754.31E-81148363No hitNo description
SMARTSM002343.4E-44153363IPR002913START domain
Gene3DG3DSA:3.30.530.207.2E-25153360IPR023393START-like domain
SuperFamilySSF559617.97E-40153365No hitNo description
PfamPF018522.7E-55154362IPR002913START domain
PfamPF086703.0E-52688828IPR013978MEKHLA
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010067Biological Processprocambium histogenesis
GO:0010072Biological Processprimary shoot apical meristem specification
GO:0010089Biological Processxylem development
GO:0045597Biological Processpositive regulation of cell differentiation
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0008289Molecular Functionlipid binding
Sequence ? help Back to Top
Protein Sequence    Length: 829 aa     Download sequence    Send to blast
MDNGKYVRYT PEQVEALERL YHECPKPSSM RRQQLIRECP ILSNIEPKQI KVWFQNRSRC  60
REKQRKEASR LQTVNRKLTA MNKLLMEEND RLQKQVSQLV YENSYFRQQT QNATLATTDT  120
SCDSVVTSGQ HHLTPQQHPP PPPRDASPAG LLSIAEETLA EFLSKATGTA VEWVQLPGMK  180
PGPDSIGIVA ISHGCTGVAA RACGLVGLDP TRVAEILKDR PSWFRNCRSV DVLNVLSTGN  240
GGTIELLYMQ LYAPTTLAPA RDFWLLRYTS VLEDGSLVVC ERSLNNTQNG PSMPPVQNFV  300
RAEMLPSGYL IRPCEGGGSI LHIVDHMDLE PWSVPEVLRP LYESSTLLAQ KTTMAALRNL  360
RQISQEVSQP NSAGWGRRPA ALRALSQRLS KGFNEAVNGF TDEGWSVLES DGVDDVTLLV  420
NSSPGKMMSA NLYTNGVPSM STAVLCAKAS MLLQNVPPAI LLRFLREHRS EWADRSIDAY  480
SAAAIKAGPC NMLGPRAGSF GDQVILPLAH TIEHEEFMEV IKIENMGHYR EDMMMPAADI  540
FLLQLCSGVD ENAVGTXAEL VFAPIDASFS DDAPILPSGF RIIPLDSRMD TPSPNRTLDL  600
ASALEVGPAG SRASGDNAGH SGNTKSVMTI AFQFAFEIHL QENIAAMARQ YVRSIIASVQ  660
RVALALSPSH FGSHAGFRPP PGTPEAQTLA GWICQSYRCY LGGELLKTEG SESILKSLWH  720
HSDAILCCSL KAMPVFTFAN QAGLDMLETT LVALQDITLE KIFDDNGRKT LCSEFPQIMQ  780
QGFMCLQGGI CMSSMGRPIS YERAVAWKVL NEEETAHCIC FMFINWSFV
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Mdo.9440.0bud| fruit| stem
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in the procambial cells and the developing vascular system of embryos, roots and shoots. Expressed during the early stages of revascularization after cutting experiment. {ECO:0000269|PubMed:12447534, ECO:0000269|PubMed:8575317}.
Functional Description ? help Back to Top
Source Description
UniProtProbable transcription factor involved in the regulation of vascular development. May promote differentiation of precambial and cambial cells. {ECO:0000269|PubMed:11402194, ECO:0000269|PubMed:15598805}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By auxin. Repressed by miR165. {ECO:0000269|PubMed:17237362, ECO:0000269|PubMed:8575317}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankFJ1774270.0FJ177427.1 Malus x domestica putative HB8 HD-ZipIII mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001280750.10.0homeobox-leucine zipper protein ATHB-8
SwissprotQ391230.0ATHB8_ARATH; Homeobox-leucine zipper protein ATHB-8
TrEMBLA0A498J8K90.0A0A498J8K9_MALDO; Uncharacterized protein
STRINGXP_008378078.10.0(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19463387
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G32880.10.0homeobox gene 8
Publications ? help Back to Top
  1. Varkonyi-Gasic E,Gould N,Sandanayaka M,Sutherland P,MacDiarmid RM
    Characterisation of microRNAs from apple (Malus domestica 'Royal Gala') vascular tissue and phloem sap.
    BMC Plant Biol., 2010. 10: p. 159
    [PMID:20682080]
  2. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  3. Hategan L,Godza B,Kozma-Bognar L,Bishop GJ,Szekeres M
    Differential expression of the brassinosteroid receptor-encoding BRI1 gene in Arabidopsis.
    Planta, 2014. 239(5): p. 989-1001
    [PMID:24488524]
  4. Baima S, et al.
    Negative feedback regulation of auxin signaling by ATHB8/ACL5-BUD2 transcription module.
    Mol Plant, 2014. 7(6): p. 1006-1025
    [PMID:24777988]
  5. Kakehi J, et al.
    Mutations in ribosomal proteins, RPL4 and RACK1, suppress the phenotype of a thermospermine-deficient mutant of Arabidopsis thaliana.
    PLoS ONE, 2015. 10(1): p. e0117309
    [PMID:25625317]
  6. Jia X, et al.
    Functional plasticity of miR165/166 in plant development revealed by small tandem target mimic.
    Plant Sci., 2015. 233: p. 11-21
    [PMID:25711809]
  7. Liu S, et al.
    Expression of wild-type PtrIAA14.1, a poplar Aux/IAA gene causes morphological changes in Arabidopsis.
    Front Plant Sci, 2015. 6: p. 388
    [PMID:26082787]
  8. Yamaguchi YL, et al.
    Root-Knot and Cyst Nematodes Activate Procambium-Associated Genes in Arabidopsis Roots.
    Front Plant Sci, 2017. 8: p. 1195
    [PMID:28747918]
  9. Yamazaki K, et al.
    Suppression of DELLA signaling induces procambial cell formation in culture.
    Plant J., 2018. 94(1): p. 48-59
    [PMID:29383774]