PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Lus10042941
Organism
Linum usitatissimum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Linaceae; Linum
Family E2F/DP
Protein Properties Length: 400aa    MW: 44564.8 Da    PI: 7.0664
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Lus10042941genomeBGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP73.32.7e-232085171
      E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                 rk+ksL+ll+++fl+l+++  +++v l+++a +L    v  +rRRiYDi+NVLe+++++ +++kn+++wkg
  Lus10042941 20 RKQKSLGLLCTNFLNLYNRDGTEVVGLDDAAARL---GV--ERRRIYDIVNVLESVGVLCRRAKNQYTWKG 85
                 79********************************...**..****************************98 PP
2E2F_TDP73.52.2e-23166246171
      E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                  rkeksL+lltq+f+kl+ +s+++ ++l++ ak L+ +       ++k+RR+YDi+NVL++l+liek     ++k+++rw+g
  Lus10042941 166 RKEKSLGLLTQNFVKLFLCSKAELISLDNSAKLLLGDghslsVLRTKVRRLYDIANVLSSLKLIEKthtadSRKPAFRWIG 246
                  79***************************************97899**********************9999*******98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.7E-261686IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467853.63E-161983IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.0E-272085IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023196.4E-202185IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.108.4E-24161248IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013726.8E-28166246IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.2E-17167246IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467855.28E-12168247IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 400 aa     Download sequence    Send to blast
MNSGLTNETE SSSRHHSYSR KQKSLGLLCT NFLNLYNRDG TEVVGLDDAA ARLGVERRRI  60
YDIVNVLESV GVLCRRAKNQ YTWKGFGAMP ETLRGLKVQG MKENFSSSDT KNDNGAKGSS  120
GVGNEVEEDD DEEDVRDLES IVGIQIDAAA DSGNGQSAAA SKQDNRKEKS LGLLTQNFVK  180
LFLCSKAELI SLDNSAKLLL GDGHSLSVLR TKVRRLYDIA NVLSSLKLIE KTHTADSRKP  240
AFRWIGLNKS HESSTNAPLP DICESRKRGF GTDVTNISFK RNKLDSSAHE DNKIWKTKMH  300
SDQVKVDNEV IGVEGAILSQ ESVHESRTYQ FGPFGPAALL RDSGTVREAT EIRDWDTLSS  360
TFRPQYHNQA LRDLFVHYME AWQSWYTEVS EKKPIQQIS*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A1e-38192383228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapLus10042941
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankHQ8875513e-31HQ887551.1 Linum usitatissimum clone GMU2AYZ01AXKAY microsatellite sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_002511465.11e-162E2F transcription factor-like E2FE
SwissprotQ8LSZ41e-125E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLB9R8Z01e-161B9R8Z0_RICCO; E2F, putative
STRINGLus100429410.0(Linum usitatissimum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF36683366
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-128DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]