PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Lus10039455
Organism
Linum usitatissimum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Linaceae; Linum
Family E2F/DP
Protein Properties Length: 541aa    MW: 60537 Da    PI: 8.6979
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Lus10039455genomeBGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP52.86.3e-171131671271
      E2F_TDP  12 kflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                  +fl+l++++  + + l+++a +L    v  +rRRiYD++N+Le+++++++k+kn+++w+g
  Lus10039455 113 SFLNLYNTEGVDSIGLDDAAARL---GV--ERRRIYDVVNILESVGVVARKQKNRYSWRG 167
                  699****9999************...**..****************************98 PP
2E2F_TDP78.85e-25229308271
      E2F_TDP   2 keksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                  +eksL+lltq+f+kl+ +s+e+++tl+++a +L+ +      +++k+RR+YDi+NVL+++nliek     ++k+++rw+g
  Lus10039455 229 REKSLWLLTQNFVKLFLSSNEDMITLDTAAMALLGDavnstTMRTKVRRLYDIANVLSSMNLIEKihhpeSRKPAFRWMG 308
                  79*******************************************************************99*******98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:3.90.550.104.4E-55298IPR029044Nucleotide-diphospho-sugar transferases
SMARTSM013723.0E-16102167IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.14E-12104165IPR011991Winged helix-turn-helix DNA-binding domain
Gene3DG3DSA:1.10.10.108.5E-18113168IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023195.4E-14114167IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.107.2E-23224308IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.1E-29228308IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467853.63E-13230309IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023194.1E-20230308IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 541 aa     Download sequence    Send to blast
MRKENSVCMC LPSPMIFKSP LGNLSERAYG SRLFLFPSCT RKCECSQCVF ASRYLKEGRP  60
HGSAGGLSYF RDIIMEDNPS HIFLLNCDVC CSFPWSGVLG VNASSSFVDV DFSFLNLYNT  120
EGVDSIGLDD AAARLGVERR RIYDVVNILE SVGVVARKQK NRYSWRGFGA IPHALECLKQ  180
KSLVENFSAA SCPSSTQVPK ENEVGVSSNT LTEGQDNCSA SLKSADSKRE KSLWLLTQNF  240
VKLFLSSNED MITLDTAAMA LLGDAVNSTT MRTKVRRLYD IANVLSSMNL IEKIHHPESR  300
KPAFRWMGWR GNNGDVDTVK FQTNKRTFGA DITNFASKRN RVDWIDEKEN TPGHKRLQGM  360
HKDSHGSKLK QNMERKSKSF VFGPFSPTGM NKVSSAGNKS TRHIQDVETL ASTCYPQYCN  420
EAIGELLGHY VEAWKSWHVG VSGRERPERA RFLTSVVAGS LRGRPRCTPG RIVACMATLF  480
DERKRMLIQF GLGRLVDVNL KQIDMNVVSW IIEQYDYKID SIITLNAIKD ALDILESDND  540
*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A5e-3012430030228Transcription factor E2F8
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1138159RRRIYDVVNILESVGVVARKQK
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Does not bind retinoblastoma-related proteins. Acts as a growth regulator but is not associated with changes in the expression of cell cycle marker genes or in nuclear ploidy levels. Has no effect on cell proliferation, but may repress cell wall biosynthesis genes during cell elongation in differentiated cells. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15308755}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapLus10039455
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankEU8298481e-175EU829848.1 Linum usitatissimum clone LU0005G04 mRNA sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_012082422.11e-138E2F transcription factor-like E2FF
SwissprotQ8RWL02e-96E2FF_ARATH; E2F transcription factor-like E2FF
TrEMBLA0A067LLZ11e-137A0A067LLZ1_JATCU; Uncharacterized protein
STRINGLus100394550.0(Linum usitatissimum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF36683366
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G01330.11e-97DP-E2F-like protein 3
Publications ? help Back to Top
  1. Dohmann EM, et al.
    The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability.
    Development, 2008. 135(11): p. 2013-22
    [PMID:18434413]