PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Lus10029421

Organism

Linum usitatissimum

Taxonomic ID

4006

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Linaceae; Linum

Family

E2F/DP

Protein Properties

Length: 505aa MW: 55236.9 Da PI: 4.8149

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Lus10029421	genome	BGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	83.9	1.3e-26	150	215	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l++ +e+gi++ln++a++L +v ++RRiYDi+NVLe+ +liek+ kn+irwkg Lus10029421 150 RYDSSLGLLTKKFVNLIKVAEDGIIDLNKAAETL---EV--QKRRIYDITNVLEGTGLIEKTLKNRIRWKG 215 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	1.5E-27	148	216	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	1.0E-33	150	215	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	8.16E-17	150	213	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	4.7E-23	152	215	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF144074	2.46E-33	229	332	No hit	No description
CDD	cd14660	3.86E-50	229	332	No hit	No description
Pfam	PF16421	1.0E-34	231	330	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 505 aa Download sequence Send to blast
MSGGSPAASS SPQPPPPAVT SAPSSSGPIP PPMRRHLAFV SMKPPFVAPD DYHRFSTPPA 60 SSKVADRDAE AIVVRSPAFK RKLKLDDSGI DSTKWTTNTG HTDPSNSPFQ TPTKGGRTYK 120 PKSTKANKAL PQTPVSNPGS PSTLTPAGTR YDSSLGLLTK KFVNLIKVAE DGIIDLNKAA 180 ETLEVQKRRI YDITNVLEGT GLIEKTLKNR IRWKGVGGSD SGNVDGNASL LQAEIERLSL 240 EEQNLDNQIR EMSERLRNLS EDENNQKWLF VTEDDVKNLP CFQNQTLIAI KAPHGTTLEV 300 PDPDEAVDYA QRRYRIVLRS TMGPIDVYLV SQFEENFEEA IDTGPSTSVA HASSSSSSVN 360 PQVEMVSTQG TQNAVEPQLQ PPIQDDQHMF SDFNSTQEFV GGMMKIVPSD ADNETDYWLL 420 SDAADISITD MWKADGMLAD FYPSPSTPPR NVSPTQLTQS LGGHFNLALH SFLLLLQLML 480 IGWLNMNMLQ VDFEIADVQT PRPT*

Sequence ? help Back to Top

Protein Sequence Length: 505 aa Download sequence Send to blast

MSGGSPAASS SPQPPPPAVT SAPSSSGPIP PPMRRHLAFV SMKPPFVAPD DYHRFSTPPA  60
SSKVADRDAE AIVVRSPAFK RKLKLDDSGI DSTKWTTNTG HTDPSNSPFQ TPTKGGRTYK  120
PKSTKANKAL PQTPVSNPGS PSTLTPAGTR YDSSLGLLTK KFVNLIKVAE DGIIDLNKAA  180
ETLEVQKRRI YDITNVLEGT GLIEKTLKNR IRWKGVGGSD SGNVDGNASL LQAEIERLSL  240
EEQNLDNQIR EMSERLRNLS EDENNQKWLF VTEDDVKNLP CFQNQTLIAI KAPHGTTLEV  300
PDPDEAVDYA QRRYRIVLRS TMGPIDVYLV SQFEENFEEA IDTGPSTSVA HASSSSSSVN  360
PQVEMVSTQG TQNAVEPQLQ PPIQDDQHMF SDFNSTQEFV GGMMKIVPSD ADNETDYWLL  420
SDAADISITD MWKADGMLAD FYPSPSTPPR NVSPTQLTQS LGGHFNLALH SFLLLLQLML  480
IGWLNMNMLQ VDFEIADVQT PRPT*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	3e-24	138	217	2	75	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Lus10029421

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_017629499.1	0.0	PREDICTED: transcription factor E2FA-like
Swissprot	Q9FNY0	1e-158	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A2P5Y1W5	0.0	A0A2P5Y1W5_GOSBA; Uncharacterized protein
STRING	Lus10029421	0.0	(Linum usitatissimum)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF1947	34	90

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-151	E2F transcription factor 3

Link Out ? help Back to Top
Phytozome	Lus10029421

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]