PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Lus10013321

Organism

Linum usitatissimum

Taxonomic ID

4006

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Linaceae; Linum

Family

E2F/DP

Protein Properties

Length: 435aa MW: 47668.8 Da PI: 4.5626

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Lus10013321	genome	BGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	29.3	1.5e-09	155	201	1	45
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvse..dvknkrRR 45 r+++sL+llt+kf++l++++e+g+++ln++a++L +e + + RR Lus10013321 155 RYDSSLGLLTKKFINLIKQAEDGMLDLNKAADTLEAEveNLAIEERR 201 6899******************************5556644446666 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	6.7E-9	152	201	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	2.7E-4	155	210	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	2.2E-6	157	202	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF144074	4.71E-30	186	299	No hit	No description
CDD	cd14660	1.13E-45	186	299	No hit	No description
Pfam	PF16421	2.6E-29	188	297	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 435 aa Download sequence Send to blast
MEPNSQPPTG PTQPSPPPPT QLQIDAASSP SSTALKRQLF LSSVKPPFSP TGDYHRFGPD 60 PRRAADQEPE GIVVRTPPLK RKSDAPEHGV ESSGWNTSSA HTDVVNTPIQ TPVSVKGGKA 120 PKASRLSRSK KSASKNANAN ISSPGNNLTP TGPCRYDSSL GLLTKKFINL IKQAEDGMLD 180 LNKAADTLEA EVENLAIEER RLDERIRHFG ALKSYGRDMQ ERLRDLSEDE NNQKWLFVTE 240 DDIKNIPCFQ NETLIAIKAP HGTTLEVPDP EEAADYPQRR YKIVLRSTMG PIDVYLVSQF 300 EEKFEEIHGV EPPPPPSYPS SSSLNENHAT ASVAIENRGK DIENAEQDLN PPQDYFSGIM 360 KIVPTDVDSA ADYWLLSDAG VSITDMWGTD PGFEWDEFGT LHDDYAMENV SIPQPQTPPP 420 NPTEPPSAAN TTPQ*

Sequence ? help Back to Top

Protein Sequence Length: 435 aa Download sequence Send to blast

MEPNSQPPTG PTQPSPPPPT QLQIDAASSP SSTALKRQLF LSSVKPPFSP TGDYHRFGPD  60
PRRAADQEPE GIVVRTPPLK RKSDAPEHGV ESSGWNTSSA HTDVVNTPIQ TPVSVKGGKA  120
PKASRLSRSK KSASKNANAN ISSPGNNLTP TGPCRYDSSL GLLTKKFINL IKQAEDGMLD  180
LNKAADTLEA EVENLAIEER RLDERIRHFG ALKSYGRDMQ ERLRDLSEDE NNQKWLFVTE  240
DDIKNIPCFQ NETLIAIKAP HGTTLEVPDP EEAADYPQRR YKIVLRSTMG PIDVYLVSQF  300
EEKFEEIHGV EPPPPPSYPS SSSLNENHAT ASVAIENRGK DIENAEQDLN PPQDYFSGIM  360
KIVPTDVDSA ADYWLLSDAG VSITDMWGTD PGFEWDEFGT LHDDYAMENV SIPQPQTPPP  420
NPTEPPSAAN TTPQ*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5tuv_B	3e-16	188	299	13	111	Transcription factor E2F5
5tuv_E	3e-16	188	299	13	111	Transcription factor E2F5
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Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Lus10013321

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:18424613}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_021628243.1	0.0	transcription factor E2FB-like isoform X2
Swissprot	Q9FV71	1e-116	E2FB_ARATH; Transcription factor E2FB
TrEMBL	A0A067KKC2	0.0	A0A067KKC2_JATCU; Uncharacterized protein
TrEMBL	A0A2C9VY82	0.0	A0A2C9VY82_MANES; Uncharacterized protein
STRING	Lus10013321	0.0	(Linum usitatissimum)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF1947	34	90

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-103	E2F transcription factor 3

Link Out ? help Back to Top
Phytozome	Lus10013321

Publications ? help Back to Top
Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Wu M,Liu L,Hijazi H,Chan C A multi-layer inference approach to reconstruct condition-specific genes and their regulation. Bioinformatics, 2013. 29(12): p. 1541-52 [PMID:23610368] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325]