PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae; Lactucinae; Lactuca

Family

NAC

Protein Properties

Length: 391aa MW: 43966.4 Da PI: 5.1469

Description

NAC family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
gnl\|UG\|Lsa#S58684167	PU_unref	Unigene	View CDS
PUT-187a-Lactuca_sativa-5036	PU_ref	plantGDB	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	NAM	166.4	9.6e-52	26	153	1	128
NAM 1 lppGfrFhPtdeelvveyLkkkvegkkleleevikevdiykvePwdLp..kkvkaeekewyfFskrdkkyatgkrknratksgyWkatgkdkevlskkge 98 l+pGfrFhPtdeelv++yL++k+ gk++++ ++++e+d+yk+ePw+L + +k+++ ewyfFs+ d+ky +g+r nrat +gyWkatgkd++v + k+e Lsa017657 26 LAPGFRFHPTDEELVMYYLRRKACGKPFRF-QAVSEIDVYKSEPWELAdfSPLKTRDLEWYFFSPVDRKYGNGSRLNRATGKGYWKATGKDRSVRH-KSE 123 579***********************99.88**********84336777888**********************************.999 PP NAM 99 lvglkktLvfykgrapkgektdWvmheyrl 128 ++g+kktLvf++grap+g++t+Wvmheyrl Lsa017657 124 TIGMKKTLVFHSGRAPDGKRTNWVMHEYRL 153 **************************97 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF101941	4.84E-62	22	176	IPR003441	NAC domain
PROSITE profile	PS51005	57.712	26	176	IPR003441	NAC domain
Pfam	PF02365	3.4E-28	28	153	IPR003441	NAC domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 391 aa Download sequence Send to blast
MGHELIGVAP PSAAAATPAP PPPTSLAPGF RFHPTDEELV MYYLRRKACG KPFRFQAVSE 60 IDVYKSEPWE LADFSPLKTR DLEWYFFSPV DRKYGNGSRL NRATGKGYWK ATGKDRSVRH 120 KSETIGMKKT LVFHSGRAPD GKRTNWVMHE YRLLDQELLR AGVAQDSFVL CRIFQKSGLG 180 PPNGDRYAPF LEEEWTDDAA LMVPGGEADD DLANGDETRV HGNDIVHEDS AKKIVDEIEE 240 PQTIPFVCKR ERSEDCPLDC EPELETFSLF HNKRSKPCDP NSSNANGSED STTTSQDPRR 300 ALLEFPLLES IEAKQCHQPT TLPSFDASTL EKSVPPGYLK FINNLENEIL NVSMEKETLK 360 IEVMRAQAMI NILQSRIEVL SKENDGFRTS G

Sequence ? help Back to Top

Protein Sequence Length: 391 aa Download sequence Send to blast

MGHELIGVAP PSAAAATPAP PPPTSLAPGF RFHPTDEELV MYYLRRKACG KPFRFQAVSE  60
IDVYKSEPWE LADFSPLKTR DLEWYFFSPV DRKYGNGSRL NRATGKGYWK ATGKDRSVRH  120
KSETIGMKKT LVFHSGRAPD GKRTNWVMHE YRLLDQELLR AGVAQDSFVL CRIFQKSGLG  180
PPNGDRYAPF LEEEWTDDAA LMVPGGEADD DLANGDETRV HGNDIVHEDS AKKIVDEIEE  240
PQTIPFVCKR ERSEDCPLDC EPELETFSLF HNKRSKPCDP NSSNANGSED STTTSQDPRR  300
ALLEFPLLES IEAKQCHQPT TLPSFDASTL EKSVPPGYLK FINNLENEIL NVSMEKETLK  360
IEVMRAQAMI NILQSRIEVL SKENDGFRTS G

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1ut4_A	2e-52	20	176	11	165	NO APICAL MERISTEM PROTEIN
1ut4_B	2e-52	20	176	11	165	NO APICAL MERISTEM PROTEIN
1ut7_A	2e-52	20	176	11	165	NO APICAL MERISTEM PROTEIN
1ut7_B	2e-52	20	176	11	165	NO APICAL MERISTEM PROTEIN
3swm_A	2e-52	20	176	14	168	NAC domain-containing protein 19
3swm_B	2e-52	20	176	14	168	NAC domain-containing protein 19
3swm_C	2e-52	20	176	14	168	NAC domain-containing protein 19
3swm_D	2e-52	20	176	14	168	NAC domain-containing protein 19
3swp_A	2e-52	20	176	14	168	NAC domain-containing protein 19
3swp_B	2e-52	20	176	14	168	NAC domain-containing protein 19
3swp_C	2e-52	20	176	14	168	NAC domain-containing protein 19
3swp_D	2e-52	20	176	14	168	NAC domain-containing protein 19
4dul_A	2e-52	20	176	11	165	NAC domain-containing protein 19
4dul_B	2e-52	20	176	11	165	NAC domain-containing protein 19
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Functional Description ? help Back to Top
Source	Description
UniProt	Transcriptional repressor that binds to the motif 5'-(C/T)A(C/A)G-3' in the promoter of target genes (PubMed:25578968). Binds also to the 5'-CTTGNNNNNCAAG-3' consensus sequence in chromatin (PubMed:26617990). Can bind to the mitochondrial dysfunction motif (MDM) present in the upstream regions of mitochondrial dysfunction stimulon (MDS) genes involved in mitochondrial retrograde regulation (MRR) (PubMed:24045019). Together with NAC050 and JMJ14, regulates gene expression and flowering time by associating with the histone demethylase JMJ14, probably by the promotion of RNA-mediated gene silencing (PubMed:25578968, PubMed:26617990). Regulates siRNA-dependent post-transcriptional gene silencing (PTGS) through SGS3 expression modulation (PubMed:28207953). Required during pollen development (PubMed:19237690). {ECO:0000269\|PubMed:19237690, ECO:0000269\|PubMed:24045019, ECO:0000269\|PubMed:25578968, ECO:0000269\|PubMed:26617990, ECO:0000269\|PubMed:28207953}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Induced by type III effector proteins (TTEs) secreted by the pathogenic bacteria P.syringae pv. tomato DC3000 during basal defense. {ECO:0000269\|PubMed:16553893}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_023762705.1	0.0	NAC domain containing protein 52-like
Swissprot	Q9SQY0	1e-108	NAC52_ARATH; NAC domain containing protein 52
TrEMBL	A0A2J6LG73	0.0	A0A2J6LG73_LACSA; Uncharacterized protein
STRING	XP_009780872.1	0.0	(Nicotiana sylvestris)

Publications ? help Back to Top
Higgins JD,Ferdous M,Osman K,Franklin FC The RecQ helicase AtRECQ4A is required to remove inter-chromosomal telomeric connections that arise during meiotic recombination in Arabidopsis. Plant J., 2011. 65(3): p. 492-502 [PMID:21265901] Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Zhang S, et al. C-terminal domains of a histone demethylase interact with a pair of transcription factors and mediate specific chromatin association. Cell Discov, 2019. [PMID:26617990] Butel N,Le Masson I,Bouteiller N,Vaucheret H,Elmayan T sgs1: a neomorphic nac52 allele impairing post-transcriptional gene silencing through SGS3 downregulation. Plant J., 2017. 90(3): p. 505-519 [PMID:28207953] Elmayan T, et al. Arabidopsis mutants impaired in cosuppression. Plant Cell, 1998. 10(10): p. 1747-58 [PMID:9761800]