PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Lj1g3v0415900.1

Organism

Lotus japonicus

Taxonomic ID

34305

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Loteae; Lotus

Family

E2F/DP

Protein Properties

Length: 372aa MW: 42119.1 Da PI: 9.1998

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Lj1g3v0415900.1	genome	Kazusa	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	74	1.6e-23	15	80	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 rk+ksL+ll+++fl+l++k+ + l++++++L v +rRRiYDi+NVLe+++++++k+kn+++wkg Lj1g3v0415900.1 15 RKQKSLGLLCTNFLSLYNKEGIHLIGLDDACSRL---GV--ERRRIYDIVNVLESVGMLARKAKNQYTWKG 80 79***************999********.....****************************98 PP
2	E2F_TDP	75.7	4.7e-24	146	225	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvse....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 rkeksL+lltq+f+kl+ +s+ ++v+l+++ak L+ + +++k+RR+YDi+NVL+++nliek ++k+++rw g Lj1g3v0415900.1 146 RKEKSLTLLTQNFVKLFVCSNIQMVSLDDAAKLLLGNvdtaMMRTKVRRLYDIANVLSSINLIEKthmaeSRKPAFRWLG 225 79*******************************99999999********************9999999****87 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	3.5E-25	11	81	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	1.52E-15	14	78	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	1.5E-26	15	80	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	1.8E-19	16	80	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Gene3D	G3DSA:1.10.10.10	7.6E-24	142	227	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	2.0E-29	146	225	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	8.6E-20	147	225	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	2.54E-12	148	226	IPR011991	Winged helix-turn-helix DNA-binding domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 372 aa Download sequence Send to blast
MSSSTTSSRH HTYNRKQKSL GLLCTNFLSL YNKEGIHLIG LDDACSRLGV ERRRIYDIVN 60 VLESVGMLAR KAKNQYTWKG FAVIPEALRE LKDEGLKENL FDAANDSAKV SDDEYDEEAN 120 PATGSQNDKS NSDSATLVKS SQNENRKEKS LTLLTQNFVK LFVCSNIQMV SLDDAAKLLL 180 GNVDTAMMRT KVRRLYDIAN VLSSINLIEK THMAESRKPA FRWLGLKGKT RSESGNSAQD 240 PNTNESRKRL FGSDITNISF KRNKVDLFMN EGDFYKNSNM ENKHDNLNCQ GQSEKSNSKQ 300 DAKQTTGCYQ FGPFAPRKVG ASENDNVKQV HDWESLAKAH RPQYENLALR DLFSHYTEAW 360 KSWYSEVAGK RP

Sequence ? help Back to Top

Protein Sequence Length: 372 aa Download sequence Send to blast

MSSSTTSSRH HTYNRKQKSL GLLCTNFLSL YNKEGIHLIG LDDACSRLGV ERRRIYDIVN  60
VLESVGMLAR KAKNQYTWKG FAVIPEALRE LKDEGLKENL FDAANDSAKV SDDEYDEEAN  120
PATGSQNDKS NSDSATLVKS SQNENRKEKS LTLLTQNFVK LFVCSNIQMV SLDDAAKLLL  180
GNVDTAMMRT KVRRLYDIAN VLSSINLIEK THMAESRKPA FRWLGLKGKT RSESGNSAQD  240
PNTNESRKRL FGSDITNISF KRNKVDLFMN EGDFYKNSNM ENKHDNLNCQ GQSEKSNSKQ  300
DAKQTTGCYQ FGPFAPRKVG ASENDNVKQV HDWESLAKAH RPQYENLALR DLFSHYTEAW  360
KSWYSEVAGK RP

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
4yo2_A	9e-41	14	217	3	228	Transcription factor E2F8
Search in ModeBase

Expression -- Description ? help Back to Top
Source	Description
Uniprot	DEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Not detected during early S phase. Expressed at both the G1/S and S/G2 transitions, with a peak during G2. {ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:18787127}.
Uniprot	TISSUE SPECIFICITY: Expressed exclusively in mitotically dividing cells. Highly expressed in young leaves and mature flowers. Lower expression in young stalk and in young and mature flowers. {ECO:0000269\|PubMed:11867638, ECO:0000269\|PubMed:15649366}.

Functional Description ? help Back to Top
Source	Description
UniProt	Inhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11867638, ECO:0000269\|PubMed:15649366, ECO:0000269\|PubMed:18787127}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Lj1g3v0415900.1

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AP010585	0.0	AP010585.1 Lotus japonicus genomic DNA, chromosome 1, clone: LjB05K02, BM1960, complete sequence.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_016203170.1	0.0	E2F transcription factor-like E2FE
Refseq	XP_025655266.1	0.0	E2F transcription factor-like E2FE
Swissprot	Q8LSZ4	1e-121	E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBL	A0A444Z2R9	0.0	A0A444Z2R9_ARAHY; Uncharacterized protein
STRING	XP_007138128.1	1e-174	(Phaseolus vulgaris)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF3668	33	66

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G48160.2	1e-123	DP-E2F-like 1

Publications ? help Back to Top
Chandran D, et al. Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid. Cell Host Microbe, 2014. 15(4): p. 506-13 [PMID:24721578] Wang Z, et al. Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis. PLoS ONE, 2016. 11(8): p. e0160684 [PMID:27505251] Heyman J,Polyn S,Eekhout T,De Veylder L Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1. Plant Physiol., 2017. 175(1): p. 303-313 [PMID:28698355]