PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID LPERR06G00620.2
Organism
Leersia perrieri
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; BOP clade; Oryzoideae; Oryzeae; Oryzinae; Leersia
Family B3
Protein Properties Length: 423aa    MW: 45524.9 Da    PI: 4.7436
Description B3 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
LPERR06G00620.2genomeOGEView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1B340.26.2e-13307401198
                      EEEE-..-HHHHTT-EE--HHH.HTT---..--SEEEEEETTS-EEEEEE..EEETTEEEE-TTHHHHHHHHT--TT-EEEEEE-.SS.SEE.. CS
               B3   1 ffkvltpsdvlksgrlvlpkkfaeehggkkeesktltledesgrsWevkliyrkksgryvltkGWkeFvkangLkegDfvvFkld.gr.sefel 92 
                      f +v ++s+  ++ ++++p +f ++  +     +t ++ +  g+sW   ++ + k +++   +GW++F+ +n+L++gD +vF+l+    +  el
  LPERR06G00620.2 307 FTTVISRSHLRNKYQMWVPHRFQRRLPEA----RTGVVLHCGGKSWPASYCGDLKVKKIDV-AGWSNFAVDNRLRVGDACVFELIaAAdTHLEL 395
                      566677788888899*******9877533....36788999*********77666666554.5********************99544588888 PP

                      EEEEE- CS
               B3  93 vvkvfr 98 
                      +v+++r
  LPERR06G00620.2 396 KVQILR 401
                      888887 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:3.40.50.15806.6E-6916252IPR000845Nucleoside phosphorylase domain
PfamPF010483.1E-2219244IPR000845Nucleoside phosphorylase domain
SuperFamilySSF531671.13E-3620237IPR000845Nucleoside phosphorylase domain
SuperFamilySSF1019364.12E-15301401IPR015300DNA-binding pseudobarrel domain
Gene3DG3DSA:2.40.330.107.3E-16302401IPR015300DNA-binding pseudobarrel domain
CDDcd100172.63E-15305401No hitNo description
PfamPF023623.3E-11307401IPR003340B3 DNA binding domain
SMARTSM010191.5E-6307403IPR003340B3 DNA binding domain
PROSITE profilePS5086311.632307403IPR003340B3 DNA binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0000003Biological Processreproduction
GO:0001944Biological Processvasculature development
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009116Biological Processnucleoside metabolic process
GO:0019509Biological ProcessL-methionine biosynthetic process from methylthioadenosine
GO:0005634Cellular Componentnucleus
GO:0005829Cellular Componentcytosol
GO:0005886Cellular Componentplasma membrane
GO:0003677Molecular FunctionDNA binding
GO:0008930Molecular Functionmethylthioadenosine nucleosidase activity
Sequence ? help Back to Top
Protein Sequence    Length: 423 aa     Download sequence    Send to blast
MAPPSDDSPP LPAGAISNLL IVIAMQTEAL PLVNKFHLVE APSNESIFPK GAPWIRYHGN  60
YKGLHIDLVW PGKDPVLGVD CVGTVSAALV TYASIQSLKP DLIINAGTAG GFKAKGAGIG  120
DVFLASDVAF HDRRIPIPVF DMYGIGTRKT FATPNILKEL NLKVGKLSTG DSLDMSPHDE  180
SAIQNNDATV KDMEGAAVAY VADMFSTPAI FVKAVTDIVD GEKPTAEEFL QNLVAVTAAL  240
DKSVTEVMDS PSKQMMQADA SYTNLTGIIK PKVESCDDDD ELLPAPPASG SEDWEVTTPI  300
GTGNPFFTTV ISRSHLRNKY QMWVPHRFQR RLPEARTGVV LHCGGKSWPA SYCGDLKVKK  360
IDVAGWSNFA VDNRLRVGDA CVFELIAAAD THLELKVQIL RGDLPEEVTS KGATSDEPIL  420
IDD
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
2h8g_A1e-11116249262575'-Methylthioadenosine Nucleosidase
2h8g_B1e-11116249262575'-Methylthioadenosine Nucleosidase
2qsu_A1e-11116249262575'-methylthioadenosine nucleosidase
2qsu_B1e-11116249262575'-methylthioadenosine nucleosidase
2qtg_A1e-11116249262575'-methylthioadenosine nucleosidase
2qtg_B1e-11116249262575'-methylthioadenosine nucleosidase
2qtt_A1e-11116249262575'-methylthioadenosine nucleosidase
2qtt_B1e-11116249262575'-methylthioadenosine nucleosidase
3lgs_A1e-11116249262575'-methylthioadenosine nucleosidases
3lgs_B1e-11116249262575'-methylthioadenosine nucleosidases
3lgs_C1e-11116249262575'-methylthioadenosine nucleosidases
3lgs_D1e-11116249262575'-methylthioadenosine nucleosidases
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtEnzyme of the methionine cycle that catalyzes the irreversible cleavage of the glycosidic bond in 5'-methylthioadenosine (MTA) to adenine and 5'-methylthioribose. Contributes to the maintenance of AdoMet homeostasis and is required to sustain high rates of ethylene synthesis. Inactive towards S-adenosylhomocysteine (SAH/AdoHcy). {ECO:0000269|PubMed:17144895, ECO:0000269|PubMed:18342331, ECO:0000269|PubMed:20345605}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapLPERR06G00620.2
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAB1101650.0AB110165.1 Oryza sativa Japonica Group mRNA for hypothetical protein, complete cds, clone: 12FPG037.
GenBankAK0661720.0AK066172.1 Oryza sativa Japonica Group cDNA clone:J013056A05, full insert sequence.
GenBankAK1047970.0AK104797.1 Oryza sativa Japonica Group cDNA clone:001-039-H06, full insert sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006655705.11e-166PREDICTED: 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 2-like
SwissprotQ9T0I81e-110MTN1_ARATH; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 1
TrEMBLA0A0D9WKZ40.0A0A0D9WKZ4_9ORYZ; Uncharacterized protein
STRINGLPERR06G00620.10.0(Leersia perrieri)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G49480.15e-09related to vernalization1 1
Publications ? help Back to Top
  1. Park EY, et al.
    Crystal structure of 5'-methylthioadenosine nucleosidase from Arabidopsis thaliana at 1.5-A resolution.
    Proteins, 2006. 65(2): p. 519-23
    [PMID:16909418]
  2. Bürstenbinder K,Rzewuski G,Wirtz M,Hell R,Sauter M
    The role of methionine recycling for ethylene synthesis in Arabidopsis.
    Plant J., 2007. 49(2): p. 238-49
    [PMID:17144895]
  3. Marmagne A, et al.
    A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome.
    Mol. Cell Proteomics, 2007. 6(11): p. 1980-96
    [PMID:17644812]
  4. Siu KK, et al.
    Molecular determinants of substrate specificity in plant 5'-methylthioadenosine nucleosidases.
    J. Mol. Biol., 2008. 378(1): p. 112-28
    [PMID:18342331]
  5. Park EY, et al.
    Biochemical and structural characterization of 5'-methylthioadenosine nucleosidases from Arabidopsis thaliana.
    Biochem. Biophys. Res. Commun., 2009. 381(4): p. 619-24
    [PMID:19249293]
  6. Bürstenbinder K, et al.
    Inhibition of 5'-methylthioadenosine metabolism in the Yang cycle alters polyamine levels, and impairs seedling growth and reproduction in Arabidopsis.
    Plant J., 2010. 62(6): p. 977-88
    [PMID:20345605]
  7. Siu KK, et al.
    Mechanism of substrate specificity in 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases.
    J. Struct. Biol., 2011. 173(1): p. 86-98
    [PMID:20554051]
  8. Pommerrenig B, et al.
    Phloem-specific expression of Yang cycle genes and identification of novel Yang cycle enzymes in Plantago and Arabidopsis.
    Plant Cell, 2011. 23(5): p. 1904-19
    [PMID:21540433]
  9. Waduwara-Jayabahu I, et al.
    Recycling of methylthioadenosine is essential for normal vascular development and reproduction in Arabidopsis.
    Plant Physiol., 2012. 158(4): p. 1728-44
    [PMID:22345506]
  10. Schenck CA, et al.
    A proteomics approach identifies novel proteins involved in gravitropic signal transduction.
    Am. J. Bot., 2013. 100(1): p. 194-202
    [PMID:23281391]
  11. Ok SH, et al.
    Calcineurin B-like 3 calcium sensor associates with and inhibits 5'-methylthioadenosine nucleosidase 2 in Arabidopsis.
    Plant Sci., 2015. 238: p. 228-40
    [PMID:26259190]
  12. Washington EJ, et al.
    Pseudomonas syringae type III effector HopAF1 suppresses plant immunity by targeting methionine recycling to block ethylene induction.
    Proc. Natl. Acad. Sci. U.S.A., 2016. 113(25): p. E3577-86
    [PMID:27274076]