PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; BOP clade; Oryzoideae; Oryzeae; Oryzinae; Leersia

Family

E2F/DP

Protein Properties

Length: 479aa MW: 51820 Da PI: 4.8131

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
LPERR04G00320.1	genome	OGE	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	82.7	3.1e-26	198	263	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++lle +e+g+++ln++a++L +v ++RRiYDi+NVLe+++liek+ kn irwkg LPERR04G00320.1 198 RYDSSLGLLTKKFINLLEGAEDGTLDLNKAAETL---EV--QKRRIYDITNVLEGVDLIEKTLKNMIRWKG 263 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	3.1E-28	194	264	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	7.7E-34	198	263	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	1.63E-16	198	261	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	1.2E-23	200	263	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	2.30E-35	274	387	No hit	No description
SuperFamily	SSF144074	1.1E-24	275	386	No hit	No description
Pfam	PF16421	2.4E-24	279	384	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0000902	Biological Process	cell morphogenesis
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0042023	Biological Process	DNA endoreduplication
GO:0051782	Biological Process	negative regulation of cell division
GO:0005667	Cellular Component	transcription factor complex
GO:0005730	Cellular Component	nucleolus
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0044212	Molecular Function	transcription regulatory region DNA binding
GO:0046982	Molecular Function	protein heterodimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 479 aa Download sequence Send to blast
MDGSSSIPLP HPSPPPRPAA PPQVFLRRAV LPPPPPPGAH VHYFRAASPI PIFRAAAGPR 60 GAASSRPPRP PPPPQAATAP PPAPAPAPAR VAPPQQPPVS VAPPPTPSTA STSVSEEVAA 120 TPGTGNPMAN AAENEEKNES VHPEVGKAET IQGPDKESAT GTGKGIKRPR KQKGFGKGSL 180 QSNEGDAGPS LFSSNNCRYD SSLGLLTKKF INLLEGAEDG TLDLNKAAET LEVQKRRIYD 240 ITNVLEGVDL IEKTLKNMIR WKGFDMSKPK ERERQISALK EEIESLYDEE SRLDGEIMEA 300 QEKLNALLVN ENTKKLLYVS KEDINAIPRF QRSTLIAINA PRGTYIEVPD PNADMDIYED 360 LDNQEKHYQI ILRSAMGPVD CFLISDHQES FNPDQQIASN LDAVVTSGSS QALQQMDYVP 420 SQAPESGEST DVREHTSEPS KRDDPVPGIL KIVPSHNDIT ADYWLCSDAD VSMTDTWAT

Sequence ? help Back to Top

Protein Sequence Length: 479 aa Download sequence Send to blast

MDGSSSIPLP HPSPPPRPAA PPQVFLRRAV LPPPPPPGAH VHYFRAASPI PIFRAAAGPR  60
GAASSRPPRP PPPPQAATAP PPAPAPAPAR VAPPQQPPVS VAPPPTPSTA STSVSEEVAA  120
TPGTGNPMAN AAENEEKNES VHPEVGKAET IQGPDKESAT GTGKGIKRPR KQKGFGKGSL  180
QSNEGDAGPS LFSSNNCRYD SSLGLLTKKF INLLEGAEDG TLDLNKAAET LEVQKRRIYD  240
ITNVLEGVDL IEKTLKNMIR WKGFDMSKPK ERERQISALK EEIESLYDEE SRLDGEIMEA  300
QEKLNALLVN ENTKKLLYVS KEDINAIPRF QRSTLIAINA PRGTYIEVPD PNADMDIYED  360
LDNQEKHYQI ILRSAMGPVD CFLISDHQES FNPDQQIASN LDAVVTSGSS QALQQMDYVP  420
SQAPESGEST DVREHTSEPS KRDDPVPGIL KIVPSHNDIT ADYWLCSDAD VSMTDTWAT

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	5e-22	198	263	7	73	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	LPERR04G00320.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:18424613}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_015633977.1	0.0	transcription factor E2FC
Swissprot	Q9FV71	1e-84	E2FB_ARATH; Transcription factor E2FB
TrEMBL	A0A0D9W1U3	0.0	A0A0D9W1U3_9ORYZ; Uncharacterized protein
STRING	LPERR04G00320.1	0.0	(Leersia perrieri)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Monocots	OGMP625	37	148

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G22220.3	6e-86	E2F transcription factor 1

Publications ? help Back to Top
Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Wu M,Liu L,Hijazi H,Chan C A multi-layer inference approach to reconstruct condition-specific genes and their regulation. Bioinformatics, 2013. 29(12): p. 1541-52 [PMID:23610368] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325]