PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; Saxifragales; Crassulaceae; Kalanchoe

Family

E2F/DP

Protein Properties

Length: 308aa MW: 34344.9 Da PI: 4.1259

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Kalax.1099s0001.1.p	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	58	1.6e-18	2	43	25	71
E2F_TDP 25 vtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 ++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+irwkg Kalax.1099s0001.1.p 2 LDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 43 79******...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	5.1E-19	1	45	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	1.3E-8	1	43	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	2.4E-16	2	43	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	3.67E-12	2	44	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF144074	1.96E-33	56	160	No hit	No description
CDD	cd14660	1.46E-48	56	160	No hit	No description
Pfam	PF16421	8.7E-34	59	158	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 308 aa Download sequence Send to blast
MLDLNKAAET LEVQKRRIYD ITNVLEGIGL IEKKLKNRIR WKGLDVSQPD GVETDVSRLQ 60 IDVENLNLEE QNLDDQIRGM QERLRDLSED ENNQKWLFVT EEDIKSLPCF QNETLIAIKA 120 PHGTTLEVPD PDEAANYPQR RYRIVLRSTM GPIDVYLVSQ FEEKFEDMNG AEQSVNCPVA 180 STSRPVENSG AGVANTQSTE NDITGQAQDA HRVPSDILMN DNGSDDFVGG IMKIVPDVNA 240 DTDYWFLSDA ELSVTELWHP ESGIGNHLDD MPHHTDYEIG DTSIPQPQTP PSAVTDIPSS 300 SVNSTPR*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5tuv_B	1e-17	59	160	13	111	Transcription factor E2F5
5tuv_E	1e-17	59	160	13	111	Transcription factor E2F5
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_008243467.1	1e-139	PREDICTED: transcription factor E2FA
Swissprot	Q9FNY0	1e-105	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A2I4E128	1e-137	A0A2I4E128_JUGRE; transcription factor E2FA-like
STRING	XP_008243467.1	1e-139	(Prunus mume)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-109	E2F transcription factor 3

Link Out ? help Back to Top
Phytozome	Kalax.1099s0001.1.p

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]