PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; Saxifragales; Crassulaceae; Kalanchoe

Family

C2H2

Protein Properties

Length: 608aa MW: 67684.1 Da PI: 4.2334

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Kalax.0830s0002.1.p	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	12.3	0.00051	111	129	2	20
EETTTTEEESSHHHHHHHH CS zf-C2H2 2 kCpdCgksFsrksnLkrHi 20 kC +C+ sF+++ +L+ H+ Kalax.0830s0002.1.p 111 KCWICNLSFPSSQELQAHL 129 7*****************7 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF57667	6.53E-32	40	169	No hit	No description
Pfam	PF12756	4.4E-8	57	130	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS51678	74.544	249	564	IPR025799	Protein arginine N-methyltransferase
Gene3D	G3DSA:3.40.50.150	1.2E-32	250	408	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase
SuperFamily	SSF53335	8.66E-59	256	551	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase
Pfam	PF13649	8.7E-8	292	405	No hit	No description
CDD	cd02440	5.95E-9	293	408	No hit	No description
Gene3D	G3DSA:2.70.160.11	2.0E-43	412	590	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006479	Biological Process	protein methylation
GO:0005829	Cellular Component	cytosol
GO:0008168	Molecular Function	methyltransferase activity

Sequence ? help Back to Top
Protein Sequence Length: 608 aa Download sequence Send to blast
MLVPAEMEHV PNLAAPEEED NNEIDDDVEE QGWDDWRAGS DGGAEDEEGD PEPDMLCLFC 60 DSVFTSRDDI FGHCAGAHRF DFSELRKKLG LDFYACFKLL NYIRIQVAER KCWICNLSFP 120 SSQELQAHLH PTVDFNRSNL PWEDDKYLSP FIQDDPLLYI FGEDEDDVDY PNEEDREELI 180 KEIELLKVDD IINELSIRND NLKTCTVNGL TDRPSTSDGS FKPYNETAED RDSKIPLSNA 240 VTVQIKNANR SYFGGYSSFV IHREMISDKV RTDAYRDAIL GNPCLFNGAI LMDVGCGTGI 300 LSLFAVQAGA SRVIAVEASE KMASMATQIA KDNALLWEKS PGLNSKGNGG IQVVQGMIEE 360 INDFDGILPN SVDVLISEWM GYCLLYETML NSVLFARDRW LKPGGAVLPD TATMFVAGFG 420 KGATSIPFWD NVYGFNMSCI GTEVVEHASK NPIVDVVDSE DIVTNSVVLK AFDLATVTPE 480 ELDFTTSVAL EPKSNDVTWC YGLVLWFDTN FTSRFCKEKQ TVLSTSPFTQ KTHWSQTILT 540 FREPVALFSG EPSAKLMSDG VTPWAKMLAR ISIARAAQHR SIDISLEVTA TSLDGRKHRL 600 PAQLFTL*

Sequence ? help Back to Top

Protein Sequence Length: 608 aa Download sequence Send to blast

MLVPAEMEHV PNLAAPEEED NNEIDDDVEE QGWDDWRAGS DGGAEDEEGD PEPDMLCLFC  60
DSVFTSRDDI FGHCAGAHRF DFSELRKKLG LDFYACFKLL NYIRIQVAER KCWICNLSFP  120
SSQELQAHLH PTVDFNRSNL PWEDDKYLSP FIQDDPLLYI FGEDEDDVDY PNEEDREELI  180
KEIELLKVDD IINELSIRND NLKTCTVNGL TDRPSTSDGS FKPYNETAED RDSKIPLSNA  240
VTVQIKNANR SYFGGYSSFV IHREMISDKV RTDAYRDAIL GNPCLFNGAI LMDVGCGTGI  300
LSLFAVQAGA SRVIAVEASE KMASMATQIA KDNALLWEKS PGLNSKGNGG IQVVQGMIEE  360
INDFDGILPN SVDVLISEWM GYCLLYETML NSVLFARDRW LKPGGAVLPD TATMFVAGFG  420
KGATSIPFWD NVYGFNMSCI GTEVVEHASK NPIVDVVDSE DIVTNSVVLK AFDLATVTPE  480
ELDFTTSVAL EPKSNDVTWC YGLVLWFDTN FTSRFCKEKQ TVLSTSPFTQ KTHWSQTILT  540
FREPVALFSG EPSAKLMSDG VTPWAKMLAR ISIARAAQHR SIDISLEVTA TSLDGRKHRL  600
PAQLFTL*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
6nt2_A	5e-70	252	551	53	329	Protein arginine N-methyltransferase 1
6nt2_B	5e-70	252	551	53	329	Protein arginine N-methyltransferase 1
6nt2_C	5e-70	252	551	53	329	Protein arginine N-methyltransferase 1
6nt2_D	5e-70	252	551	53	329	Protein arginine N-methyltransferase 1
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Functional Description ? help Back to Top
Source	Description
UniProt	Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins. {ECO:0000250}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_010659086.1	0.0	PREDICTED: probable protein arginine N-methyltransferase 3
Swissprot	Q0WVD6	0.0	ANM3_ARATH; Probable protein arginine N-methyltransferase 3
TrEMBL	F6HVC8	0.0	F6HVC8_VITVI; Uncharacterized protein
STRING	VIT_13s0084g00650.t01	0.0	(Vitis vinifera)

Link Out ? help Back to Top
Phytozome	Kalax.0830s0002.1.p

Publications ? help Back to Top
Krause CD, et al. Protein arginine methyltransferases: evolution and assessment of their pharmacological and therapeutic potential. Pharmacol. Ther., 2007. 113(1): p. 50-87 [PMID:17005254] Hang R, et al. Arabidopsis protein arginine methyltransferase 3 is required for ribosome biogenesis by affecting precursor ribosomal RNA processing. Proc. Natl. Acad. Sci. U.S.A., 2014. 111(45): p. 16190-5 [PMID:25352672]