PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; Saxifragales; Crassulaceae; Kalanchoe

Family

E2F/DP

Protein Properties

Length: 480aa MW: 52949.1 Da PI: 4.9378

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Kalax.0384s0035.1.p	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	86.1	2.6e-27	142	207	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l++++e+gi++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+irwkg Kalax.0384s0035.1.p 142 RYDSSLGLLTKKFINLIKHAEDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 207 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	3.3E-29	139	209	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	2.0E-34	142	207	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	5.17E-17	142	205	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	2.4E-24	144	207	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	1.22E-46	222	324	No hit	No description
SuperFamily	SSF144074	3.4E-33	222	324	No hit	No description
Pfam	PF16421	1.9E-33	223	322	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 480 aa Download sequence Send to blast
MSGPRAPNRS APAPPQPQIS QPTKRHLPFT SIKPPFPAPA AADYHRFDAR HLGAQEADAI 60 VVRSPQLKRK SIAEDNEVAF SNWTNSTVYT EADKSPLKTP MSAKGGRVYN KSKGSKGNKA 120 AAQTPMLTAG SPSALTPAGN CRYDSSLGLL TKKFINLIKH AEDGILDLNK AAETLEVQKR 180 RIYDITNVLE GIGLIEKKLK NRIRWKGLDV SQPGGVETDV FSLQTDVENL TLEEQKLDDE 240 IREMQERLRY LSEDENNQKW LFVTEDDIKS LPCFQNETLI AIKAPHGTTL EVPDPDEAAD 300 YPQRRYRIVL RSTMGPIDVY LVSQFEEKFE DMNGAEQSVN CPVASTSRSV ENSGTHATNT 360 ESMGNDITGQ AQDARRLPSD HQMNDNGSDD FVSGIMKIVP DVNTDTDYWF LSDAELSVTE 420 LWHSESGIGN HLEDMHHANY EIGDTSIPQP QTPPSGVTDI PPPSVNSTPR LVCSPKTIE*

Sequence ? help Back to Top

Protein Sequence Length: 480 aa Download sequence Send to blast

MSGPRAPNRS APAPPQPQIS QPTKRHLPFT SIKPPFPAPA AADYHRFDAR HLGAQEADAI  60
VVRSPQLKRK SIAEDNEVAF SNWTNSTVYT EADKSPLKTP MSAKGGRVYN KSKGSKGNKA  120
AAQTPMLTAG SPSALTPAGN CRYDSSLGLL TKKFINLIKH AEDGILDLNK AAETLEVQKR  180
RIYDITNVLE GIGLIEKKLK NRIRWKGLDV SQPGGVETDV FSLQTDVENL TLEEQKLDDE  240
IREMQERLRY LSEDENNQKW LFVTEDDIKS LPCFQNETLI AIKAPHGTTL EVPDPDEAAD  300
YPQRRYRIVL RSTMGPIDVY LVSQFEEKFE DMNGAEQSVN CPVASTSRSV ENSGTHATNT  360
ESMGNDITGQ AQDARRLPSD HQMNDNGSDD FVSGIMKIVP DVNTDTDYWF LSDAELSVTE  420
LWHSESGIGN HLEDMHHANY EIGDTSIPQP QTPPSGVTDI PPPSVNSTPR LVCSPKTIE*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	4e-24	137	208	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_010654143.1	0.0	PREDICTED: transcription factor E2FA isoform X2
Swissprot	Q9FNY0	1e-153	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A438JAG6	0.0	A0A438JAG6_VITVI; Transcription factor E2FA
TrEMBL	D7TH52	0.0	D7TH52_VITVI; Uncharacterized protein
STRING	VIT_08s0007g02510.t01	0.0	(Vitis vinifera)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-150	E2F transcription factor 3

Link Out ? help Back to Top
Phytozome	Kalax.0384s0035.1.p

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]