PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; Saxifragales; Crassulaceae; Kalanchoe

Family

C2H2

Protein Properties

Length: 1433aa MW: 158794 Da PI: 6.9469

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Kalax.0045s0142.1.p	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	11.1	0.0012	1397	1423	1	23
EEET..TTTEEESSHHHHHHHHHH..T CS zf-C2H2 1 ykCp..dCgksFsrksnLkrHirt..H 23 ykC+ Cg sF+ s++ rH r+ H Kalax.0045s0142.1.p 1397 YKCKaeGCGVSFRFISDFSRHRRKtgH 1423 99*********************9777 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SMART	SM00545	3.3E-14	15	56	IPR003349	JmjN domain
PROSITE profile	PS51183	13.55	16	57	IPR003349	JmjN domain
Pfam	PF02375	2.8E-14	17	50	IPR003349	JmjN domain
SuperFamily	SSF51197	1.81E-26	258	446	No hit	No description
SMART	SM00558	1.4E-43	281	450	IPR003347	JmjC domain
PROSITE profile	PS51184	33.823	281	450	IPR003347	JmjC domain
Pfam	PF02373	2.2E-35	314	433	IPR003347	JmjC domain
PROSITE pattern	PS00028	0	1316	1340	IPR007087	Zinc finger, C2H2
SuperFamily	SSF57667	6.82E-7	1325	1374	No hit	No description
PROSITE profile	PS50157	12.778	1337	1366	IPR007087	Zinc finger, C2H2
SMART	SM00355	0.32	1337	1361	IPR015880	Zinc finger, C2H2-like
Gene3D	G3DSA:3.30.160.60	2.1E-5	1338	1360	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE pattern	PS00028	0	1339	1361	IPR007087	Zinc finger, C2H2
Gene3D	G3DSA:3.30.160.60	1.3E-5	1361	1374	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profile	PS50157	12.196	1367	1396	IPR007087	Zinc finger, C2H2
SMART	SM00355	0.002	1367	1391	IPR015880	Zinc finger, C2H2-like
PROSITE pattern	PS00028	0	1369	1391	IPR007087	Zinc finger, C2H2
Gene3D	G3DSA:3.30.160.60	4.9E-7	1375	1392	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamily	SSF57667	1.28E-10	1377	1423	No hit	No description
Gene3D	G3DSA:3.30.160.60	2.0E-10	1393	1420	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profile	PS50157	10.637	1397	1428	IPR007087	Zinc finger, C2H2
SMART	SM00355	1.5	1397	1423	IPR015880	Zinc finger, C2H2-like
PROSITE pattern	PS00028	0	1399	1423	IPR007087	Zinc finger, C2H2

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0009741	Biological Process	response to brassinosteroid
GO:0009826	Biological Process	unidimensional cell growth
GO:0033169	Biological Process	histone H3-K9 demethylation
GO:0048577	Biological Process	negative regulation of short-day photoperiodism, flowering
GO:0048579	Biological Process	negative regulation of long-day photoperiodism, flowering
GO:0005634	Cellular Component	nucleus
GO:0003676	Molecular Function	nucleic acid binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 1433 aa Download sequence Send to blast
MRDVEVPHWL IKLPLAPEFR PTDTEFADPI AYISKIENEA SAFGICKIIP PLPRPSKKYV 60 FSNLNRSLLK SPELGSDATA VKSCSGVNEG EVRAVFTTRQ QELGHTEKKD KAAIHMGQGA 120 VNKQVWQSGE LYTLDQFESK AKAFYRSTLG MVKDISPLAI EALFWKADSE NHLYVEYAND 180 VPGSGFGEPS GNGSFQHFHK RRRKRVFRRT TESSRKKYEV CGANESHADI QENNLSSETS 240 NVIVKVNTHV DAPVSSDKTA SVYHQDKSDS TTDIEGTAGW KLSNCPWNLQ VIARSPGSLT 300 RFMPDDIPGV TSPMVYIGML FSWFAWHVED HELHSLNFLH TGSSKTWYSV PGDYAFAFEE 360 VIRTRAYGEN VDRLAALMML GEKTTLLSPE VVVASGIPCC RLVQNPGEFV VTFPRAYHVG 420 FSHGFNCGEA ANFGTPQWLK VAKEAAVRRA AMNFLPMLSH QQLLYLLAMS FLTRVPRALL 480 VGARSSRLRD RMKEERELSV KKAFIEDILN EDKLLSVLRG AKSTYRAVLW DPESLPSLSK 540 EPSLLSKMEN TAANASDSSN SCVFQSNHNL LDEMRFYTET MKDDYVDDDG FLSDFQVDYG 600 AVACVACGIL GFPFMTVVQP SEAASLHLRP LLENKSVAQD GSCLDLDVSI DHSISVLSKP 660 VVSSNMKVNK EQNASHRFFR PRVFCLEHAV QVIELLESKG GAEVLVICHS DFQKIKSHAA 720 AVAGELGSKY NYDMVPLDCA SLEDLNLIDL AVDEDREESD EDWSSVLGIN LRCCIKMRKN 780 SSSKHVDLAL KLFGLPSNIT LGSSLSRLKW QHTRSRSKTP ILHDSKQLSK LVSNGIKKEK 840 KIIQYKRRKS KPKSFGSAPV RNTSLDCEDN SASVSSDTDI AGISMSELDN SVDINKSPAS 900 MTVLNQVEGS LVTPCPSLEI MHSNIVDQLE ESGSVRCVCV STSVDVVGAD NGVHDTRYKG 960 ETSLNCAVEH SSCADSPVRM EGMSASENNG QIRSTDTTNI KDTIEHEIAI HVDGKNVLTS 1020 MEPDLVAGGI PSAANPMRGK THMDNFPEWE VKDEVCAVIP YNERSNEGSP SLLSQSLTQM 1080 SAFEGSSTLL PLASCSTEEY VLVKDTRNSK VADTPGTEEN LCSGSLDKLR DNSINAEPAY 1140 LVSIETSVGD DSSYEVVQIR TLKGVDDKED PNNRRLTDFN QVSLMSAGDE SAAAKYMGAS 1200 KDLYDVDPVC SPAKTGETEN NRVKPKPSNR NARKRNRELE KLRDNKNEVA DFIRSPCEGL 1260 RPRSKIASSS HNIDVRHSYT EEPAIAKKKL KQIPADTSTS TPDRTGKQEL KGSHRCDLEC 1320 CILSFKTKAK LLLHQQNQCH IQGCGKKFSC HRYLIVHQRV HVDDRPLKCS WKGCNMSFKW 1380 AWARTEHLRV HTGERPYKCK AEGCGVSFRF ISDFSRHRRK TGHGGDTHSP LG*

Sequence ? help Back to Top

Protein Sequence Length: 1433 aa Download sequence Send to blast

MRDVEVPHWL IKLPLAPEFR PTDTEFADPI AYISKIENEA SAFGICKIIP PLPRPSKKYV  60
FSNLNRSLLK SPELGSDATA VKSCSGVNEG EVRAVFTTRQ QELGHTEKKD KAAIHMGQGA  120
VNKQVWQSGE LYTLDQFESK AKAFYRSTLG MVKDISPLAI EALFWKADSE NHLYVEYAND  180
VPGSGFGEPS GNGSFQHFHK RRRKRVFRRT TESSRKKYEV CGANESHADI QENNLSSETS  240
NVIVKVNTHV DAPVSSDKTA SVYHQDKSDS TTDIEGTAGW KLSNCPWNLQ VIARSPGSLT  300
RFMPDDIPGV TSPMVYIGML FSWFAWHVED HELHSLNFLH TGSSKTWYSV PGDYAFAFEE  360
VIRTRAYGEN VDRLAALMML GEKTTLLSPE VVVASGIPCC RLVQNPGEFV VTFPRAYHVG  420
FSHGFNCGEA ANFGTPQWLK VAKEAAVRRA AMNFLPMLSH QQLLYLLAMS FLTRVPRALL  480
VGARSSRLRD RMKEERELSV KKAFIEDILN EDKLLSVLRG AKSTYRAVLW DPESLPSLSK  540
EPSLLSKMEN TAANASDSSN SCVFQSNHNL LDEMRFYTET MKDDYVDDDG FLSDFQVDYG  600
AVACVACGIL GFPFMTVVQP SEAASLHLRP LLENKSVAQD GSCLDLDVSI DHSISVLSKP  660
VVSSNMKVNK EQNASHRFFR PRVFCLEHAV QVIELLESKG GAEVLVICHS DFQKIKSHAA  720
AVAGELGSKY NYDMVPLDCA SLEDLNLIDL AVDEDREESD EDWSSVLGIN LRCCIKMRKN  780
SSSKHVDLAL KLFGLPSNIT LGSSLSRLKW QHTRSRSKTP ILHDSKQLSK LVSNGIKKEK  840
KIIQYKRRKS KPKSFGSAPV RNTSLDCEDN SASVSSDTDI AGISMSELDN SVDINKSPAS  900
MTVLNQVEGS LVTPCPSLEI MHSNIVDQLE ESGSVRCVCV STSVDVVGAD NGVHDTRYKG  960
ETSLNCAVEH SSCADSPVRM EGMSASENNG QIRSTDTTNI KDTIEHEIAI HVDGKNVLTS  1020
MEPDLVAGGI PSAANPMRGK THMDNFPEWE VKDEVCAVIP YNERSNEGSP SLLSQSLTQM  1080
SAFEGSSTLL PLASCSTEEY VLVKDTRNSK VADTPGTEEN LCSGSLDKLR DNSINAEPAY  1140
LVSIETSVGD DSSYEVVQIR TLKGVDDKED PNNRRLTDFN QVSLMSAGDE SAAAKYMGAS  1200
KDLYDVDPVC SPAKTGETEN NRVKPKPSNR NARKRNRELE KLRDNKNEVA DFIRSPCEGL  1260
RPRSKIASSS HNIDVRHSYT EEPAIAKKKL KQIPADTSTS TPDRTGKQEL KGSHRCDLEC  1320
CILSFKTKAK LLLHQQNQCH IQGCGKKFSC HRYLIVHQRV HVDDRPLKCS WKGCNMSFKW  1380
AWARTEHLRV HTGERPYKCK AEGCGVSFRF ISDFSRHRRK TGHGGDTHSP LG*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
6ip0_A	2e-55	273	469	146	351	Transcription factor jumonji (Jmj) family protein
6ip4_A	2e-55	273	469	146	351	Arabidopsis JMJ13
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Acts probably as a histone 'Lys-4' (H3K4me) demethylase. Involved in transcriptional gene regulation. Acts as a repressor of the photoperiodic flowering pathway and of FT. Binds around the transcription start site of the FT locus. {ECO:0000269\|PubMed:15377760, ECO:0000269\|PubMed:18467490, ECO:0000269\|PubMed:19946624}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_008233302.1	0.0	PREDICTED: probable lysine-specific demethylase ELF6
Swissprot	Q6BDA0	0.0	ELF6_ARATH; Probable lysine-specific demethylase ELF6
TrEMBL	A0A2N9ER00	0.0	A0A2N9ER00_FAGSY; Uncharacterized protein
STRING	XP_008233302.1	0.0	(Prunus mume)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G04240.1	0.0	C2H2 family protein

Link Out ? help Back to Top
Phytozome	Kalax.0045s0142.1.p

Publications ? help Back to Top
Heidari B,Nemie-Feyissa D,Kangasjärvi S,Lillo C Antagonistic regulation of flowering time through distinct regulatory subunits of protein phosphatase 2A. PLoS ONE, 2013. 8(7): p. e67987 [PMID:23976921] Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Crevillén P, et al. Epigenetic reprogramming that prevents transgenerational inheritance of the vernalized state. Nature, 2014. 515(7528): p. 587-90 [PMID:25219852] Yang H,Howard M,Dean C Physical coupling of activation and derepression activities to maintain an active transcriptional state at FLC. Proc. Natl. Acad. Sci. U.S.A., 2016. 113(33): p. 9369-74 [PMID:27482092]