PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; Saxifragales; Crassulaceae; Kalanchoe

Family

C2H2

Protein Properties

Length: 524aa MW: 58439.8 Da PI: 6.3739

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Kalax.0019s0059.1.p	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	21	8.8e-07	274	295	2	23
EETTTTEEESSHHHHHHHHHHT CS zf-C2H2 2 kCpdCgksFsrksnLkrHirtH 23 C++Cgk F+r nL+ H+r H Kalax.0019s0059.1.p 274 FCTICGKGFKRDANLRMHMRGH 295 6*******************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF57667	2.6E-5	272	297	No hit	No description
SMART	SM00355	0.0026	273	295	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	12.03	273	300	IPR007087	Zinc finger, C2H2
Gene3D	G3DSA:3.30.160.60	1.1E-5	274	324	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE pattern	PS00028	0	275	295	IPR007087	Zinc finger, C2H2
SMART	SM00355	75	322	355	IPR015880	Zinc finger, C2H2-like
SMART	SM00355	27	360	382	IPR015880	Zinc finger, C2H2-like

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0010044	Biological Process	response to aluminum ion
GO:0010447	Biological Process	response to acidic pH
GO:0005634	Cellular Component	nucleus
GO:0003676	Molecular Function	nucleic acid binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 524 aa Download sequence Send to blast
MERKDRIHTE NWMRSGVLEN QFSRKSSPDC QYFSIPNQHS DQVEWKNSPF MDYEMRTHES 60 ASGSITNSNH TSSTLGDRNR LPKIPDNMNA QSNPVLQAGA NANWDPNAML NNLSFLEVKI 120 HQLQDMVHLI VGCKCQVANG LDEVTAQQQQ LISADLTSII VQLISTAGSL LPSVTQNILA 180 ANPAIGQLDG ILLPSENGMR SNILPPCNGG AQLDELSKQS DALVKNQVTE QNSLVDEHEM 240 KDEEDVEEGE HLPPGSYEIL QLEKDEILAP HTHFCTICGK GFKRDANLRM HMRGHGDEYK 300 SPAALAKPNK ECTLEPVLIK RYSCPYFGCK RNKDHRKFQP LKTILCVKNH YKRSHCDKSF 360 TCSRCNTKKF SVIADLKTHE KHCGRDKWLC SCGTTFSRKD KLFGHIALFQ GHTPAIPLDD 420 KILAGTDQGE SSKLTSKVSG IQFNFSTNAP ISCGTSNQNM MDFKANLDDP VPCFSPVSFD 480 PCNLLAFNEF PRTTFEDSDT SFSFLIPGSF DYDQKSEGDS ELK*

Sequence ? help Back to Top

Protein Sequence Length: 524 aa Download sequence Send to blast

MERKDRIHTE NWMRSGVLEN QFSRKSSPDC QYFSIPNQHS DQVEWKNSPF MDYEMRTHES  60
ASGSITNSNH TSSTLGDRNR LPKIPDNMNA QSNPVLQAGA NANWDPNAML NNLSFLEVKI  120
HQLQDMVHLI VGCKCQVANG LDEVTAQQQQ LISADLTSII VQLISTAGSL LPSVTQNILA  180
ANPAIGQLDG ILLPSENGMR SNILPPCNGG AQLDELSKQS DALVKNQVTE QNSLVDEHEM  240
KDEEDVEEGE HLPPGSYEIL QLEKDEILAP HTHFCTICGK GFKRDANLRM HMRGHGDEYK  300
SPAALAKPNK ECTLEPVLIK RYSCPYFGCK RNKDHRKFQP LKTILCVKNH YKRSHCDKSF  360
TCSRCNTKKF SVIADLKTHE KHCGRDKWLC SCGTTFSRKD KLFGHIALFQ GHTPAIPLDD  420
KILAGTDQGE SSKLTSKVSG IQFNFSTNAP ISCGTSNQNM MDFKANLDDP VPCFSPVSFD  480
PCNLLAFNEF PRTTFEDSDT SFSFLIPGSF DYDQKSEGDS ELK*

Functional Description ? help Back to Top
Source	Description
UniProt	Probable transcription factor. Together with STOP2, plays a critical role in tolerance to major stress factors in acid soils such as proton H(+) and aluminum ion Al(3+). Required for the expression of genes in response to acidic stress (e.g. ALMT1 and MATE), and Al-activated citrate exudation. {ECO:0000269\|PubMed:17535918, ECO:0000269\|PubMed:18826429, ECO:0000269\|PubMed:19321711, ECO:0000269\|PubMed:23935008}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00196	ampDAP	Transfer from AT1G34370	Download

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By shock H(+) and Al(3+) treatments. {ECO:0000269\|PubMed:17535918}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_021647541.1	0.0	protein SENSITIVE TO PROTON RHIZOTOXICITY 1
Refseq	XP_021647542.1	0.0	protein SENSITIVE TO PROTON RHIZOTOXICITY 1
Swissprot	Q9C8N5	1e-179	STOP1_ARATH; Protein SENSITIVE TO PROTON RHIZOTOXICITY 1
TrEMBL	A5BSF5	0.0	A5BSF5_VITVI; Uncharacterized protein
STRING	VIT_18s0072g00840.t01	0.0	(Vitis vinifera)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G34370.2	1e-169	C2H2 family protein

Link Out ? help Back to Top
Phytozome	Kalax.0019s0059.1.p

Publications ? help Back to Top
Kobayashi Y, et al. Molecular and physiological analysis of Al³⁺ and H⁺ rhizotoxicities at moderately acidic conditions. Plant Physiol., 2013. 163(1): p. 180-92 [PMID:23839867] Yokosho K,Yamaji N,Ma JF Global transcriptome analysis of Al-induced genes in an Al-accumulating species, common buckwheat (Fagopyrum esculentum Moench). Plant Cell Physiol., 2014. 55(12): p. 2077-91 [PMID:25273892] Geng X, et al. LEUNIG_HOMOLOG transcriptional co-repressor mediates aluminium sensitivity through PECTIN METHYLESTERASE46-modulated root cell wall pectin methylesterification in Arabidopsis. Plant J., 2017. 90(3): p. 491-504 [PMID:28181322] Balzergue C, et al. Low phosphate activates STOP1-ALMT1 to rapidly inhibit root cell elongation. Nat Commun, 2017. 8: p. 15300 [PMID:28504266] Pelagio-Flores R,Esparza-Reynoso S,Garnica-Vergara A,López-Bucio J,Herrera-Estrella A Trichoderma-Induced Acidification Is an Early Trigger for Changes in Arabidopsis Root Growth and Determines Fungal Phytostimulation. Front Plant Sci, 2017. 8: p. 822 [PMID:28567051] Jiang F, et al. Identification and characterization of suppressor mutants of stop1. BMC Plant Biol., 2017. 17(1): p. 128 [PMID:28738784] Daspute AA, et al. Transcriptional Regulation of Aluminum-Tolerance Genes in Higher Plants: Clarifying the Underlying Molecular Mechanisms. Front Plant Sci, 2017. 8: p. 1358 [PMID:28848571] Sharma A,Wai CM,Ming R,Yu Q Diurnal Cycling Transcription Factors of Pineapple Revealed by Genome-Wide Annotation and Global Transcriptomic Analysis. Genome Biol Evol, 2017. 9(9): p. 2170-2190 [PMID:28922793] Zhang Y, et al. The Cell Cycle Checkpoint Regulator ATR Is Required for Internal Aluminum Toxicity-Mediated Root Growth Inhibition in Arabidopsis. Front Plant Sci, 2018. 9: p. 118 [PMID:29491872]