PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; Saxifragales; Crassulaceae; Kalanchoe

Family

G2-like

Protein Properties

Length: 473aa MW: 51319.7 Da PI: 6.2418

Description

G2-like family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Kaladp0040s0664.1.p	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	G2-like	103.1	1.7e-32	255	309	1	55
G2-like 1 kprlrWtpeLHerFveaveqLGGsekAtPktilelmkvkgLtlehvkSHLQkYRl 55 k+r+rWtpeLHe+Fv+av++LGGse+AtPk +l+ m+++gLt++hvkSHLQkYR+ Kaladp0040s0664.1.p 255 KARMRWTPELHEAFVQAVASLGGSERATPKGVLKRMNIEGLTIYHVKSHLQKYRT 309 68****************************************************8 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS51294	10.433	252	312	IPR017930	Myb domain
Gene3D	G3DSA:1.10.10.60	7.8E-29	255	310	IPR009057	Homeodomain-like
SuperFamily	SSF46689	4.3E-16	255	309	IPR009057	Homeodomain-like
TIGRFAMs	TIGR01557	1.4E-23	255	309	IPR006447	Myb domain, plants
Pfam	PF00249	4.7E-10	257	308	IPR001005	SANT/Myb domain
Pfam	PF14379	3.4E-25	342	388	IPR025756	MYB-CC type transcription factor, LHEQLE-containing domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 473 aa Download sequence Send to blast
MEARPIPIYN SGGKQHSGAC GAISSSLSVL PSHLDHNSPN FQDHQQASLR KGVMGGGSFM 60 RASPFISNNG MVGPLHSSSS GFSTDIQFSN VSPCSRNTST ISQSSINVTP FPPTHSSFSG 120 VLQSTASSQI NSANNISWCT DPQQEFFDFA SPGNHIQTGR KGSSAVMPTD DLGKQSDWQE 180 WADQLITSEE ALNANWNEYI CDVALENMDG ETGCIKKPSS DVQRQQPQVQ LQPTAPSSET 240 GNAGTPTSSA NGAVKARMRW TPELHEAFVQ AVASLGGSER ATPKGVLKRM NIEGLTIYHV 300 KSHLQKYRTA RFRPDPSEAG SSDKRSTSIE EISSLDLKSG IDITEALRLQ MEVQKRLHEQ 360 LEVQRNLQLR IEEQGRYLQQ MFEQQCKSMP DSVKAAMTPD GQQHSSDKLG VQEVSPNDNK 420 NPGSKNADSS TSLGENPCNQ VILPAKSSRE VDDIDMSQPS KRKKTGEPSE PN*

Sequence ? help Back to Top

Protein Sequence Length: 473 aa Download sequence Send to blast

MEARPIPIYN SGGKQHSGAC GAISSSLSVL PSHLDHNSPN FQDHQQASLR KGVMGGGSFM  60
RASPFISNNG MVGPLHSSSS GFSTDIQFSN VSPCSRNTST ISQSSINVTP FPPTHSSFSG  120
VLQSTASSQI NSANNISWCT DPQQEFFDFA SPGNHIQTGR KGSSAVMPTD DLGKQSDWQE  180
WADQLITSEE ALNANWNEYI CDVALENMDG ETGCIKKPSS DVQRQQPQVQ LQPTAPSSET  240
GNAGTPTSSA NGAVKARMRW TPELHEAFVQ AVASLGGSER ATPKGVLKRM NIEGLTIYHV  300
KSHLQKYRTA RFRPDPSEAG SSDKRSTSIE EISSLDLKSG IDITEALRLQ MEVQKRLHEQ  360
LEVQRNLQLR IEEQGRYLQQ MFEQQCKSMP DSVKAAMTPD GQQHSSDKLG VQEVSPNDNK  420
NPGSKNADSS TSLGENPCNQ VILPAKSSRE VDDIDMSQPS KRKKTGEPSE PN*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
6j4k_A	4e-31	255	313	2	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j4k_B	4e-31	255	313	2	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_A	4e-31	255	313	2	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_C	4e-31	255	313	2	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_D	4e-31	255	313	2	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_F	4e-31	255	313	2	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_H	4e-31	255	313	2	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_J	4e-31	255	313	2	60	Protein PHOSPHATE STARVATION RESPONSE 1
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Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor involved in phosphate starvation signaling (PubMed:11511543, PubMed:17927693, PubMed:26586833). Binds as a dimer to P1BS, an imperfect palindromic sequence 5'-GNATATNC-3', to promote the expression of inorganic phosphate (Pi) starvation-responsive genes (PubMed:11511543, PubMed:20838596, PubMed:26586833). SPX1 is a competitive inhibitor of this DNA-binding (PubMed:25271326). PHR1 binding to its targets is low Pi-dependent (PubMed:25271326). Regulates the expression of miR399 (PubMed:20838596). Regulates the expression of IPS1 (At3g09922), a non-coding RNA that mimics the target of miR399 to block the cleavage of PHO2 under Pi-deficient conditions (PubMed:17643101). Regulates lipid remodeling and triacylglycerol accumulation during phosphorus starvation (PubMed:25680792). Required for the shoot-specific hypoxic response (PubMed:24753539). Regulates FER1 expression upon phosphate starvation, linking iron and phosphate homeostasis (PubMed:23788639). Contributes to the homeostasis of both sulfate and phosphate in plants under phosphate deficiency (PubMed:21261953). Required for adaptation to high light and retaining functional photosynthesis during phosphate starvation (PubMed:21910737). Involved in the coregulation of Zn and Pi homeostasis (PubMed:24420568). {ECO:0000269\|PubMed:11511543, ECO:0000269\|PubMed:17643101, ECO:0000269\|PubMed:17927693, ECO:0000269\|PubMed:20838596, ECO:0000269\|PubMed:21261953, ECO:0000269\|PubMed:21910737, ECO:0000269\|PubMed:23788639, ECO:0000269\|PubMed:24420568, ECO:0000269\|PubMed:24753539, ECO:0000269\|PubMed:25271326, ECO:0000269\|PubMed:25680792, ECO:0000269\|PubMed:26586833}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Only moderately up-regulated by Pi starvation. {ECO:0000269\|PubMed:11511543}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_002270511.1	1e-141	PREDICTED: protein PHOSPHATE STARVATION RESPONSE 1
Swissprot	Q94CL7	3e-90	PHR1_ARATH; Protein PHOSPHATE STARVATION RESPONSE 1
TrEMBL	F6HZP9	1e-140	F6HZP9_VITVI; Uncharacterized protein
STRING	VIT_07s0005g04120.t01	1e-141	(Vitis vinifera)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT4G28610.1	4e-89	phosphate starvation response 1

Link Out ? help Back to Top
Phytozome	Kaladp0040s0664.1.p

Publications ? help Back to Top
Duarte JM, et al. Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. Mol. Biol. Evol., 2006. 23(2): p. 469-78 [PMID:16280546] Matsui K,Togami J,Mason JG,Chandler SF,Tanaka Y Enhancement of phosphate absorption by garden plants by genetic engineering: a new tool for phytoremediation. Biomed Res Int, 2013. 2013: p. 182032 [PMID:23984322] Jost R, et al. Differentiating phosphate-dependent and phosphate-independent systemic phosphate-starvation response networks in Arabidopsis thaliana through the application of phosphite. J. Exp. Bot., 2015. 66(9): p. 2501-14 [PMID:25697796] Zhou Z, et al. SPX proteins regulate Pi homeostasis and signaling in different subcellular level. Plant Signal Behav, 2015. 10(9): p. e1061163 [PMID:26224365] Bonnot C, et al. A chemical genetic strategy identify the PHOSTIN, a synthetic molecule that triggers phosphate starvation responses in Arabidopsis thaliana. New Phytol., 2016. 209(1): p. 161-76 [PMID:26243630] Khan GA,Vogiatzaki E,Glauser G,Poirier Y Phosphate Deficiency Induces the Jasmonate Pathway and Enhances Resistance to Insect Herbivory. Plant Physiol., 2016. 171(1): p. 632-44 [PMID:27016448] Velasco VM, et al. Acclimation of the crucifer Eutrema salsugineum to phosphate limitation is associated with constitutively high expression of phosphate-starvation genes. Plant Cell Environ., 2016. 39(8): p. 1818-34 [PMID:27038434] Yong-Villalobos L, et al. Phosphate starvation induces DNA methylation in the vicinity of cis-acting elements known to regulate the expression of phosphate-responsive genes. Plant Signal Behav, 2016. 11(5): p. e1173300 [PMID:27185363] Li Y,Wu H,Fan H,Zhao T,Ling HQ Characterization of the AtSPX3 Promoter Elucidates its Complex Regulation in Response to Phosphorus Deficiency. Plant Cell Physiol., 2016. 57(8): p. 1767-78 [PMID:27382128] Zhang H,Huang L,Hong Y,Song F BOTRYTIS-INDUCED KINASE1, a plasma membrane-localized receptor-like protein kinase, is a negative regulator of phosphate homeostasis in Arabidopsis thaliana. BMC Plant Biol., 2016. 16(1): p. 152 [PMID:27389008] Yuan J, et al. Systematic characterization of novel lncRNAs responding to phosphate starvation in Arabidopsis thaliana. BMC Genomics, 2016. 17: p. 655 [PMID:27538394] Linn J, et al. Root Cell-Specific Regulators of Phosphate-Dependent Growth. Plant Physiol., 2017. 174(3): p. 1969-1989 [PMID:28465462] Aleksza D,Horváth GV,Sándor G,Szabados L Proline Accumulation Is Regulated by Transcription Factors Associated with Phosphate Starvation. Plant Physiol., 2017. 175(1): p. 555-567 [PMID:28765275] Liu Y, et al. Light and Ethylene Coordinately Regulate the Phosphate Starvation Response through Transcriptional Regulation of PHOSPHATE STARVATION RESPONSE1. Plant Cell, 2017. 29(9): p. 2269-2284 [PMID:28842534] Qi W,Manfield IW,Muench SP,Baker A AtSPX1 affects the AtPHR1-DNA-binding equilibrium by binding monomeric AtPHR1 in solution. Biochem. J., 2017. 474(21): p. 3675-3687 [PMID:28887383] Huang KL, et al. The ARF7 and ARF19 Transcription Factors Positively Regulate PHOSPHATE STARVATION RESPONSE1 in Arabidopsis Roots. Plant Physiol., 2018. 178(1): p. 413-427 [PMID:30026290] Jiang M, et al. Structural basis for the Target DNA recognition and binding by the MYB domain of phosphate starvation response 1. FEBS J., 2019. [PMID:30974511]