PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID KZV54605.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Gesneriaceae; Didymocarpoideae; Trichosporeae; Loxocarpinae; Dorcoceras
Family bHLH
Protein Properties Length: 654aa    MW: 71477.6 Da    PI: 5.4381
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
KZV54605.1genomeCNUView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH38.71.8e-12477522454
                 HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS
         HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 
                 +h e+Er+RR+++N++f  Lr ++P+       K++Ka+ L  A+ YI++L
  KZV54605.1 477 NHVEAERQRREKLNQRFYALRAVVPNV-----SKMDKASLLGDAITYINDL 522
                 799***********************6.....5****************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142152.2E-5473251IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088817.091473522IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474595.89E-18474543IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000831.21E-15476527No hitNo description
Gene3DG3DSA:4.10.280.109.6E-19477543IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000105.9E-10477522IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003534.6E-16479528IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd146860.00381518548No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 654 aa     Download sequence    Send to blast
MNSWTATSDT ATIAAAAGDG EASIMDSFMS SSSDLSYFWP SQQPFYAATP NPPPSTDHFK  60
PTSAAQVFNQ ETLQQRLLAL IEGARESWTY AIFWQSSVVE YGGPSLGWGD GYYKGEENKV  120
KRSTVYSPAE QDHRKKVIRE LNSMISGSQA SPDDAVDEEV TDTEWFFLIS MTQSFAYGSG  180
LPGQAMYSSS PVWVTGTERL LASHCERAQQ AQGFGLQTLV CIPSPNGVVE LGSTEPIFQS  240
SDLMNKVRFL FNFNGMEMGS GSGSGSWALP ENDPSALWLT EPSSSAVDTK DSLNTNNDNN  300
NVQVSSVPSS ITSNLIVFGN ENPSSSTVTD NPLQQNQGFL AKDTRFSKFG PSGTASNVRK  360
GEILSFGESS KRSICGGNVN LFGVQEENHD NSSTKNKKRS PVSRGIHDEG MLSFTSGAIL  420
QTSGTVKTDT NGGIESDHSD LEVSVVKDAE SSRVVDPEKR PRKRGRKPAN GREEPLNHVE  480
AERQRREKLN QRFYALRAVV PNVSKMDKAS LLGDAITYIN DLKAKLQNVE SENDDMRSQL  540
ESMKKELAAK GSVTSPMSHD QKKSSICGIT AIDMDIDVKI IGWDAMIRVQ CSKKNHPAAR  600
LMVALKELNL DVHHASVSVV NDLMIQQATV KMEGYFFSQD QLKAALTSKI AEKR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4rqw_A2e-67682544195Transcription factor MYC3
4rqw_B2e-67682544195Transcription factor MYC3
4rs9_A2e-67682544195Transcription factor MYC3
4yz6_A2e-67682544195Transcription factor MYC3
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1458466KRPRKRGRK
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator that binds to the G-box motif (5'-AACGTG-3') found in the promoter of the jasmonate-induced gene LAPA1 (PubMed:15231736). Acts as negative regulator of blue light-mediated photomorphogenesis and positively regulates root growth (PubMed:24483714). Promotes growth in response to the phytohormones abscisic acid (ABA) and jasmonate (JA) (PubMed:24483714). Binds to the G-box motif (5'-CACGTG-3') of the RBCS-3A gene promoter (PubMed:24483714). Acts downstream of the jasmonate (JA) receptor to orchestrate JA-mediated activation of plant responses (PubMed:28733419). Positively regulates both wound-responsive and pathogen-responsive genes through MYC2-targeted transcription factors (MTFs) involved in early response to JA (PubMed:28733419). With JA2L forms a transcription module that regulates wounding-responsive genes (PubMed:28733419). With ERF.C3 forms a transcription module that regulates pathogen-responsive genes (PubMed:28733419). Plays a critical role in orchestrating JA-mediated defense gene expression during Botrytis cinerea infection (PubMed:28733419). Regulates negatively defense responses to root-knot nematodes, potentially by mediating crosstalk among the hormones strigolactones, abscisic acid (ABA) and jasmonate (JA) (PubMed:30576511). Regulates the termination of JA-mediated defense responses by specifically binding the G-box (5'-CACATG-3') motifs in the promoters of MTB1, MTB2 and MTB3, which are transcription factors that negatively regulates JA signaling (PubMed:30610166). May be involved in JA-induced chilling tolerance, possibly by ameliorating the antioxidant enzyme system of fruit and increasing proline and lycopene levels (PubMed:29528226). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:24483714, ECO:0000269|PubMed:28733419, ECO:0000269|PubMed:29528226, ECO:0000269|PubMed:30576511, ECO:0000269|PubMed:30610166}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapKZV54605.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by methyl jasmonate (PubMed:15231736, PubMed:28733419). Induced by wounding (PubMed:15231736). Induced by infection with the fungal pathogen Botrytis cinerea (PubMed:28733419). Induced in fruit by storage in cold (PubMed:29528226). Induced by hydrogen peroxide and infection with root-knot nematodes (PubMed:30576511). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:28733419, ECO:0000269|PubMed:29528226, ECO:0000269|PubMed:30576511}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011082365.10.0transcription factor MYC4-like
SwissprotA0A3Q7HRZ60.0MYC2_SOLLC; Transcription factor MYC2
TrEMBLA0A2Z7D5920.0A0A2Z7D592_9LAMI; Uncharacterized protein
STRINGXP_009609942.10.0(Nicotiana tomentosiformis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA33002449
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G32640.11e-168bHLH family protein
Publications ? help Back to Top
  1. Tomato Genome Consortium
    The tomato genome sequence provides insights into fleshy fruit evolution.
    Nature, 2012. 485(7400): p. 635-41
    [PMID:22660326]
  2. Gupta N,Prasad VB,Chattopadhyay S
    LeMYC2 acts as a negative regulator of blue light mediated photomorphogenic growth, and promotes the growth of adult tomato plants.
    BMC Plant Biol., 2014. 14: p. 38
    [PMID:24483714]
  3. Sun H,Fan HJ,Ling HQ
    Genome-wide identification and characterization of the bHLH gene family in tomato.
    BMC Genomics, 2015. 16: p. 9
    [PMID:25612924]
  4. Du M, et al.
    MYC2 Orchestrates a Hierarchical Transcriptional Cascade That Regulates Jasmonate-Mediated Plant Immunity in Tomato.
    Plant Cell, 2017. 29(8): p. 1883-1906
    [PMID:28733419]
  5. Min D, et al.
    SlMYC2 Involved in Methyl Jasmonate-Induced Tomato Fruit Chilling Tolerance.
    J. Agric. Food Chem., 2018. 66(12): p. 3110-3117
    [PMID:29528226]
  6. Xu X, et al.
    Strigolactones positively regulate defense against root-knot nematodes in tomato.
    J. Exp. Bot., 2019. 70(4): p. 1325-1337
    [PMID:30576511]
  7. Liu Y, et al.
    MYC2 Regulates the Termination of Jasmonate Signaling via an Autoregulatory Negative Feedback Loop.
    Plant Cell, 2019. 31(1): p. 106-127
    [PMID:30610166]