PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Jatropheae; Jatropha

Family

C2H2

Protein Properties

Length: 597aa MW: 65761.9 Da PI: 7.9742

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Jcr4S01281.10	genome	Kazusa	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	16.9	1.7e-05	92	114	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 ++C++C+k F r nL+ H r H Jcr4S01281.10 92 FVCEICNKGFQRDQNLQLHRRGH 114 89*******************88 PP
2	zf-C2H2	15.3	5.6e-05	168	190	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 +kC +C+k + +s+ k H++t+ Jcr4S01281.10 168 WKCDKCSKKYAVQSDWKAHQKTC 190 58*******************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:3.30.160.60	2.0E-5	91	114	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamily	SSF57667	6.15E-8	91	114	No hit	No description
SMART	SM00355	0.017	92	114	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	10.949	92	114	IPR007087	Zinc finger, C2H2
PROSITE pattern	PS00028	0	94	114	IPR007087	Zinc finger, C2H2
SMART	SM00355	98	133	163	IPR015880	Zinc finger, C2H2-like
Gene3D	G3DSA:3.30.160.60	7.1E-5	156	189	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamily	SSF57667	6.15E-8	163	189	No hit	No description
SMART	SM00355	94	168	188	IPR015880	Zinc finger, C2H2-like

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003676	Molecular Function	nucleic acid binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 597 aa Download sequence Send to blast
MSNITGDEGS FSSGNTGDEV QQLQETQQEQ HLQLQNHFHG SNNSAATNSN GSTSQEQQPQ 60 TVKKKRNLPG TPDPNAEVIA LSPTTLMATN RFVCEICNKG FQRDQNLQLH RRGHNLPWKL 120 RQRTTTEVRK RVYICPEPTC VHHNPARALG DLTGIKKHFS RKHGEKKWKC DKCSKKYAVQ 180 SDWKAHQKTC GTREYKCDCG TIFSRRDSFI THRAFCDALA EENNEVNQQG LMGNTGSNLQ 240 TQMPDLMSSL PLTTNANNNT PIGISDFNSF EPKNPLKSLP QELVPMPFKS TNMGAGGGMF 300 SSSSGTLFAG PRSISSTSSS LQLSSNSSSG YNYMQEGKNG CQISGSAHMS ATALLQKAAQ 360 MGATASNSTM NSPMMQKSFA SSMTAGPEQI SSIRPPQSYG HLQQQQQHGA TSSYDHHHHH 420 FLSQPDHQNQ ANMVGINNMS SGGFNDNNQT MQKSPQDMSQ YFETNSTSSA MASSGMNNMG 480 IFSGMFIGTD QNPGFMKGIE HEDSSGSNTL IHGRAVNTGP SRFVGSNGEG VHDMMTRDFM 540 GIGGSRPVNL HEQQQQQRLE MEAMNQQQQQ QRMPMMNHFQ QQISLGESAM EKPIWDV

Sequence ? help Back to Top

Protein Sequence Length: 597 aa Download sequence Send to blast

MSNITGDEGS FSSGNTGDEV QQLQETQQEQ HLQLQNHFHG SNNSAATNSN GSTSQEQQPQ  60
TVKKKRNLPG TPDPNAEVIA LSPTTLMATN RFVCEICNKG FQRDQNLQLH RRGHNLPWKL  120
RQRTTTEVRK RVYICPEPTC VHHNPARALG DLTGIKKHFS RKHGEKKWKC DKCSKKYAVQ  180
SDWKAHQKTC GTREYKCDCG TIFSRRDSFI THRAFCDALA EENNEVNQQG LMGNTGSNLQ  240
TQMPDLMSSL PLTTNANNNT PIGISDFNSF EPKNPLKSLP QELVPMPFKS TNMGAGGGMF  300
SSSSGTLFAG PRSISSTSSS LQLSSNSSSG YNYMQEGKNG CQISGSAHMS ATALLQKAAQ  360
MGATASNSTM NSPMMQKSFA SSMTAGPEQI SSIRPPQSYG HLQQQQQHGA TSSYDHHHHH  420
FLSQPDHQNQ ANMVGINNMS SGGFNDNNQT MQKSPQDMSQ YFETNSTSSA MASSGMNNMG  480
IFSGMFIGTD QNPGFMKGIE HEDSSGSNTL IHGRAVNTGP SRFVGSNGEG VHDMMTRDFM  540
GIGGSRPVNL HEQQQQQRLE MEAMNQQQQQ QRMPMMNHFQ QQISLGESAM EKPIWDV

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5b3h_C	3e-33	164	222	3	61	Zinc finger protein JACKDAW
5b3h_F	3e-33	164	222	3	61	Zinc finger protein JACKDAW
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor that acts as a positive regulator of gibberellin (GA) action, homeostasis and signaling. GA converts the GAF1 complex from transcriptional activator to repressor via the degradation of DELLA proteins. {ECO:0000269\|PubMed:25035403}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_012082706.1	0.0	protein indeterminate-domain 2-like
Swissprot	Q9SCQ6	1e-113	IDD2_ARATH; Zinc finger protein GAI-ASSOCIATED FACTOR 1
TrEMBL	A0A2C9VTY7	0.0	A0A2C9VTY7_MANES; Uncharacterized protein
STRING	cassava4.1_030413m	0.0	(Manihot esculenta)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF2192	30	85

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G03840.1	2e-99	C2H2 family protein

Publications ? help Back to Top
Fukazawa J, et al. DELLAs function as coactivators of GAI-ASSOCIATED FACTOR1 in regulation of gibberellin homeostasis and signaling in Arabidopsis. Plant Cell, 2014. 26(7): p. 2920-38 [PMID:25035403] Moreno-Risueno MA, et al. Transcriptional control of tissue formation throughout root development. Science, 2015. 350(6259): p. 426-30 [PMID:26494755] Khare D, et al. Root avoidance of toxic metals requires the GeBP-LIKE 4 transcription factor in Arabidopsis thaliana. New Phytol., 2017. 213(3): p. 1257-1273 [PMID:27768815]