PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Jcr4S00699.20

Common Name

JCGZ_01133

Organism

Jatropha curcas

Taxonomic ID

180498

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Jatropheae; Jatropha

Family

bHLH

Protein Properties

Length: 419aa MW: 47669.6 Da PI: 5.472

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Jcr4S00699.20	genome	Kazusa	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	38	2.9e-12	212	263	1	55
CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS HLH 1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 +r++h ++Er+RR+++N+ + Lr+l+P + + ++ + a+i A+e++++L+ Jcr4S00699.20 212 QRMTHIAVERNRRKQMNEHLRVLRSLMPGS---YVQRGDQASIIGGAIEFVRELE 263 79**************************...9***************9995 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
CDD	cd00083	1.70E-12	210	267	No hit	No description
Gene3D	G3DSA:4.10.280.10	1.5E-13	210	266	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamily	SSF47459	2.22E-16	211	277	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profile	PS50888	15.428	211	262	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Pfam	PF00010	1.3E-9	212	263	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SMART	SM00353	3.4E-9	217	268	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd04873	0.00132	345	409	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0010377	Biological Process	guard cell fate commitment
GO:0045597	Biological Process	positive regulation of cell differentiation
GO:0045893	Biological Process	positive regulation of transcription, DNA-templated
GO:0051782	Biological Process	negative regulation of cell division
GO:0005634	Cellular Component	nucleus
GO:0046983	Molecular Function	protein dimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 419 aa Download sequence Send to blast
MLYCSELVGF LQATFTGLDY SLDHHHHQEQ EHELIKSRIG ESSGDNTNGM IDYMLRNPHN 60 HHHQQQISAG FCSSTSLDKL SFADVMQFAD FGPKLALNQT KISEEEETGI DPVYFLKFPV 120 LNDKREDQSL MVPQLNGENE ERFKGVVNGA ENRIGEERII REEEEARVSD NTSVQLQFVG 180 DQDLQNKNAI TEVKNKRKRP RTIKTSEEVE SQRMTHIAVE RNRRKQMNEH LRVLRSLMPG 240 SYVQRGDQAS IIGGAIEFVR ELEQLLQCLE SQKRRRLYGE ASRQMGDNSS SAIQQPQSPF 300 FPPNLPISND QMKLMEFETG LHEETAENKS CLADVEVKLL GFDAMIKILS RRRPGQLIKT 360 IAALEDLQLN ILHTNITTIE QTVLYSFNVK IASESGFTAE DIASSVQQIF SFIHANSSM

Sequence ? help Back to Top

Protein Sequence Length: 419 aa Download sequence Send to blast

MLYCSELVGF LQATFTGLDY SLDHHHHQEQ EHELIKSRIG ESSGDNTNGM IDYMLRNPHN  60
HHHQQQISAG FCSSTSLDKL SFADVMQFAD FGPKLALNQT KISEEEETGI DPVYFLKFPV  120
LNDKREDQSL MVPQLNGENE ERFKGVVNGA ENRIGEERII REEEEARVSD NTSVQLQFVG  180
DQDLQNKNAI TEVKNKRKRP RTIKTSEEVE SQRMTHIAVE RNRRKQMNEH LRVLRSLMPG  240
SYVQRGDQAS IIGGAIEFVR ELEQLLQCLE SQKRRRLYGE ASRQMGDNSS SAIQQPQSPF  300
FPPNLPISND QMKLMEFETG LHEETAENKS CLADVEVKLL GFDAMIKILS RRRPGQLIKT  360
IAALEDLQLN ILHTNITTIE QTVLYSFNVK IASESGFTAE DIASSVQQIF SFIHANSSM

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	212	223	RMTHIAVERNRR
2	272	276	KRRRL

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269\|PubMed:17088607, ECO:0000269\|PubMed:17183265, ECO:0000269\|PubMed:17183267, ECO:0000269\|PubMed:24571519, ECO:0000269\|PubMed:24654956}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269\|PubMed:22442411}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_012071156.1	0.0	transcription factor FAMA isoform X1
Swissprot	Q56YJ8	1e-154	FAMA_ARATH; Transcription factor FAMA
TrEMBL	A0A067KT33	0.0	A0A067KT33_JATCU; Uncharacterized protein
STRING	cassava4.1_024031m	0.0	(Manihot esculenta)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF10489	33	40

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G24140.1	1e-143	bHLH family protein

Publications ? help Back to Top
Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. Differentiation, 2010. 80(1): p. 1-8 [PMID:20219281] Zhang L, et al. Global analysis of gene expression profiles in physic nut (Jatropha curcas L.) seedlings exposed to salt stress. PLoS ONE, 2014. 9(5): p. e97878 [PMID:24837971] Matos JL, et al. Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module. Elife, 2015. [PMID:25303364] Chen L, et al. NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis. Development, 2016. 143(9): p. 1600-11 [PMID:26989174] Lee JH,Jung JH,Park CM Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis. Plant Cell, 2017. 29(11): p. 2817-2830 [PMID:29070509] Han X, et al. Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons. Plant Physiol., 2018. 176(4): p. 2871-2885 [PMID:29496884] Li X,Yang R,Chen H The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA. PLoS ONE, 2018. 13(3): p. e0193458 [PMID:29513733]