PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Cannabaceae; Humulus

Family

C2H2

Protein Properties

Length: 599aa MW: 65127.4 Da PI: 8.3034

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
HL.SW.v1.0.G037712.1	genome	HOPBASE	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	16.9	1.7e-05	108	130	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 ++C++C+k F r nL+ H r H HL.SW.v1.0.G037712.1 108 FVCEICNKGFQRDQNLQLHRRGH 130 89*******************88 PP
2	zf-C2H2	15.3	5.6e-05	184	206	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 +kC +C+k + +s+ k H++t+ HL.SW.v1.0.G037712.1 184 WKCDKCSKKYAVQSDWKAHQKTC 206 58*******************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF57667	7.38E-8	107	130	No hit	No description
Gene3D	G3DSA:3.30.160.60	2.0E-5	107	130	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profile	PS50157	10.949	108	130	IPR007087	Zinc finger, C2H2
SMART	SM00355	0.017	108	130	IPR015880	Zinc finger, C2H2-like
PROSITE pattern	PS00028	0	110	130	IPR007087	Zinc finger, C2H2
SMART	SM00355	98	149	179	IPR015880	Zinc finger, C2H2-like
Gene3D	G3DSA:3.30.160.60	7.2E-5	172	205	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamily	SSF57667	7.38E-8	179	205	No hit	No description
SMART	SM00355	94	184	204	IPR015880	Zinc finger, C2H2-like

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003676	Molecular Function	nucleic acid binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 599 aa Download sequence Send to blast
MSNITATGEE GSFSSGNNNN NNNNDHLNST TTGDEEVIQG NQQKKQIHFH GSNSSIPSAT 60 TTLSSNSNDS SSQQPVLPKK KRNLPGTPDP NAEVIALSPT TLMATNRFVC EICNKGFQRD 120 QNLQLHRRGH NLPWKLRQRT TTEVKKRVYI CPEPTCVHHN PARALGDLTG IKKHFSRKHG 180 EKKWKCDKCS KKYAVQSDWK AHQKTCGTRE YKCDCGTIFS RRDSFITHRA FCDALAEENN 240 KVNQGLMNNN NMGPKLLSQE TQMPDLMPSM PLSSNASING LSDFKSIPQE LIPMPFKPMN 300 SVVTGGMFST SSGPLFGSPR GLSTSSASSL QLSSNSSSGF NYLQDNKNVS SPILAAGSAH 360 MSATALLQKA AQMGATASNS SINSPMIQKS FGSSMASPHI SHDQLSPVKQ AQMQLRPINP 420 AYDHHFQSQP SDHSSMVGID GGEGGFNHTH KSQQEISHLF GPNGHDMGMY SQMFMNNTSS 480 TTILEQEDSI NSSSIHGKFA IERNTAGLSR FAETGGGGGG GSGSGNGDDD RIVVDFMGIG 540 EPRPGSGMHE QQQQRLDHHQ LEAMRQNRLP PMMNNHPFQQ QVSHGDSGME KSSIWGDV*

Sequence ? help Back to Top

Protein Sequence Length: 599 aa Download sequence Send to blast

MSNITATGEE GSFSSGNNNN NNNNDHLNST TTGDEEVIQG NQQKKQIHFH GSNSSIPSAT  60
TTLSSNSNDS SSQQPVLPKK KRNLPGTPDP NAEVIALSPT TLMATNRFVC EICNKGFQRD  120
QNLQLHRRGH NLPWKLRQRT TTEVKKRVYI CPEPTCVHHN PARALGDLTG IKKHFSRKHG  180
EKKWKCDKCS KKYAVQSDWK AHQKTCGTRE YKCDCGTIFS RRDSFITHRA FCDALAEENN  240
KVNQGLMNNN NMGPKLLSQE TQMPDLMPSM PLSSNASING LSDFKSIPQE LIPMPFKPMN  300
SVVTGGMFST SSGPLFGSPR GLSTSSASSL QLSSNSSSGF NYLQDNKNVS SPILAAGSAH  360
MSATALLQKA AQMGATASNS SINSPMIQKS FGSSMASPHI SHDQLSPVKQ AQMQLRPINP  420
AYDHHFQSQP SDHSSMVGID GGEGGFNHTH KSQQEISHLF GPNGHDMGMY SQMFMNNTSS  480
TTILEQEDSI NSSSIHGKFA IERNTAGLSR FAETGGGGGG GSGSGNGDDD RIVVDFMGIG  540
EPRPGSGMHE QQQQRLDHHQ LEAMRQNRLP PMMNNHPFQQ QVSHGDSGME KSSIWGDV*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5b3h_C	6e-35	180	250	3	72	Zinc finger protein JACKDAW
5b3h_F	6e-35	180	250	3	72	Zinc finger protein JACKDAW
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor that acts as a positive regulator of gibberellin (GA) action, homeostasis and signaling. GA converts the GAF1 complex from transcriptional activator to repressor via the degradation of DELLA proteins. {ECO:0000269\|PubMed:25035403}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_024447996.1	0.0	protein indeterminate-domain 2
Swissprot	Q9SCQ6	1e-116	IDD2_ARATH; Zinc finger protein GAI-ASSOCIATED FACTOR 1
TrEMBL	A0A2P5FFN8	0.0	A0A2P5FFN8_TREOI; TFIIH C1-like domain containing protein
STRING	POPTR_0002s20950.1	0.0	(Populus trichocarpa)
STRING	cassava4.1_030413m	0.0	(Manihot esculenta)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF2192	30	85

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G50700.1	1e-103	indeterminate(ID)-domain 2

Publications ? help Back to Top
Fukazawa J, et al. DELLAs function as coactivators of GAI-ASSOCIATED FACTOR1 in regulation of gibberellin homeostasis and signaling in Arabidopsis. Plant Cell, 2014. 26(7): p. 2920-38 [PMID:25035403] Moreno-Risueno MA, et al. Transcriptional control of tissue formation throughout root development. Science, 2015. 350(6259): p. 426-30 [PMID:26494755] Khare D, et al. Root avoidance of toxic metals requires the GeBP-LIKE 4 transcription factor in Arabidopsis thaliana. New Phytol., 2017. 213(3): p. 1257-1273 [PMID:27768815]