PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID HL.SW.v1.0.G025417.1
Organism
Humulus lupulus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Cannabaceae; Humulus
Family bHLH
Protein Properties Length: 501aa    MW: 55053.8 Da    PI: 5.9034
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
HL.SW.v1.0.G025417.1genomeHOPBASEView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH39.78.7e-13354400455
                           HHHHHHHHHHHHHHHHHHHHHCTSCC.C...TTS-STCHHHHHHHHHHHHHHH CS
                   HLH   4 ahnerErrRRdriNsafeeLrellPk.askapskKlsKaeiLekAveYIksLq 55 
                           +h e+Er+RR+++N++f  Lr ++P+ +      K++Ka+ L  A+ YI +Lq
  HL.SW.v1.0.G025417.1 354 NHVEAERQRREKLNQRFYALRAVVPNiS------KMDKASLLGDAITYITDLQ 400
                           799***********************66......*****************99 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142153.7E-4249233IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088816.831350399IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000835.65E-15353404No hitNo description
SuperFamilySSF474592.88E-18353419IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000102.9E-10354400IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.108.9E-18354419IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003533.1E-15356405IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 501 aa     Download sequence    Send to blast
MGEKFWVKIE DKVMVESVVG TEACQFLISL ASDNGISGFN TPAGDLGVQQ GLCQLVESCN  60
LNYAIFWRVV NLKSGGAALI WGDGHCRTQK GGGAAEKSSS EGGNFDGSEN KKELKKRVLE  120
KLHACFGGLD EDNYARKLDG VSDLEMFYLT SMYYKYQVDS VCGPGESYKS GKAIWASDLS  180
NCSHHYQSRS FLARVAGFQT VVFVPVNSGV VELGTVNSTP EDQGVVDMVK NIFGVGSSSS  240
SQQTTKTFPK IFGHELSLGS TKSQSVNINF SPKVEDDSAF PSESFDLQAI GSSNGRNDSN  300
EMKLFPQMLV GGFNALTRVT GVEPPKDDAL PQLDERKPRK RGRKPANGRE EPLNHVEAER  360
QRREKLNQRF YALRAVVPNI SKMDKASLLG DAITYITDLQ TKIRVMETEK QMGTDKQQQF  420
SVPEIDFQSR QEDAVVRMSC PLDSHPVSNV IKAFREHQIV AQESDVSTNE NDRIVHTFSI  480
QTQGGDAEQL KEKLLAALSN *
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5gnj_A5e-29348410264Transcription factor MYC2
5gnj_B5e-29348410264Transcription factor MYC2
5gnj_E5e-29348410264Transcription factor MYC2
5gnj_F5e-29348410264Transcription factor MYC2
5gnj_G5e-29348410264Transcription factor MYC2
5gnj_I5e-29348410264Transcription factor MYC2
5gnj_M5e-29348410264Transcription factor MYC2
5gnj_N5e-29348410264Transcription factor MYC2
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1335343RKPRKRGRK
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor that negatively regulates jasmonate (JA) signaling (PubMed:30610166). Negatively regulates JA-dependent response to wounding, JA-induced expression of defense genes, JA-dependent responses against herbivorous insects, and JA-dependent resistance against Botrytis cinerea infection (PubMed:30610166). Plays a positive role in resistance against the bacterial pathogen Pseudomonas syringae pv tomato DC3000 (PubMed:30610166). {ECO:0000269|PubMed:30610166}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00099PBMTransfer from AT4G16430Download
Motif logo
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by wounding, feeding with herbivorous insects, infection with the fungal pathogen Botrytis cinerea and infection with the bacterial pathogen Pseudomonas syringae pv tomato DC3000. {ECO:0000269|PubMed:30610166}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_010100069.10.0transcription factor bHLH3
SwissprotA0A3Q7H2160.0MTB3_SOLLC; Transcription factor MTB3
TrEMBLA0A2P5FB930.0A0A2P5FB93_TREOI; Basic helix-loop-helix transcription factor
STRINGXP_010100069.10.0(Morus notabilis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF82633445
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G16430.11e-163bHLH family protein
Publications ? help Back to Top
  1. Tomato Genome Consortium
    The tomato genome sequence provides insights into fleshy fruit evolution.
    Nature, 2012. 485(7400): p. 635-41
    [PMID:22660326]
  2. Sun H,Fan HJ,Ling HQ
    Genome-wide identification and characterization of the bHLH gene family in tomato.
    BMC Genomics, 2015. 16: p. 9
    [PMID:25612924]
  3. Liu Y, et al.
    MYC2 Regulates the Termination of Jasmonate Signaling via an Autoregulatory Negative Feedback Loop.
    Plant Cell, 2019. 31(1): p. 106-127
    [PMID:30610166]