PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID HL.SW.v1.0.G005686.1
Organism
Humulus lupulus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Cannabaceae; Humulus
Family GRF
Protein Properties Length: 622aa    MW: 66201 Da    PI: 8.3676
Description GRF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
HL.SW.v1.0.G005686.1genomeHOPBASEView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1WRC76.52.6e-24239283145
                   WRC   1 daepgrCrRtDGKkWRCsrrvlegkklCErHlhrgrsrsrkskee 45 
                           d+epgrCrRtDGKkWRCsr++++++k+CErH++rgr+rsrk++e 
  HL.SW.v1.0.G005686.1 239 DPEPGRCRRTDGKKWRCSRDAVADQKYCERHINRGRHRSRKPVEG 283
                           79****************************************985 PP
2QLQ52.51.5e-18181216237
                   QLQ   2 aFTaaQlqlLksQilAyKyLaanqPvPpeLlqaiqk 37 
                           +FT++Q+ +L++Q+l+yKy+ +n+ vP++Ll++++k
  HL.SW.v1.0.G005686.1 181 PFTPSQWIELEHQALIYKYITSNVAVPSNLLMPLKK 216
                           9********************************986 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM009513.6E-10180216IPR014978Glutamine-Leucine-Glutamine, QLQ
PfamPF088807.8E-13181214IPR014978Glutamine-Leucine-Glutamine, QLQ
PROSITE profilePS5166621.286181216IPR014978Glutamine-Leucine-Glutamine, QLQ
PROSITE profilePS5166725.287239283IPR014977WRC domain
PfamPF088798.0E-21240282IPR014977WRC domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009624Biological Processresponse to nematode
GO:0048364Biological Processroot development
GO:0048366Biological Processleaf development
GO:0061062Biological Processregulation of nematode larval development
GO:0005634Cellular Componentnucleus
GO:0005524Molecular FunctionATP binding
Sequence ? help Back to Top
Protein Sequence    Length: 622 aa     Download sequence    Send to blast
MDFGLVSLES LVGPPHHERG GGNGGGGGGG GGGGGGGGGV SSQFNDSETK SINNGVLGSG  60
FVKQERSGPC DDDWKSSKVA KTVDLSSSKT MPLHQGTPML RSNSLGFHAD TRQQEHMLSF  120
SSNKSQVSFL SKDAALMERT SQNSAFPYYQ RPPTSYSRNT GYGSGSLNAS MHATFTGIRA  180
PFTPSQWIEL EHQALIYKYI TSNVAVPSNL LMPLKKSLNP YGLAVGWGSF HLGFADNTDP  240
EPGRCRRTDG KKWRCSRDAV ADQKYCERHI NRGRHRSRKP VEGQTGQAAS GTTNSKAAQM  300
TTSVSTSAMP GGGGGGSASN NLAITQHQFK GLQSGAAATN PSTDTLVNRM QDLRGAQSVM  360
SSSNVNTKSN QSTFNVLKQE IPPGASSQSE FGLVSTDSLL NPSQENAYIN SKNYASFLDF  420
SGQEAQDQHH PLRHFIDDWP KDQSNRSVIT WPEEIKSDWT QLSMSIPVTS SEFSSSTNSP  480
TRQEKMALSP LRLSREFEPM QMNLGVNNDL SEATHKLTNW VPKSWGSSMG GPLGEVLTNT  540
AGSVQACKNP SSLNLLTEGW DGSPQLGSSP TGVLQKSTFC SLSNSSSGSS PRADNKRNID  600
GASVFDDVLG STLASSSVPS L*
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that plays a role in the regulation of cell expansion in leaf and cotyledons tissues. Component of a network formed by miR396, the GRFs and their interacting factors (GIFs) acting in the regulation of meristem function, at least partially through the control of cell proliferation. microRNA396-GRF1/GRF3 regulatory module acts as a developmental regulator in the reprogramming of root cells during cyst nematode infection, leading to the formation of the syncytium. {ECO:0000269|PubMed:12974814, ECO:0000269|PubMed:15326298, ECO:0000269|PubMed:22419826, ECO:0000269|PubMed:22751317}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: microRNA 396 (miR396a or miR396b) negatively regulates growth-regulating factors (GRF1-4 and GRF7-9). Up-regulated in response to cyst nematode infection. {ECO:0000269|PubMed:15200956, ECO:0000269|PubMed:19453503, ECO:0000269|PubMed:20023165, ECO:0000269|PubMed:22419826}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAM4886161e-46AM488616.1 Vitis vinifera contig VV78X030262.6, whole genome shotgun sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_015890409.10.0growth-regulating factor 1 isoform X2
SwissprotO810011e-124GRF1_ARATH; Growth-regulating factor 1
TrEMBLA0A2P5FSC70.0A0A2P5FSC7_TREOI; Growth-regulating factor
STRINGXP_010106901.10.0(Morus notabilis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF20853481
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G22840.11e-120growth-regulating factor 1
Publications ? help Back to Top
  1. Casadevall R,Rodriguez RE,Debernardi JM,Palatnik JF,Casati P
    Repression of growth regulating factors by the microRNA396 inhibits cell proliferation by UV-B radiation in Arabidopsis leaves.
    Plant Cell, 2013. 25(9): p. 3570-83
    [PMID:24076976]
  2. Liu J,Rice JH,Chen N,Baum TJ,Hewezi T
    Synchronization of developmental processes and defense signaling by growth regulating transcription factors.
    PLoS ONE, 2014. 9(5): p. e98477
    [PMID:24875638]
  3. Cao Y,Han Y,Jin Q,Lin Y,Cai Y
    Comparative Genomic Analysis of the GRF Genes in Chinese Pear (Pyrus bretschneideri Rehd), Poplar (Populous), Grape (Vitis vinifera), Arabidopsis and Rice (Oryza sativa).
    Front Plant Sci, 2016. 7: p. 1750
    [PMID:27933074]