PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID HL.SW.v1.0.G004269.1
Organism
Humulus lupulus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Cannabaceae; Humulus
Family HD-ZIP
Protein Properties Length: 847aa    MW: 92375.2 Da    PI: 6.2426
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
HL.SW.v1.0.G004269.1genomeHOPBASEView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox57.81.9e-182583357
                          --SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHC....TS-HHHHHHHHHHHHHHHHC CS
              Homeobox  3 kRttftkeqleeLeelFeknrypsaeereeLAkkl....gLterqVkvWFqNrRakekk 57
                          k  ++t+eq+e+Le++++++++ps  +r++L +++    +++ +q+kvWFqNrR +ek+
  HL.SW.v1.0.G004269.1 25 KYVRYTAEQVEALERVYAECPKPSSMRRQQLIRECpilsNIEPKQIKVWFQNRRCREKQ 83
                          5679*****************************************************97 PP
2START154.77.6e-491663732204
                           HHHHHHHHHHHHHHHC-TT-EEEEEXCCTTEEEEEEESSS.SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT-SEEEEEEEECTT.. CS
                 START   2 laeeaaqelvkkalaeepgWvkssesengdevlqkfeeskvdsgealrasgvvdmvlallveellddkeqWdetlakaetlevissg.. 88 
                           +aee+++e+++ka+ ++  Wv+++ +++g++++ +f+ s+++sg a+ra+g+v  +++   +e+l+d+  W +++++ e+      g  
  HL.SW.v1.0.G004269.1 166 IAEETLAEFLSKATGTAVDWVQMPGMKPGPDSVGIFAISQGCSGVAARACGLVSLEPT-KIAEILKDRTSWFRDCRSLEVFTMFPAGng 253
                           7899******************************************************.7777777777***********999999999 PP

                           EEEEEEEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--....-TTSEE-EESSEEEEEEEECTCEEEEEEEE-EE-- CS
                 START  89 galqlmvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppe...sssvvRaellpSgiliepksnghskvtwvehvdlk 173
                           g+++l +++++a+++l+p Rdf+++Ry+  l+ g++v++++S++     p     +++vRae+lpSg+li+p+++g+s +++v+h+ l+
  HL.SW.v1.0.G004269.1 254 GTIELVYTQTYAPTTLAPaRDFWTLRYTTNLENGSLVVCERSLSGSGAGPDsasPAQFVRAEMLPSGYLIRPCEGGGSIIHIVDHMKLE 342
                           ********************************************9888887676679******************************** PP

                           SSXXHHHHHHHHHHHHHHHHHHHHHHTXXXX CS
                 START 174 grlphwllrslvksglaegaktwvatlqrqc 204
                           +++++++lr+l++s+ + ++k + a+l++ +
  HL.SW.v1.0.G004269.1 343 AWSVPEVLRPLYESSKVVAQKVTIAALRYIR 373
                           *************************999865 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5007115.4352084IPR001356Homeobox domain
SMARTSM003891.5E-152288IPR001356Homeobox domain
SuperFamilySSF466891.54E-162387IPR009057Homeodomain-like
CDDcd000862.16E-162585No hitNo description
PfamPF000465.1E-162683IPR001356Homeobox domain
Gene3DG3DSA:1.10.10.602.9E-182783IPR009057Homeodomain-like
CDDcd146862.37E-677116No hitNo description
PROSITE profilePS5084827.054156384IPR002913START domain
CDDcd088756.85E-72160376No hitNo description
SuperFamilySSF559618.24E-34165377No hitNo description
SMARTSM002342.1E-38165375IPR002913START domain
Gene3DG3DSA:3.30.530.203.2E-19165348IPR023393START-like domain
PfamPF018521.4E-46166373IPR002913START domain
PfamPF086707.2E-47701845IPR013978MEKHLA
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0009855Biological Processdetermination of bilateral symmetry
GO:0009944Biological Processpolarity specification of adaxial/abaxial axis
GO:0009956Biological Processradial pattern formation
GO:0010014Biological Processmeristem initiation
GO:0010051Biological Processxylem and phloem pattern formation
GO:0010089Biological Processxylem development
GO:0030154Biological Processcell differentiation
GO:0005634Cellular Componentnucleus
GO:0008289Molecular Functionlipid binding
GO:0044212Molecular Functiontranscription regulatory region DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 847 aa     Download sequence    Send to blast
MAMAVVQHRE SSSGSSINKH LDNGKYVRYT AEQVEALERV YAECPKPSSM RRQQLIRECP  60
ILSNIEPKQI KVWFQNRRCR EKQRKEASRL QTVNRKLSAM NKLLMEENDR LQKQVSQLVC  120
ENGYMRQQLH TVSASAATTD ASCDSVATTP QHSLRDANNP AGLLSIAEET LAEFLSKATG  180
TAVDWVQMPG MKPGPDSVGI FAISQGCSGV AARACGLVSL EPTKIAEILK DRTSWFRDCR  240
SLEVFTMFPA GNGGTIELVY TQTYAPTTLA PARDFWTLRY TTNLENGSLV VCERSLSGSG  300
AGPDSASPAQ FVRAEMLPSG YLIRPCEGGG SIIHIVDHMK LEAWSVPEVL RPLYESSKVV  360
AQKVTIAALR YIRQIAQETS GEVVYSLGRQ PAVLRTFSQR LIRGFNDAVN GFNDDGWSIV  420
TVDSAEDVTI AVNSAKNLST VANPANSLAF LGGVLCAKAS MLLQNVPPAV LVRFLREHRS  480
EWADFNVDGY TAAALKAGSY AYPGMRPTRF TGSQIIMPLG HTIEHEELLE VVRLEGHSLA  540
QEDAFLSRDI HLLQICSGVA DNAVGACSEL VFAPIDEMFP DDAPLLPSGF RIIPLESKAS  600
DSKDALPAHR TLDLTSSLEV GSATNLAAGD LSSCHNARSL LTIAFQFPFE SSLQDNVATM  660
ARQYVRSVIS SVQRVAMAIS PSGVSPGIGP KLSQGSPEAL TLANWICQSY SYYMGSELVR  720
SDNLGGDSIL KNLWHHQDAI LCCSLKSLPV FIFANQAGLD MLETTLVALQ DITLDKIFDE  780
SGRKTLFTDF AKLMQEGFGC LPSGICMSTM GRHVSFDQAV AWKVHASEDI NNVHCLAFSF  840
VNWSFV*
Functional Description ? help Back to Top
Source Description
UniProtProbable transcription factor involved in the regulation of interfascicular fiber (cortical cells) and secondary xylem differentiation in the inflorescence stems. Required for lateral shoot meristems (LSMs) and flower meristems (FMs) initiation. May be involved in the determination of vascular patterning and organ polarity (PubMed:10559440, PubMed:11169198, PubMed:11402186, PubMed:15111711, PubMed:15598805, PubMed:7555701). Directly regulates the expression of AGO10, ZPR1, ZPR2, ZPR3 and ZPR4 (PubMed:22781836). Required to regulate adaxial-abaxial polarity and leaf axial patterning (PubMed:20807212). {ECO:0000269|PubMed:10559440, ECO:0000269|PubMed:11169198, ECO:0000269|PubMed:11402186, ECO:0000269|PubMed:15111711, ECO:0000269|PubMed:15598805, ECO:0000269|PubMed:20807212, ECO:0000269|PubMed:22781836, ECO:0000269|PubMed:7555701}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By auxin. Repressed by ZPR and miR165. Induced by DOF5.1 (PubMed:20807212). {ECO:0000269|PubMed:15111711, ECO:0000269|PubMed:17237362, ECO:0000269|PubMed:20807212}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_021830853.10.0homeobox-leucine zipper protein REVOLUTA
SwissprotQ9SE430.0REV_ARATH; Homeobox-leucine zipper protein REVOLUTA
TrEMBLA0A2P5FTV80.0A0A2P5FTV8_TREOI; Octamer-binding transcription factor
STRINGXP_008225704.10.0(Prunus mume)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF66333147
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G60690.10.0HD-ZIP family protein
Publications ? help Back to Top
  1. Lian H,Li X,Liu Z,He Y
    HYL1 is required for establishment of stamen architecture with four microsporangia in Arabidopsis.
    J. Exp. Bot., 2013. 64(11): p. 3397-410
    [PMID:23918970]
  2. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  3. Baima S, et al.
    Negative feedback regulation of auxin signaling by ATHB8/ACL5-BUD2 transcription module.
    Mol Plant, 2014. 7(6): p. 1006-1025
    [PMID:24777988]
  4. Jia X, et al.
    Functional plasticity of miR165/166 in plant development revealed by small tandem target mimic.
    Plant Sci., 2015. 233: p. 11-21
    [PMID:25711809]
  5. Roodbarkelari F,Du F,Truernit E,Laux T
    ZLL/AGO10 maintains shoot meristem stem cells during Arabidopsis embryogenesis by down-regulating ARF2-mediated auxin response.
    BMC Biol., 2015. 13: p. 74
    [PMID:26358077]
  6. Shi B, et al.
    Two-Step Regulation of a Meristematic Cell Population Acting in Shoot Branching in Arabidopsis.
    PLoS Genet., 2016. 12(7): p. e1006168
    [PMID:27398935]