PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Gorai.009G242400.2
Common NameB456_009G242400
Organism
Gossypium raimondii
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium
Family C2H2
Protein Properties Length: 439aa    MW: 50766.9 Da    PI: 7.1975
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Gorai.009G242400.2genomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H211.90.00067196218123
                         EEETTTTEEESSHHHHHHHHHHT CS
             zf-C2H2   1 ykCpdCgksFsrksnLkrHirtH 23 
                         y C+ C    +rk++L+rH+r++
  Gorai.009G242400.2 196 YFCEFCLNFMKRKEQLQRHMRKC 218
                         78*******************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF541608.33E-2447163IPR016197Chromo domain-like
Gene3DG3DSA:2.30.30.2703.3E-3752123No hitNo description
PfamPF117174.5E-2153111IPR025995RNA binding activity-knot of a chromodomain
CDDcd000241.97E-666112No hitNo description
SMARTSM002981.7E-667126IPR000953Chromo/chromo shadow domain
Gene3DG3DSA:2.30.30.2703.3E-37157207No hitNo description
PROSITE profilePS5172675.469162433IPR002717Histone acetyltransferase domain, MYST-type
SuperFamilySSF557292.24E-111163434IPR016181Acyl-CoA N-acyltransferase
Gene3DG3DSA:3.40.630.304.1E-73221364IPR016181Acyl-CoA N-acyltransferase
PfamPF018533.0E-84223400IPR002717Histone acetyltransferase domain, MYST-type
CDDcd043010.00166274332No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006281Biological ProcessDNA repair
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0010224Biological Processresponse to UV-B
GO:0016573Biological Processhistone acetylation
GO:2000028Biological Processregulation of photoperiodism, flowering
GO:0005634Cellular Componentnucleus
GO:0043995Molecular Functionhistone acetyltransferase activity (H4-K5 specific)
Sequence ? help Back to Top
Protein Sequence    Length: 439 aa     Download sequence    Send to blast
MGSIDTPTIT ENGSTQSHAA AAPADDNQRP LASSNGAPES EATKKRRSGI LPLEVGTRVM  60
CRWRDGKYHP VKVIERRKLQ STEPSDYEYY VHYTEFNRRL DEWVKLEQLD LDSVETVVDE  120
KVEDKVASLK MTRHQKRKID ETHVEGHEEL DAASLREHEE FTKVKNIATI ELGRYEIETW  180
YFSPFPPEYN DSLKLYFCEF CLNFMKRKEQ LQRHMRKCDL KHPPGDEIYR SGTLSMFEVD  240
GKKNKVYGQN LCYLAKLFLD HKTLYYDVDL FLFYVLCECD DRGCHMVGYF SKEKHSEESY  300
NLACILTLPP YQRKGYGKFL IAFSYELSKK EGKVGTPERP LSDLGLLSYR GYWTRVLLDI  360
LKKHKGNISI KELSDMTAIK AEDILTTLQS LELIQYRKGQ HVICADPKVL DRHLKAAGRG  420
GLEVDVSKLI WTPYKEQS*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4dnc_A1e-1181584371282Histone acetyltransferase KAT8
4dnc_B1e-1181584371282Histone acetyltransferase KAT8
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in cotyledons, leaves, stems, roots and, at higher levels in developing flowers, particularly in the anthers and gynoecia (PubMed:19040736). Constitutively expressed in all tissues, predominantly in shoot apical meristem (PubMed:23273925). {ECO:0000269|PubMed:19040736, ECO:0000269|PubMed:23273925}.
Functional Description ? help Back to Top
Source Description
UniProtHistone acetyltransferase which may be involved in transcriptional activation. Acetylates 'Lys-5' of histone H4 (H4K5ac) (PubMed:17877703, PubMed:19040736, PubMed:22170978, PubMed:23273925). Essential for gametophyte development (PubMed:19040736). Involved in DNA repair after UV-B exposure (PubMed:22170978). Negative regulator of flowering controlling the H4K5ac levels in the FLC chromatin (PubMed:23273925). {ECO:0000269|PubMed:17877703, ECO:0000269|PubMed:19040736, ECO:0000269|PubMed:22170978, ECO:0000269|PubMed:23273925}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated upon UV-B exposure. {ECO:0000269|PubMed:22170978}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_016687063.10.0PREDICTED: histone acetyltransferase of the MYST family 1 isoform X2
SwissprotQ9FLF70.0MYST1_ARATH; Histone acetyltransferase of the MYST family 1
TrEMBLA0A0D2UT380.0A0A0D2UT38_GOSRA; Histone acetyltransferase
STRINGGorai.009G242400.10.0(Gossypium raimondii)
Publications ? help Back to Top
  1. Latrasse D, et al.
    The MYST histone acetyltransferases are essential for gametophyte development in Arabidopsis.
    BMC Plant Biol., 2008. 8: p. 121
    [PMID:19040736]
  2. Campi M,D'Andrea L,Emiliani J,Casati P
    Participation of chromatin-remodeling proteins in the repair of ultraviolet-B-damaged DNA.
    Plant Physiol., 2012. 158(2): p. 981-95
    [PMID:22170978]
  3. Paterson AH, et al.
    Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.
    Nature, 2012. 492(7429): p. 423-7
    [PMID:23257886]
  4. Bari A,Orazova S,Ivashchenko A
    miR156- and miR171-binding sites in the protein-coding sequences of several plant genes.
    Biomed Res Int, 2013. 2013: p. 307145
    [PMID:23936788]
  5. Xu Y, et al.
    Arabidopsis MRG domain proteins bridge two histone modifications to elevate expression of flowering genes.
    Nucleic Acids Res., 2014. 42(17): p. 10960-74
    [PMID:25183522]
  6. Raevsky AV,Sharifi M,Samofalova DA,Karpov PA,Blume YB
    3D structure prediction of histone acetyltransferase proteins of the MYST family and their interactome in Arabidopsis thaliana.
    J Mol Model, 2016. 22(11): p. 256
    [PMID:27709438]
  7. Fina JP,Masotti F,Rius SP,Crevacuore F,Casati P
    HAC1 and HAF1 Histone Acetyltransferases Have Different Roles in UV-B Responses in Arabidopsis.
    Front Plant Sci, 2017. 8: p. 1179
    [PMID:28740501]