PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Gh_Sca005145G01
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium
Family E2F/DP
Protein Properties Length: 480aa    MW: 53023.4 Da    PI: 4.7046
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Gh_Sca005145G01genomeNAU-NBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.22.4e-27157222171
          E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                      r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  Gh_Sca005145G01 157 RYDSSLGLLTKKFVNLMKHAEDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKFKNRIQWKG 222
                      6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.6E-29154223IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467855.03E-17157220IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013728.8E-35157222IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.8E-24159222IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440743.4E-31235340No hitNo description
CDDcd146602.48E-47235340No hitNo description
PfamPF164211.5E-31239338IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 480 aa     Download sequence    Send to blast
MSGGAGASDG PTLPYQPSPT ASTAPASTVP SVVPPIRRHL AFASTKPPFV HPDDYHRFSS  60
SNSRGIVADQ EVEAIVVRFP QLKRKSAADK NEVESSQWTS SPGVTSISNS PFQTPVSAKG  120
GRIDNRSKTS KANKSMPQTP VSNAGCPSPL TPAGSCRYDS SLGLLTKKFV NLMKHAEDGI  180
LDLNKAAETL EVQKRRIYDI TNVLEGIGLI EKKFKNRIQW KGVGASKPGE TDGDVSVIQE  240
EIENLSMEER RLDDQIRLEM QERLRDLSEN ENNQKLLFVT EEDIKGIPCF QNETLIAIKA  300
PHGTTLEVPD PDEDVDYRQR RYRIILRSTM GPIDVYLVSQ FEEKFEEMNG VEPPLRVPLA  360
SSSGSNENQV ELVNTVSIQK EIELQAQQTH QICSDINATQ ESVGGMMRIV PSDIDNDADY  420
WLLSDADVSI TDMWKTDCVE WSGVDMLHSD FGMAEVGTPR PESPPSRMTE VPSSDFKSTR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A2e-25152224275PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant in early S phase. Decreased expression during the passage into G2. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543}.
UniprotTISSUE SPECIFICITY: Highly expressed in the shoot apical meristem, emerging leaf primordia, and vascular tissues of young leaf primordia. Expressed in flowers, in epidermis and cortex of hypocotyls, and at lower levels in leaves. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11889041}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_012435055.10.0PREDICTED: transcription factor E2FA-like
SwissprotQ9FNY01e-175E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A0D2SQG10.0A0A0D2SQG1_GOSRA; Uncharacterized protein
STRINGGorai.007G366600.10.0(Gossypium raimondii)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-177E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]