PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Gh_D13G2317
Organism
Gossypium hirsutum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium
Family E2F/DP
Protein Properties Length: 434aa    MW: 48348.6 Da    PI: 4.6205
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Gh_D13G2317genomeNAU-NBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP81.29.1e-26104169171
      E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                  r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiY i+NVLe+++liekk kn+i+wkg
  Gh_D13G2317 104 RYDSSLGLLTKKFINLIKQAEDGILDLNKAASTL---EV--QKRRIYNITNVLEGIGLIEKKLKNRIQWKG 169
                  6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.108.4E-28102171IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.7E-31104169IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467854.53E-16104167IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023193.9E-23106169IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440741.49E-19182296No hitNo description
PfamPF164211.2E-20185295IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 434 aa     Download sequence    Send to blast
MSGSQAADQL LKQSLQQQQQ NQQSLNRQLL FSMAPGDDCH RFALAEPRSI ADQEAEAMVV  60
KSPLKRKSDV ADREVESGSK FGPQTPPSNL GSPGNNLTPA GPCRYDSSLG LLTKKFINLI  120
KQAEDGILDL NKAASTLEVQ KRRIYNITNV LEGIGLIEKK LKNRIQWKGL DVSRPGEVDE  180
NVATLQAEVE NLHNQRLRFI NRLDAQIRLK QLRLLFCMIS EAQLNFIFPR LRWLFVTKED  240
IKSLPCFQNE MLIAVKAPHG TTLEVPDPDE DDDSLQRRYR IVLRSSMGPI DDYLVGEIEE  300
KFEEIQGVGL PSNLPSTSGL DENPAASMVT EESREVETQG QYINGMCLDH HVSQDFVSGI  360
MKIVPSDLDN DADYWLLSDP SVSITDIWRT ESGIELNNFD TLQYTGMAAG STTQPQTPPL  420
NAAEVLPPGN STSR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A1e-2599170274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant at the G1/S transition. Lower but constant level in the following phases. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:16514015}.
UniprotTISSUE SPECIFICITY: Expressed in proliferating cells and several differentiated tissues. Detected in inflorescence and shoot apical meristems, cotyledonary vascular tissues, leaf primordia, young leaves, base of trichomes, central cylinder and elongation zone of roots, lateral root primordia, flowers, pistils of immature flowers and pollen grains. {ECO:0000269|PubMed:16514015}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankJX6155775e-98JX615577.1 Gossypium hirsutum clone NBRI_GE59622 microsatellite sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_012462323.10.0PREDICTED: transcription factor E2FB-like isoform X6
SwissprotQ9FV711e-126E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A2P5QET70.0A0A2P5QET7_GOSBA; Uncharacterized protein
STRINGGorai.013G257100.10.0(Gossypium raimondii)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.21e-128E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]