PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium

Family

HSF

Protein Properties

Length: 474aa MW: 51757.4 Da PI: 4.6093

Description

HSF family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Gh_D11G0302	genome	NAU-NBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HSF_DNA-bind	115.1	4.4e-36	46	138	2	103
HHHHHHHHHCTGGGTTTSEESSSSSEEEES-HHHHHHHTHHHHSTT--HHHHHHHHHHTTEEE---SSBTTTTXTTSEEEEESXXXXXXXXXXXXXX CS HSF_DNA-bind 2 FlkklyeiledeelkeliswsengnsfvvldeeefakkvLpkyFkhsnfaSFvRQLnmYgFkkvkdeekkskskekiweFkhksFkkgkkellekik 98 Fl+k+y++++d++++ ++sws+ +nsf+v+++ efa++vLpkyFkh+nf+SFvRQLn+YgF+kv++++ weF+++ F +g+k+ll +i Gh_D11G0302 46 FLSKTYDMVDDPATDAVVSWSSANNSFIVWNPPEFARDVLPKYFKHNNFSSFVRQLNTYGFRKVDSDR---------WEFANEGFLRGQKDLLLNIS 133 9**************************************************************999.........****************** PP XXXXX CS HSF_DNA-bind 99 rkkse 103 r+k + Gh_D11G0302 134 RRKPA 138 *9865 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	1.2E-39	38	129	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	4.08E-35	41	135	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM00415	7.6E-61	42	135	IPR000232	Heat shock factor (HSF)-type, DNA-binding
PRINTS	PR00056	6.3E-20	46	69	IPR000232	Heat shock factor (HSF)-type, DNA-binding
Pfam	PF00447	4.0E-32	46	135	IPR000232	Heat shock factor (HSF)-type, DNA-binding
PRINTS	PR00056	6.3E-20	84	96	IPR000232	Heat shock factor (HSF)-type, DNA-binding
PROSITE pattern	PS00434	0	85	109	IPR000232	Heat shock factor (HSF)-type, DNA-binding
PRINTS	PR00056	6.3E-20	97	109	IPR000232	Heat shock factor (HSF)-type, DNA-binding

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0043565	Molecular Function	sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 474 aa Download sequence Send to blast
MDGVNSSSNI QKDDASTSTG GAQTAAQPQP KPKPVVVQSA NAPPPFLSKT YDMVDDPATD 60 AVVSWSSANN SFIVWNPPEF ARDVLPKYFK HNNFSSFVRQ LNTYGFRKVD SDRWEFANEG 120 FLRGQKDLLL NISRRKPAQG HGHQQAQQAH GQSSAGGACV EVGEFGLEEE VERLKRDKNV 180 LMQELVRLRQ QQQSTDNQMQ TMAQRLHGME QWQLQMMSFL AKAVQSPGFL AQFMQQKNES 240 NRHITEANKK RRLKQDGIVG NEHSAASDGQ IVKYQPLTND AKAMLRQIVK GDTSTRLDSI 300 NNYHDNFLVG DGLSSSTGLD GGKSSSHASG VTLQEVPPTS GISVDRPSSA ISEIQSSPCT 360 TSSEKITTTQ STNSSALVGG EKVPSISIPQ TNTIMPELSQ IPEMVPESDV DCMESETGNG 420 GFIDPICLVP LELDDIAPDP DIDALLDSSS FWDDLIVQGP VPEDIESISM DDKS

Sequence ? help Back to Top

Protein Sequence Length: 474 aa Download sequence Send to blast

MDGVNSSSNI QKDDASTSTG GAQTAAQPQP KPKPVVVQSA NAPPPFLSKT YDMVDDPATD  60
AVVSWSSANN SFIVWNPPEF ARDVLPKYFK HNNFSSFVRQ LNTYGFRKVD SDRWEFANEG  120
FLRGQKDLLL NISRRKPAQG HGHQQAQQAH GQSSAGGACV EVGEFGLEEE VERLKRDKNV  180
LMQELVRLRQ QQQSTDNQMQ TMAQRLHGME QWQLQMMSFL AKAVQSPGFL AQFMQQKNES  240
NRHITEANKK RRLKQDGIVG NEHSAASDGQ IVKYQPLTND AKAMLRQIVK GDTSTRLDSI  300
NNYHDNFLVG DGLSSSTGLD GGKSSSHASG VTLQEVPPTS GISVDRPSSA ISEIQSSPCT  360
TSSEKITTTQ STNSSALVGG EKVPSISIPQ TNTIMPELSQ IPEMVPESDV DCMESETGNG  420
GFIDPICLVP LELDDIAPDP DIDALLDSSS FWDDLIVQGP VPEDIESISM DDKS

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5d5u_B	5e-28	44	135	27	129	Heat shock factor protein 1
5d5v_B	5e-28	44	135	27	129	Heat shock factor protein 1
5d5v_D	5e-28	44	135	27	129	Heat shock factor protein 1
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Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	247	254	NKKRRLKQ
2	248	253	KKRRLK

Functional Description ? help Back to Top
Source	Description
UniProt	DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. {ECO:0000250}.

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	KR067402	0.0	KR067402.1 Gossypium hirsutum HSF21 mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_016695732.1	0.0	PREDICTED: heat shock factor protein HSF8-like
Swissprot	Q40152	1e-156	HSF8_SOLLC; Heat shock factor protein HSF8
TrEMBL	A0A1U8JZM9	0.0	A0A1U8JZM9_GOSHI; heat shock factor protein HSF8-like
STRING	Gorai.007G033300.1	0.0	(Gossypium raimondii)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM6470	24	40

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G32330.1	1e-104	heat shock transcription factor A1D

Publications ? help Back to Top
Zhu B, et al. Identification and characterization of a novel heat shock transcription factor gene, GmHsfA1, in soybeans (Glycine max). J. Plant Res., 2006. 119(3): p. 247-56 [PMID:16570125] Cai SY, et al. HsfA1a upregulates melatonin biosynthesis to confer cadmium tolerance in tomato plants. J. Pineal Res., 2017. [PMID:28095626] Zhou J, et al. Heat Shock Factor HsfA1a Is Essential for R Gene-Mediated Nematode Resistance and Triggers H2O2 Production1. Plant Physiol., 2018. 176(3): p. 2456-2471 [PMID:29339397]