PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Gh_A12G2462
Common NameHOX3
Organism
Gossypium hirsutum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium
Family HD-ZIP
Protein Properties Length: 713aa    MW: 78296.8 Da    PI: 6.6691
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Gh_A12G2462genomeNAU-NBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox65.66.5e-212883156
                 TT--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS
     Homeobox  1 rrkRttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56
                 +++ +++t++q+++Le++F+++++p++++r +L+++lgL  rq+k+WFqNrR+++k
  Gh_A12G2462 28 KKPYHRHTAHQIQRLESMFKECPHPDEKQRLQLSRELGLAPRQIKFWFQNRRTQMK 83
                 78999************************************************998 PP
2START177.86.3e-562274492206
                  HHHHHHHHHHHHHHHC-TT-EEEE....EXCCTTEEEEEEESSS........SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT-S....EEEEEEE CS
        START   2 laeeaaqelvkkalaeepgWvkss....esengdevlqkfeeskv.......dsgealrasgvvdmvlallveellddkeqWdetla....kaetlev 84 
                  +a  a++el+++ + +ep+W ks     + +n + + ++f++ ++        ++ea+r+sgvv+m+   lv  ++d++ +W e ++     a+t+ev
  Gh_A12G2462 227 IAANAMEELLRLLQTNEPLWIKSTndgkDVLNLESYERIFPKPNNthfkspnIRVEASRDSGVVIMNGLALVDMFMDSN-KWLELFPtivsIAKTIEV 323
                  67889*******************998888888888888887777899***99**************************.******999999****** PP

                  ECTT......EEEEEEEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--.-TTSEE-EESSEEEEEEEECTCEEEEEEEE-EE--SS CS
        START  85 issg......galqlmvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppesssvvRaellpSgiliepksnghskvtwvehvdlkgr 175
                  is+g      g lqlm+ elq+lsplvp R+f+++Ry++q ++g w+iv vS d +q+ ++     R+++lpSg+li++++ng+skvtw+ehv+ +++
  Gh_A12G2462 324 ISPGmlgthsGSLQLMYEELQVLSPLVPtREFYTLRYCQQIEQGLWAIVNVSYDLPQFASQ----CRSHRLPSGCLIQDMPNGYSKVTWLEHVEIEDK 417
                  **********************************************************987....********************************* PP

                  XX.HHHHHHHHHHHHHHHHHHHHHHTXXXXXX CS
        START 176 lp.hwllrslvksglaegaktwvatlqrqcek 206
                  +p h l+r lv+sg a+ga +w+ tlqr ce+
  Gh_A12G2462 418 TPiHRLYRDLVHSGSAFGAERWLTTLQRMCER 449
                  ******************************97 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF466897.52E-211185IPR009057Homeodomain-like
Gene3DG3DSA:1.10.10.607.3E-231379IPR009057Homeodomain-like
PROSITE profilePS5007117.9772585IPR001356Homeobox domain
SMARTSM003892.4E-192789IPR001356Homeobox domain
CDDcd000863.61E-192886No hitNo description
PfamPF000461.5E-182883IPR001356Homeobox domain
PROSITE patternPS0002706083IPR017970Homeobox, conserved site
PROSITE profilePS5084853.15217452IPR002913START domain
SuperFamilySSF559616.04E-39218450No hitNo description
CDDcd088754.65E-122221448No hitNo description
SMARTSM002349.8E-47226449IPR002913START domain
PfamPF018528.7E-49227449IPR002913START domain
Gene3DG3DSA:3.30.530.208.3E-8243262IPR023393START-like domain
Gene3DG3DSA:3.30.530.208.3E-8336431IPR023393START-like domain
SuperFamilySSF559611.04E-22470705No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0008289Molecular Functionlipid binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 713 aa     Download sequence    Send to blast
MDCGSGGGGL GASGSGGDHD SSDLSRRKKP YHRHTAHQIQ RLESMFKECP HPDEKQRLQL  60
SRELGLAPRQ IKFWFQNRRT QMKAQHERAD NSALRAENDK IRCENIAIRE ALKNVICPSC  120
GGPPANEDSY FDDQKMRMEN AQLKEELDRV SSIAAKYIGR PISQLPPVQP VHISSLDFRM  180
ASFDGYGVGA GPSLDLDLLP GSSSSMPNLP FQPVVISDID KSLMSDIAAN AMEELLRLLQ  240
TNEPLWIKST NDGKDVLNLE SYERIFPKPN NTHFKSPNIR VEASRDSGVV IMNGLALVDM  300
FMDSNKWLEL FPTIVSIAKT IEVISPGMLG THSGSLQLMY EELQVLSPLV PTREFYTLRY  360
CQQIEQGLWA IVNVSYDLPQ FASQCRSHRL PSGCLIQDMP NGYSKVTWLE HVEIEDKTPI  420
HRLYRDLVHS GSAFGAERWL TTLQRMCERF ACLMVSSTST RDLGGVIPSP DGKRSMMKLA  480
QRMVNNFCTS VGTSNSHRST TLSGSNEIGV RVTVHKSSDP GQPNGIVLSA ATTFWLPVSP  540
QNVFNFFKDE RTRPQWDVLS NGNAVQEVAH IANGSHPGNC ISVLRAFNTS HNNMLILQES  600
CIDSSGSLVV YCPVDLPAIN VAMSGEDPSY IPLLPSGFTI TPDGHLEQGD GASTSSSTGH  660
GRSSGGSLIT VAFQILVSSL PSAKLNLDSV TIVNNLIANT VQQIKAALNC PSS
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Ghi.164600.0boll| ovule
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO518722860.0
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: During embryo development, expressed in all cells at the 4- and 16-cell embryo stages. Expression is restricted to the protoderm from the globular stage onward. {ECO:0000269|PubMed:25564655}.
UniprotTISSUE SPECIFICITY: Expressed in apical meristems and young epidermal tissue including trichomes and stipules. Expressed in lateral root tips, the L1 layer of apical inflorescence meristems and early flower primordia, carpel and petal epidermis, stigma papillae, ovule primordia, nucellus and embryo. {ECO:0000269|PubMed:16778018}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor which acts as positive regulator of drought stress tolerance. Can transactivate CIPK3, NCED3 and ERECTA (PubMed:18451323). Transactivates several cell-wall-loosening protein genes by directly binding to HD motifs in their promoters. These target genes play important roles in coordinating cell-wall extensibility with root development and growth (PubMed:24821957). Transactivates CYP74A/AOS, AOC3, OPR3 and 4CLL5/OPCL1 genes by directly binding to HD motifs in their promoters. These target genes are involved in jasmonate (JA) biosynthesis, and JA signaling affects root architecture by activating auxin signaling, which promotes lateral root formation (PubMed:25752924). Acts as negative regulator of trichome branching (PubMed:16778018, PubMed:24824485). Required for the establishment of giant cell identity on the abaxial side of sepals (PubMed:23095885). May regulate cell differentiation and proliferation during root and shoot meristem development (PubMed:25564655). {ECO:0000269|PubMed:16778018, ECO:0000269|PubMed:18451323, ECO:0000269|PubMed:23095885, ECO:0000269|PubMed:24821957, ECO:0000269|PubMed:24824485, ECO:0000269|PubMed:25564655, ECO:0000269|PubMed:25752924}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankKJ5958470.0KJ595847.1 Gossypium hirsutum homeodomain protein HOX3-A (HOX3) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_016686699.10.0PREDICTED: homeobox-leucine zipper protein HDG11-like
RefseqXP_016686701.10.0PREDICTED: homeobox-leucine zipper protein HDG11-like
SwissprotQ9FX310.0HDG11_ARATH; Homeobox-leucine zipper protein HDG11
TrEMBLA0A1U8JEJ50.0A0A1U8JEJ5_GOSHI; homeobox-leucine zipper protein HDG11-like
STRINGGorai.008G293300.10.0(Gossypium raimondii)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM30042665
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G73360.10.0homeodomain GLABROUS 11
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Khosla A, et al.
    HD-Zip Proteins GL2 and HDG11 Have Redundant Functions in Arabidopsis Trichomes, and GL2 Activates a Positive Feedback Loop via MYB23.
    Plant Cell, 2014. 26(5): p. 2184-2200
    [PMID:24824485]
  3. Horstman A, et al.
    AIL and HDG proteins act antagonistically to control cell proliferation.
    Development, 2015. 142(3): p. 454-64
    [PMID:25564655]
  4. Cai XT,Xu P,Wang Y,Xiang CB
    Activated expression of AtEDT1/HDG11 promotes lateral root formation in Arabidopsis mutant edt1 by upregulating jasmonate biosynthesis.
    J Integr Plant Biol, 2015. 57(12): p. 1017-30
    [PMID:25752924]
  5. Yu LH, et al.
    Arabidopsis EDT1/HDG11 improves drought and salt tolerance in cotton and poplar and increases cotton yield in the field.
    Plant Biotechnol. J., 2016. 14(1): p. 72-84
    [PMID:25879154]
  6. Zhu Z, et al.
    Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Drought and Osmotic Stress Tolerance.
    Front Plant Sci, 2016. 7: p. 1285
    [PMID:27625663]
  7. Liu Y, et al.
    Overexpression of AtEDT1 promotes root elongation and affects medicinal secondary metabolite biosynthesis in roots of transgenic Salvia miltiorrhiza.
    Protoplasma, 2017. 254(4): p. 1617-1625
    [PMID:27915455]
  8. Ueda M, et al.
    Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote.
    Genes Dev., 2017. 31(6): p. 617-627
    [PMID:28404632]
  9. Lung SC, et al.
    Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors.
    New Phytol., 2018. 218(1): p. 183-200
    [PMID:29288621]
  10. Zheng G, et al.
    Over-Expression of Arabidopsis EDT1 Gene Confers Drought Tolerance in Alfalfa (Medicago sativa L.).
    Front Plant Sci, 2017. 8: p. 2125
    [PMID:29326737]