PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID GSVIVT01032583001
Common NameLOC100266295, VIT_14s0066g02370
Organism
Vitis vinifera
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; rosids incertae sedis; Vitales; Vitaceae; Vitis
Family E2F/DP
Protein Properties Length: 373aa    MW: 41681.9 Da    PI: 9.2252
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
GSVIVT01032583001genomeGenoscopeView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP73.91.7e-231984171
            E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                       rkeksL+ll+++fl+l+ +++ + + l+++a++L    v  +rRRiYDi+N+Le+++++++k+kn+++wkg
  GSVIVT01032583001 19 RKEKSLGLLCTNFLSLYDREDVESIGLDDAASRL---GV--ERRRIYDIVNILESVGILARKAKNQYSWKG 84
                       79****************9999************...**..****************************98 PP
2E2F_TDP74.89e-24144224171
            E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                        r+eksL+llt++f+kl+ +s+++ ++l+ +a +L+ +      +++k+RR+YDi+NVL+++nliek     ++k+++rw g
  GSVIVT01032583001 144 RREKSLGLLTRNFIKLFLCSDADLISLDCAAMALLGDghnstAMRTKVRRLYDIANVLSSMNLIEKtphpeSRKPAFRWLG 224
                        689*******************************************************************99*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.1E-251785IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467858.84E-161882IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013728.0E-281984IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023193.6E-202084IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.102.5E-21140225IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.3E-28144224IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.3E-18146224IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467854.04E-13146225IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 373 aa     Download sequence    Send to blast
MSSFVSREND PKAQYFYSRK EKSLGLLCTN FLSLYDREDV ESIGLDDAAS RLGVERRRIY  60
DIVNILESVG ILARKAKNQY SWKGFGAIPR ALEELKEEGL RENFSISDCC NFAKSLDDIE  120
EGGSSNSKSD GQDRSSGLSK NDNRREKSLG LLTRNFIKLF LCSDADLISL DCAAMALLGD  180
GHNSTAMRTK VRRLYDIANV LSSMNLIEKT PHPESRKPAF RWLGVKGKLK NASATAMDVQ  240
QPKKRVFGTD VTNYSLKRNK ADSSTDWKSN QNINMPLHMK PDDLENNGDG LEQNSKHSSK  300
GFVFGPFTPA SAPGVGESAN KIMKPTQDWE SLASTFRPQY RNQAISDLFG HYVEAWKSWY  360
VEVAGKKQTN SR*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A9e-36182163228Transcription factor E2F8
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Vvi.128190.0fruit
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant in mid-S phase. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:15308755}.
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Not detected during early S phase. Expressed at both the G1/S and S/G2 transitions, with a peak during G2. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:18787127}.
UniprotTISSUE SPECIFICITY: Expressed exclusively in mitotically dividing cells. Highly expressed in young leaves and mature flowers. Lower expression in young stalk and in young and mature flowers. {ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366}.
UniprotTISSUE SPECIFICITY: High expression in young cotyledons and leaves, hypocotyls, shoot apical meristem, roots and mature pollen grains, moderate in developing trichomes, flowers and at early stages of developing anthers, and barely detectable in mature leaves. Not detected in primary root meristem, emerging lateral roots, pistils, developing embryos and siliques. {ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15308755}.
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Does not bind retinoblastoma-related proteins. Acts as a growth regulator but is not associated with changes in the expression of cell cycle marker genes or in nuclear ploidy levels. Has no effect on cell proliferation, but may repress cell wall biosynthesis genes during cell elongation in differentiated cells. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15308755}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAM4800210.0AM480021.1 Vitis vinifera, whole genome shotgun sequence, contig VV78X264745.8, clone ENTAV 115.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_002281897.10.0PREDICTED: E2F transcription factor-like E2FF isoform X2
SwissprotQ8LSZ41e-116E2FE_ARATH; E2F transcription factor-like E2FE
SwissprotQ8RWL01e-117E2FF_ARATH; E2F transcription factor-like E2FF
TrEMBLD7TWZ40.0D7TWZ4_VITVI; Uncharacterized protein
STRINGVIT_14s0066g02370.t010.0(Vitis vinifera)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP24741634
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G01330.11e-119DP-E2F-like protein 3
Publications ? help Back to Top
  1. Dohmann EM, et al.
    The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability.
    Development, 2008. 135(11): p. 2013-22
    [PMID:18434413]
  2. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  3. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  4. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]