PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID FANhyb_rscf00001184.1.g00001.1
Organism
Fragaria x ananassa
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Rosoideae; Potentilleae; Fragariinae; Fragaria
Family bHLH
Protein Properties Length: 453aa    MW: 50473.2 Da    PI: 5.1914
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
FANhyb_rscf00001184.1.g00001.1genomekazusaView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH37.34.8e-12230281155
                                     CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
                             HLH   1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                                     +r++h ++Er+RR+++N+ +  Lr+l+P +   + ++ + a+i   A++++++L+
  FANhyb_rscf00001184.1.g00001.1 230 QRMTHIAVERNRRKQMNEHLRVLRSLMPGS---YVQRGDQASIIGGAIDFVRELE 281
                                     79****************************...9*****************9995 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000838.46E-14228285No hitNo description
Gene3DG3DSA:4.10.280.102.3E-13228284IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474599.95E-17229303IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088815.529229280IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000102.2E-9230281IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003533.4E-9235286IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0010377Biological Processguard cell fate commitment
GO:0045597Biological Processpositive regulation of cell differentiation
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051782Biological Processnegative regulation of cell division
GO:0005634Cellular Componentnucleus
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 453 aa     Download sequence    Send to blast
MMYVCSTNNY ELLQAAFLPP SFNGLDYTLD HHHDQDQQQL MNSSHVDQTC SSHENNNNGM  60
VNYLLNDHHH DQLQLQHQQP QQTQHPPPAG FGGASSTSFD KLNFADVMQF ADFGPKLALN  120
QTKISEDESG IDPVYFLKFP VLNDNKLDDD EDQSLMVPQQ DGPDSRQEER FTKSGEEEEA  180
RGVSGSTNNS VQLRFLGDDV QNPRGGLPEP PKNKRKRPRS TKTSQEVESQ RMTHIAVERN  240
RRKQMNEHLR VLRSLMPGSY VQRGDQASII GGAIDFVREL EQLLQCLESQ KRRRLLGEAP  300
PPRQVGADSA AAANMAVLPS QPDHQGGGGV PFFPVPNLPL NPNDPNKFVD FETGLREETA  360
ESKSCFADVE VKVLGGDAMI KILSQRRPGQ LIKAIAALED LQLTILHTNI TTIEQTVLYC  420
FKVASESRFT AEDIASSVQQ IFSFIHANTA SGM
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1230241RMTHIAVERNRR
2290294KRRRL
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024195310.10.0transcription factor FAMA
SwissprotQ56YJ81e-138FAMA_ARATH; Transcription factor FAMA
TrEMBLA0A2P6QWJ40.0A0A2P6QWJ4_ROSCH; Putative transcription factor bHLH family
STRINGXP_008224493.10.0(Prunus mume)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF104893340
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G24140.11e-119bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  3. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  4. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  5. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  6. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]