PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

FANhyb_rscf00000916.1.g00005.1

Organism

Fragaria x ananassa

Taxonomic ID

3747

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Rosoideae; Potentilleae; Fragariinae; Fragaria

Family

bHLH

Protein Properties

Length: 458aa MW: 50744.9 Da PI: 8.0813

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
FANhyb_rscf00000916.1.g00005.1	genome	kazusa	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	33.4	8.4e-11	145	187	8	55
HHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS HLH 8 rErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 Er+RR r+++++ Lr+l+P+ +K++Ka+i+ Av Y+++Lq FANhyb_rscf00000916.1.g00005.1 145 SERKRRGRMKEKLYALRSLVPNI-----TKMDKASIVGDAVAYVQDLQ 187 6*******************7.....7****************9 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS50888	15.18	137	186	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd00083	3.60E-12	139	188	No hit	No description
SuperFamily	SSF47459	1.57E-15	139	204	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Gene3D	G3DSA:4.10.280.10	1.9E-15	139	205	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SMART	SM00353	3.8E-14	143	192	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Pfam	PF00010	2.1E-8	145	187	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0034756	Biological Process	regulation of iron ion transport
GO:0071281	Biological Process	cellular response to iron ion
GO:0071369	Biological Process	cellular response to ethylene stimulus
GO:0071732	Biological Process	cellular response to nitric oxide
GO:0046983	Molecular Function	protein dimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 458 aa Download sequence Send to blast
MDGIGASGNN HDIGGHSIIN DFELQDFIDD ANFDQFLDLI RGENEDPAAA HFDCDLLSGS 60 CFVDNQCVQI TPDSGFFGFG HNTTGISDAA PFLTTLPHFD GEMNDIGRDE DNDADSCGTT 120 TTTTTNTTGT TTKKPKVDRS RTLVSERKRR GRMKEKLYAL RSLVPNITKM DKASIVGDAV 180 AYVQDLQKHA KKLEVEISGL EASIEGSGGK QAGTGSMQNS TKNKFVADNY HLTPKGFIQI 240 DVSQVEEKGF YVKVGCNKGV GVATSLYKAI ESLTSFNVLS SNLNTINSRR FEITLILDFR 300 APQLSAFYVG GYHFYRVIRW LWRPHNGSLS TSSVTERAGR QLFRDEVKWS YQDKDGLNQQ 360 RGGEICGRNE KRGGQQRAAR LDPEAIYLAC LKPRPTLKSI SIQTASMQAP FALTWIARPL 420 RFASFSTFQH DSLTAVKVLW VSKNPRHPSI HGFFRNSN

Sequence ? help Back to Top

Protein Sequence Length: 458 aa Download sequence Send to blast

MDGIGASGNN HDIGGHSIIN DFELQDFIDD ANFDQFLDLI RGENEDPAAA HFDCDLLSGS  60
CFVDNQCVQI TPDSGFFGFG HNTTGISDAA PFLTTLPHFD GEMNDIGRDE DNDADSCGTT  120
TTTTTNTTGT TTKKPKVDRS RTLVSERKRR GRMKEKLYAL RSLVPNITKM DKASIVGDAV  180
AYVQDLQKHA KKLEVEISGL EASIEGSGGK QAGTGSMQNS TKNKFVADNY HLTPKGFIQI  240
DVSQVEEKGF YVKVGCNKGV GVATSLYKAI ESLTSFNVLS SNLNTINSRR FEITLILDFR  300
APQLSAFYVG GYHFYRVIRW LWRPHNGSLS TSSVTERAGR QLFRDEVKWS YQDKDGLNQQ  360
RGGEICGRNE KRGGQQRAAR LDPEAIYLAC LKPRPTLKSI SIQTASMQAP FALTWIARPL  420
RFASFSTFQH DSLTAVKVLW VSKNPRHPSI HGFFRNSN

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor. Essential protein involved in iron uptake responses. Regulates FRO2 at the level of mRNA accumulation and IRT1 at the level of protein accumulation. Confers enhanced iron mobilization responses at low iron supply. {ECO:0000269\|PubMed:15539473, ECO:0000269\|PubMed:15556641, ECO:0000269\|PubMed:16117851}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: In roots by iron deficiency. Repressed by cytokinins. Induced by cold, UV, ethylene (ACC), jasmonic acid (JA), flagellin, and salicylic acid (SA) treatments. {ECO:0000269\|PubMed:12679534, ECO:0000269\|PubMed:15531708, ECO:0000269\|PubMed:15539473, ECO:0000269\|PubMed:15556641, ECO:0000269\|PubMed:18397377}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_011470675.1	0.0	PREDICTED: transcription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR-like
Swissprot	Q0V7X4	7e-72	FIT_ARATH; Transcription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR
TrEMBL	A0A2P6QGS3	1e-162	A0A2P6QGS3_ROSCH; Putative transcription factor bHLH family
STRING	XP_004288930.1	0.0	(Fragaria vesca)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF3679	33	58

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G28160.1	8e-70	FER-like regulator of iron uptake

Publications ? help Back to Top
Schmid NB, et al. Feruloyl-CoA 6'-Hydroxylase1-dependent coumarins mediate iron acquisition from alkaline substrates in Arabidopsis. Plant Physiol., 2014. 164(1): p. 160-72 [PMID:24246380] Doustaly F, et al. Uranium perturbs signaling and iron uptake response in Arabidopsis thaliana roots. Metallomics, 2014. 6(4): p. 809-21 [PMID:24549117] Le CT, et al. ZINC FINGER OF ARABIDOPSIS THALIANA12 (ZAT12) Interacts with FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (FIT) Linking Iron Deficiency and Oxidative Stress Responses. Plant Physiol., 2016. 170(1): p. 540-57 [PMID:26556796] Yang L, et al. Carbon Monoxide Interacts with Auxin and Nitric Oxide to Cope with Iron Deficiency in Arabidopsis. Front Plant Sci, 2016. 7: p. 112 [PMID:27014280] Zhou C, et al. Paenibacillus polymyxa BFKC01 enhances plant iron absorption via improved root systems and activated iron acquisition mechanisms. Plant Physiol. Biochem., 2016. 105: p. 162-173 [PMID:27105423] Mai HJ,Pateyron S,Bauer P Iron homeostasis in Arabidopsis thaliana: transcriptomic analyses reveal novel FIT-regulated genes, iron deficiency marker genes and functional gene networks. BMC Plant Biol., 2016. 16(1): p. 211 [PMID:27716045] Zhou C, et al. Exogenous Melatonin Improves Plant Iron Deficiency Tolerance via Increased Accumulation of Polyamine-Mediated Nitric Oxide. Int J Mol Sci, 2017. [PMID:27792144] Ezer D, et al. The G-Box Transcriptional Regulatory Code in Arabidopsis. Plant Physiol., 2017. 175(2): p. 628-640 [PMID:28864470] Naranjo-Arcos MA, et al. Dissection of iron signaling and iron accumulation by overexpression of subgroup Ib bHLH039 protein. Sci Rep, 2017. 7(1): p. 10911 [PMID:28883478] Kailasam S,Wang Y,Lo JC,Chang HF,Yeh KC S-Nitrosoglutathione works downstream of nitric oxide to mediate iron-deficiency signaling in Arabidopsis. Plant J., 2018. 94(1): p. 157-168 [PMID:29396986] Cui Y, et al. Four IVa bHLH Transcription Factors Are Novel Interactors of FIT and Mediate JA Inhibition of Iron Uptake in Arabidopsis. Mol Plant, 2018. 11(9): p. 1166-1183 [PMID:29960107]