PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; BOP clade; Pooideae; Triticodae; Triticeae; Triticinae; Aegilops

Family

E2F/DP

Protein Properties

Length: 281aa MW: 31683.9 Da PI: 5.0291

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
EMT13744	genome	BGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	80.8	1.2e-25	24	89	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r e+sL+ lt+kf++ll+++e+gi++ln+va+ L v k+RRiYDi+NVLe+++l+ekk kn+irw+g EMT13744 24 RAEHSLGELTKKFISLLKQAEDGILDLNNVAEIL---VV--KKRRIYDITNVLEGIGLLEKKLKNRIRWRG 89 6799****************************...88..9*************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	1.9E-27	22	91	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	1.14E-16	24	87	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	1.8E-30	24	89	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	1.5E-23	26	89	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	6.51E-42	99	205	No hit	No description
SuperFamily	SSF144074	8.63E-31	100	205	No hit	No description
Pfam	PF16421	8.5E-30	104	203	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0005667	Cellular Component	transcription factor complex
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 281 aa Download sequence Send to blast
MDCRPLYQML ARSPGTPLTP GSSRAEHSLG ELTKKFISLL KQAEDGILDL NNVAEILVVK 60 KRRIYDITNV LEGIGLLEKK LKNRIRWRGL DDSGANLDNE ISVLETELEN LKLQEKALDN 120 RISEMHEKVR ELTEEENNQR WLYLTEDDIK GLPCFQNETL IAIKAPHGTT LEVPDPDEAG 180 DYIQRRYTIV IRSTMGSIDL YLVSKFEENM EELVGVATPP RHANVAEPAS TDGFIATEAG 240 QSSRSKDKLP NIQHIHRTPD LNAQDFGGMA KITPEFHVRS L

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	6e-24	14	90	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AK372442	0.0	AK372442.1 Hordeum vulgare subsp. vulgare mRNA for predicted protein, complete cds, clone: NIASHv3002B23.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_020167678.1	0.0	transcription factor E2FA-like isoform X1
Refseq	XP_020167679.1	0.0	transcription factor E2FA-like isoform X2
Swissprot	Q9FNY0	4e-89	E2FA_ARATH; Transcription factor E2FA
TrEMBL	N1QWA1	0.0	N1QWA1_AEGTA; Putative Transcription factor E2F5
STRING	EMT13744	0.0	(Aegilops tauschii)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Monocots	OGMP625	37	148

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	3e-85	E2F transcription factor 3

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]