PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; BOP clade; Pooideae; Triticodae; Triticeae; Triticinae; Aegilops

Family

AP2

Protein Properties

Length: 571aa MW: 60534.2 Da PI: 6.6441

Description

AP2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
EMT06985	genome	BGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	AP2	34.4	5.5e-11	194	250	1	55
AP2 1 sgykGVrwdkkrgrWvAeIrd.pseng..kr.krfslgkfgtaeeAakaaiaarkkleg 55 s y+GV++++++gr++A+++d + ++ k + g ++ +++Aa+a++ a++k++g EMT06985 194 SIYRGVTRHRWTGRYEAHLWDnSCR-RegQTrKGKQ-GGYDKEDKAARAYDLAALKYWG 250 57*****************5544.2354448877.6699999***********98 PP
2	AP2	51.8	2.1e-16	293	344	1	55
AP2 1 sgykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 s+y+GV++++++grW A+I + +k +lg+f t+eeAa+a++ a+ k++g EMT06985 293 SKYRGVTRHHQQGRWQARIGRVAG---NKDLYLGTFTTEEEAAEAYDIAAIKFRG 344 89**************988532...5**********************998 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF54171	4.51E-13	194	260	IPR016177	DNA-binding domain
CDD	cd00018	9.28E-15	194	260	No hit	No description
Pfam	PF00847	2.9E-8	194	250	IPR001471	AP2/ERF domain
PROSITE profile	PS51032	16.239	195	258	IPR001471	AP2/ERF domain
SMART	SM00380	2.1E-20	195	264	IPR001471	AP2/ERF domain
Gene3D	G3DSA:3.30.730.10	7.2E-10	195	258	IPR001471	AP2/ERF domain
PRINTS	PR00367	3.9E-6	196	207	IPR001471	AP2/ERF domain
SuperFamily	SSF54171	7.19E-18	293	353	IPR016177	DNA-binding domain
Pfam	PF00847	3.9E-10	293	344	IPR001471	AP2/ERF domain
CDD	cd00018	3.75E-22	293	354	No hit	No description
SMART	SM00380	2.1E-31	294	358	IPR001471	AP2/ERF domain
PROSITE profile	PS51032	19.361	294	352	IPR001471	AP2/ERF domain
Gene3D	G3DSA:3.30.730.10	3.1E-18	294	352	IPR001471	AP2/ERF domain
PRINTS	PR00367	3.9E-6	334	354	IPR001471	AP2/ERF domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 571 aa Download sequence Send to blast
MTGLRACANY GVMDAFNGGT QETQDWAMRG LDYHGGSSEL SMLVGSSGGR MTVDDGEAPK 60 LEDFLGGNSF SDVQDHAGSY LFSSGSAMGS GAASGSHGAQ HDQEMSADAS ATRGACSGAP 120 GSTGNGVGVA SSRGQGLALS MSMGSNSHPQ MPVVPAAVGT ESTSSENKRV DSPSAGTADA 180 VQRKSIDTFG QRTSIYRGVT RHRWTGRYEA HLWDNSCRRE GQTRKGKQGG YDKEDKAARA 240 YDLAALKYWG TTTTTNIPIS TYEKEIEEMK HMTRQEYIAY LRRNSSGFSR GASKYRGVTR 300 HHQQGRWQAR IGRVAGNKDL YLGTFTTEEE AAEAYDIAAI KFRGLNAVTN FDITRYDVDQ 360 IVGGAARRLK EAAELAEAGV WRAEDGSIVS HLQADAMAGY HHGWPTSIAF GSHQQQQSAA 420 QLALHYPYGV GGQARGWCKP EQDAVIAAGH GGQDMQELHL GSGGSTHNFF QPASRTAVYG 480 NGGGGAWYQG LGGNAYMMPV GTVVDADQGH SGSTATTEEG RLVGYGAEAG VDPYAAMRRA 540 YELSQGSSSV SVAKVADGYS NNWSSPFNGM G

Sequence ? help Back to Top

Protein Sequence Length: 571 aa Download sequence Send to blast

MTGLRACANY GVMDAFNGGT QETQDWAMRG LDYHGGSSEL SMLVGSSGGR MTVDDGEAPK  60
LEDFLGGNSF SDVQDHAGSY LFSSGSAMGS GAASGSHGAQ HDQEMSADAS ATRGACSGAP  120
GSTGNGVGVA SSRGQGLALS MSMGSNSHPQ MPVVPAAVGT ESTSSENKRV DSPSAGTADA  180
VQRKSIDTFG QRTSIYRGVT RHRWTGRYEA HLWDNSCRRE GQTRKGKQGG YDKEDKAARA  240
YDLAALKYWG TTTTTNIPIS TYEKEIEEMK HMTRQEYIAY LRRNSSGFSR GASKYRGVTR  300
HHQQGRWQAR IGRVAGNKDL YLGTFTTEEE AAEAYDIAAI KFRGLNAVTN FDITRYDVDQ  360
IVGGAARRLK EAAELAEAGV WRAEDGSIVS HLQADAMAGY HHGWPTSIAF GSHQQQQSAA  420
QLALHYPYGV GGQARGWCKP EQDAVIAAGH GGQDMQELHL GSGGSTHNFF QPASRTAVYG  480
NGGGGAWYQG LGGNAYMMPV GTVVDADQGH SGSTATTEEG RLVGYGAEAG VDPYAAMRRA  540
YELSQGSSSV SVAKVADGYS NNWSSPFNGM G

Functional Description ? help Back to Top
Source	Description
UniProt	Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity). Master regulator of basal/root fate. Essential for root quiescent center (QC) and columella specification, stem cell activity, as well as for establishment of the stem cell niche during embryogenesis. Modulates the root polar auxin transport by regulating the distribution of PIN genes. Essential role in respecifying pattern and polarity in damaged roots. Direct target of the transcriptional corepressor TPL. Expression levels and patterns regulated post-transcriptionally by root meristem growth factors (RGFs). {ECO:0000250, ECO:0000269\|PubMed:15454085, ECO:0000269\|PubMed:15635403, ECO:0000269\|PubMed:16424342, ECO:0000269\|PubMed:20190735}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By auxin accumulation. {ECO:0000269\|PubMed:15454085}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AK364030	0.0	AK364030.1 Hordeum vulgare subsp. vulgare mRNA for predicted protein, complete cds, clone: NIASHv2020P23.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_020196244.1	0.0	AP2-like ethylene-responsive transcription factor BBM2
Swissprot	Q5YGP7	1e-115	PLET2_ARATH; AP2-like ethylene-responsive transcription factor PLT2
TrEMBL	M8AZ41	0.0	M8AZ41_AEGTA; Uncharacterized protein
STRING	EMT06985	0.0	(Aegilops tauschii)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Monocots	OGMP1569	37	110

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G51190.1	1e-104	AP2 family protein

Publications ? help Back to Top
Duarte JM, et al. Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. Mol. Biol. Evol., 2006. 23(2): p. 469-78 [PMID:16280546] Lee DK,Sieburth LE The bps signal: embryonic arrest from an auxin-independent mechanism in bypass triple mutants. Plant Signal Behav, 2012. 7(6): p. 698-700 [PMID:22580686] Hong LW,Yan DW,Liu WC,Chen HG,Lu YT TIME FOR COFFEE controls root meristem size by changes in auxin accumulation in Arabidopsis. J. Exp. Bot., 2014. 65(1): p. 275-86 [PMID:24277277] Tian H,Jia Y,Niu T,Yu Q,Ding Z The key players of the primary root growth and development also function in lateral roots in Arabidopsis. Plant Cell Rep., 2014. 33(5): p. 745-53 [PMID:24504658] Zhao Q, et al. Sulfur nutrient availability regulates root elongation by affecting root indole-3-acetic acid levels and the stem cell niche. J Integr Plant Biol, 2014. 56(12): p. 1151-63 [PMID:24831283] Huang JB, et al. ROP3 GTPase contributes to polar auxin transport and auxin responses and is important for embryogenesis and seedling growth in Arabidopsis. Plant Cell, 2014. 26(9): p. 3501-18 [PMID:25217509] Yang S, et al. The Arabidopsis SWI2/SNF2 Chromatin Remodeling ATPase BRAHMA Targets Directly to PINs and Is Required for Root Stem Cell Niche Maintenance. Plant Cell, 2015. 27(6): p. 1670-80 [PMID:25991732] Jia Y, et al. The Arabidopsis thaliana elongator complex subunit 2 epigenetically affects root development. J. Exp. Bot., 2015. 66(15): p. 4631-42 [PMID:25998905] Zhang M, et al. A tetratricopeptide repeat domain-containing protein SSR1 located in mitochondria is involved in root development and auxin polar transport in Arabidopsis. Plant J., 2015. 83(4): p. 582-99 [PMID:26072661] Shinohara H,Mori A,Yasue N,Sumida K,Matsubayashi Y Identification of three LRR-RKs involved in perception of root meristem growth factor in Arabidopsis. Proc. Natl. Acad. Sci. U.S.A., 2016. 113(14): p. 3897-902 [PMID:27001831] Ou Y, et al. RGF1 INSENSITIVE 1 to 5, a group of LRR receptor-like kinases, are essential for the perception of root meristem growth factor 1 in Arabidopsis thaliana. Cell Res., 2016. 26(6): p. 686-98 [PMID:27229312] Santuari L, et al. The PLETHORA Gene Regulatory Network Guides Growth and Cell Differentiation in Arabidopsis Roots. Plant Cell, 2016. 28(12): p. 2937-2951 [PMID:27920338] Promchuea S,Zhu Y,Chen Z,Zhang J,Gong Z ARF2 coordinates with PLETHORAs and PINs to orchestrate ABA-mediated root meristem activity in Arabidopsis . J Integr Plant Biol, 2017. 59(1): p. 30-43 [PMID:28074634] Du Y,Scheres B PLETHORA transcription factors orchestrate de novo organ patterning during Arabidopsis lateral root outgrowth. Proc. Natl. Acad. Sci. U.S.A., 2017. 114(44): p. 11709-11714 [PMID:29078398] Bustillo-Avendaño E, et al. Regulation of Hormonal Control, Cell Reprogramming, and Patterning during De Novo Root Organogenesis. Plant Physiol., 2018. 176(2): p. 1709-1727 [PMID:29233938]