PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; Caryophyllales; Caryophyllaceae; Caryophylleae; Dianthus

Family

HSF

Protein Properties

Length: 488aa MW: 54488.4 Da PI: 4.4892

Description

HSF family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Dca57201.1	genome	DCA	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HSF_DNA-bind	116.7	1.5e-36	35	127	2	103
HHHHHHHHHCTGGGTTTSEESSSSSEEEES-HHHHHHHTHHHHSTT--HHHHHHHHHHTTEEE---SSBTTTTXTTSEEEEESXXXXXXXXXXXXXX CS HSF_DNA-bind 2 FlkklyeiledeelkeliswsengnsfvvldeeefakkvLpkyFkhsnfaSFvRQLnmYgFkkvkdeekkskskekiweFkhksFkkgkkellekik 98 Fl k+y++++d+++++++sws+++nsfvv+++ efa+++LpkyFkh+nf+SFvRQLn+YgFkkv+ ++ weF+++ F +g+k+ll+ki Dca57201.1 35 FLCKTYDMVDDPATDSIVSWSSTNNSFVVWNPPEFARDLLPKYFKHNNFSSFVRQLNTYGFKKVDPDR---------WEFANEGFLRGQKDLLKKIT 122 9**************************************************************999.........**************** PP XXXXX CS HSF_DNA-bind 99 rkkse 103 r+k++ Dca57201.1 123 RRKKT 127 986 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	1.3E-39	28	119	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	2.72E-36	30	124	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM00415	3.5E-63	31	124	IPR000232	Heat shock factor (HSF)-type, DNA-binding
PRINTS	PR00056	1.4E-19	35	58	IPR000232	Heat shock factor (HSF)-type, DNA-binding
Pfam	PF00447	1.4E-32	35	124	IPR000232	Heat shock factor (HSF)-type, DNA-binding
PRINTS	PR00056	1.4E-19	73	85	IPR000232	Heat shock factor (HSF)-type, DNA-binding
PROSITE pattern	PS00434	0	74	98	IPR000232	Heat shock factor (HSF)-type, DNA-binding
PRINTS	PR00056	1.4E-19	86	98	IPR000232	Heat shock factor (HSF)-type, DNA-binding

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0009408	Biological Process	response to heat
GO:0005634	Cellular Component	nucleus
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0043565	Molecular Function	sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 488 aa Download sequence Send to blast
MDTTTTTTST TAGTADAAVN SQPTPMPVAN APPPFLCKTY DMVDDPATDS IVSWSSTNNS 60 FVVWNPPEFA RDLLPKYFKH NNFSSFVRQL NTYGFKKVDP DRWEFANEGF LRGQKDLLKK 120 ITRRKKTDGH VQQSQQPTHA QNPVGACVEV GKFGLEEEVE RLKRDKNVLM QELVRLRQQQ 180 QTTDSQMQTM LQRLQGMEQR QQQMMSFLAK AVQSPGFLAQ FVQQQSESNR RISEANKKRR 240 LKQDGASETE NSSLADGQIV KYEPLGRQLR NLEESFSGNS DRFFIGDSAS THAMESVSPT 300 NRISEVPATS GAAYLPNSEI SDLRSTPVTA GFETTSTPVV VTTEAANPVT VVHMDSILPE 360 LSSIPDAVPK SDDIRRVDYL VSETGDNEFM DLSSMEINGT LPLDFSIDFD IDKLSPDPDI 420 ESFLNDSAWD PYFNQNLNLP GSNEAELATP ESLPKGQEGP RPENGWDKRQ NVDQLTEQMN 480 LLNSDNNI

Sequence ? help Back to Top

Protein Sequence Length: 488 aa Download sequence Send to blast

MDTTTTTTST TAGTADAAVN SQPTPMPVAN APPPFLCKTY DMVDDPATDS IVSWSSTNNS  60
FVVWNPPEFA RDLLPKYFKH NNFSSFVRQL NTYGFKKVDP DRWEFANEGF LRGQKDLLKK  120
ITRRKKTDGH VQQSQQPTHA QNPVGACVEV GKFGLEEEVE RLKRDKNVLM QELVRLRQQQ  180
QTTDSQMQTM LQRLQGMEQR QQQMMSFLAK AVQSPGFLAQ FVQQQSESNR RISEANKKRR  240
LKQDGASETE NSSLADGQIV KYEPLGRQLR NLEESFSGNS DRFFIGDSAS THAMESVSPT  300
NRISEVPATS GAAYLPNSEI SDLRSTPVTA GFETTSTPVV VTTEAANPVT VVHMDSILPE  360
LSSIPDAVPK SDDIRRVDYL VSETGDNEFM DLSSMEINGT LPLDFSIDFD IDKLSPDPDI  420
ESFLNDSAWD PYFNQNLNLP GSNEAELATP ESLPKGQEGP RPENGWDKRQ NVDQLTEQMN  480
LLNSDNNI

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5d5u_B	1e-25	27	124	18	129	Heat shock factor protein 1
5d5v_B	1e-25	27	124	18	129	Heat shock factor protein 1
5d5v_D	1e-25	27	124	18	129	Heat shock factor protein 1
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Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	235	242	NKKRRLKQ
2	236	241	KKRRLK

Functional Description ? help Back to Top
Source	Description
UniProt	DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. {ECO:0000250}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_010677345.1	0.0	PREDICTED: heat shock factor protein HSF8
Swissprot	Q40152	1e-145	HSF8_SOLLC; Heat shock factor protein HSF8
TrEMBL	A0A0K9RJS2	0.0	A0A0K9RJS2_SPIOL; Uncharacterized protein
STRING	XP_010677345.1	0.0	(Beta vulgaris)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G32330.1	1e-105	heat shock transcription factor A1D

Publications ? help Back to Top
Zhu B, et al. Identification and characterization of a novel heat shock transcription factor gene, GmHsfA1, in soybeans (Glycine max). J. Plant Res., 2006. 119(3): p. 247-56 [PMID:16570125] Cai SY, et al. HsfA1a upregulates melatonin biosynthesis to confer cadmium tolerance in tomato plants. J. Pineal Res., 2017. [PMID:28095626] Zhou J, et al. Heat Shock Factor HsfA1a Is Essential for R Gene-Mediated Nematode Resistance and Triggers H2O2 Production1. Plant Physiol., 2018. 176(3): p. 2456-2471 [PMID:29339397]