PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Cucsa.353040.1
Common NameCsa_4G644740, LOC101212143
Organism
Cucumis sativus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis
Family AP2
Protein Properties Length: 574aa    MW: 64292.3 Da    PI: 8.1089
Description AP2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Cucsa.353040.1genomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1AP250.36e-16238297155
             AP2   1 sgykGVrwdkkrgrWvAeIrd.pse.ng..kr.krfslgkfgtaeeAakaaiaarkkleg 55 
                     s+y+GV++++++gr++A+++d  ++  g  ++ ++++lg ++ +e+Aa+a++ a++k++g
  Cucsa.353040.1 238 SQYRGVTRHRWTGRYEAHLWDnSCKkEGqtRKgRQVYLGGYDMEEKAARAYDLAALKYWG 297
                     78*******************988886678446*************************98 PP
2AP251.62.4e-16340391155
             AP2   1 sgykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 
                     s y+GV+++++ grW A+I  +     +k  +lg+fgt eeAa+a++ a+ k++g
  Cucsa.353040.1 340 SIYRGVTRHHQHGRWQARIGRVAG---NKDLYLGTFGTQEEAAEAYDIAAIKFRG 391
                     57****************988532...5*************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF008471.3E-12238297IPR001471AP2/ERF domain
CDDcd000182.34E-22238305No hitNo description
SuperFamilySSF541719.15E-17238306IPR016177DNA-binding domain
Gene3DG3DSA:3.30.730.102.1E-16239306IPR001471AP2/ERF domain
SMARTSM003805.2E-29239311IPR001471AP2/ERF domain
PROSITE profilePS5103219.269239305IPR001471AP2/ERF domain
PRINTSPR003671.1E-6240251IPR001471AP2/ERF domain
PfamPF008473.7E-11340391IPR001471AP2/ERF domain
SuperFamilySSF541711.11E-17340400IPR016177DNA-binding domain
CDDcd000187.80E-26340401No hitNo description
Gene3DG3DSA:3.30.730.102.7E-18341400IPR001471AP2/ERF domain
PROSITE profilePS5103218.821341399IPR001471AP2/ERF domain
SMARTSM003803.2E-33341405IPR001471AP2/ERF domain
PRINTSPR003671.1E-6381401IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 574 aa     Download sequence    Send to blast
MAMEASSEPQ QHSHYHHRGQ VTSAVAVSNT MSNSFLASHH YNGDFLSVVP LKSDGSLCIM  60
DSINTSQPQD ILPNISPKLE DFLGGATHGK ETTALSLDSI YYDQNAEVGS ERQHSLNLLN  120
QQEQQQHILF HSQRYYSAMY QYPAENPDNE SHIASYCSEI RQDMEQRING CCFGGMNCQD  180
LKPLSLSMSP GSQSSCVTTP SQISQPGPST MEIKKRALAS QKQPVHRKSI DTFGQRTSQY  240
RGVTRHRWTG RYEAHLWDNS CKKEGQTRKG RQVYLGGYDM EEKAARAYDL AALKYWGSST  300
HLNFPLKNYE LEIEEMKNMN RQEYVAHLRR KSSGFSRGAS IYRGVTRHHQ HGRWQARIGR  360
VAGNKDLYLG TFGTQEEAAE AYDIAAIKFR GANAVTNFDT SRYDVERIIA SSSLLSGEFA  420
RRKKEHKPTN TIERKEPKQN VTQTDEGLEM STNLDWRAVF HDNLLLNPSA SVESIDQKSM  480
TSSRYVNHVI GVVETESSNQ ETVNDSRKYK THFSNASSVV SSLSSSRETS PDKSNGSSSV  540
LFAKSPFGSN GSNWLPSPQM RLAPISLPVW NDA*
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that recognizes and binds to the DNA consensus sequence 5'-CAC[AG]N[AT]TNCCNANG-3'. Required for the initiation and growth of ovules integumenta, and for the development of female gametophyte. Plays a critical role in the development of gynoecium marginal tissues (e.g. stigma, style and septa), and in the fusion of carpels and of medial ridges leading to ovule primordia. Also involved in organs initiation and development, including floral organs. Maintains the meristematic competence of cells and consequently sustains expression of cell cycle regulators during organogenesis, thus controlling the final size of each organ by controlling their cell number. Regulates INO autoinduction and expression pattern. As ANT promotes petal cell identity and mediates down-regulation of AG in flower whorl 2, it functions as a class A homeotic gene. {ECO:0000269|PubMed:10528263, ECO:0000269|PubMed:10639184, ECO:0000269|PubMed:10948255, ECO:0000269|PubMed:11041883, ECO:0000269|PubMed:12183381, ECO:0000269|PubMed:12271029, ECO:0000269|PubMed:12655002, ECO:0000269|PubMed:8742706, ECO:0000269|PubMed:8742707, ECO:0000269|PubMed:9001406, ECO:0000269|PubMed:9093862, ECO:0000269|PubMed:9118807}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankLN6818610.0LN681861.1 Cucumis melo genomic scaffold, anchoredscaffold00029.
GenBankLN7132610.0LN713261.1 Cucumis melo genomic chromosome, chr_7.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_004141413.10.0PREDICTED: AP2-like ethylene-responsive transcription factor ANT isoform X1
SwissprotQ389141e-147ANT_ARATH; AP2-like ethylene-responsive transcription factor ANT
TrEMBLA0A0A0L3W00.0A0A0A0L3W0_CUCSA; Uncharacterized protein
STRINGXP_004141413.10.0(Cucumis sativus)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF91634114
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G37750.11e-125AP2 family protein
Publications ? help Back to Top
  1. Ren Y, et al.
    An integrated genetic and cytogenetic map of the cucumber genome.
    PLoS ONE, 2009. 4(6): p. e5795
    [PMID:19495411]
  2. Guo S, et al.
    Transcriptome sequencing and comparative analysis of cucumber flowers with different sex types.
    BMC Genomics, 2010. 11: p. 384
    [PMID:20565788]
  3. Li Z, et al.
    RNA-Seq improves annotation of protein-coding genes in the cucumber genome.
    BMC Genomics, 2011. 12: p. 540
    [PMID:22047402]
  4. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  5. Horstman A,Willemsen V,Boutilier K,Heidstra R
    AINTEGUMENTA-LIKE proteins: hubs in a plethora of networks.
    Trends Plant Sci., 2014. 19(3): p. 146-57
    [PMID:24280109]
  6. Li C, et al.
    Ectopic expression of a maize hybrid down-regulated gene ZmARF25 decreases organ size by affecting cellular proliferation in Arabidopsis.
    PLoS ONE, 2014. 9(4): p. e94830
    [PMID:24756087]
  7. Wynn AN,Seaman AA,Jones AL,Franks RG
    Novel functional roles for PERIANTHIA and SEUSS during floral organ identity specification, floral meristem termination, and gynoecial development.
    Front Plant Sci, 2014. 5: p. 130
    [PMID:24778638]
  8. Randall RS, et al.
    AINTEGUMENTA and the D-type cyclin CYCD3;1 regulate root secondary growth and respond to cytokinins.
    Biol Open, 2015. 4(10): p. 1229-36
    [PMID:26340943]
  9. Meng LS,Wang ZB,Yao SQ,Liu A
    The ARF2-ANT-COR15A gene cascade regulates ABA-signaling-mediated resistance of large seeds to drought in Arabidopsis.
    J. Cell. Sci., 2015. 128(21): p. 3922-32
    [PMID:26395398]
  10. Yamaguchi N,Jeong CW,Nole-Wilson S,Krizek BA,Wagner D
    AINTEGUMENTA and AINTEGUMENTA-LIKE6/PLETHORA3 Induce LEAFY Expression in Response to Auxin to Promote the Onset of Flower Formation in Arabidopsis.
    Plant Physiol., 2016. 170(1): p. 283-93
    [PMID:26537561]
  11. Krizek BA, et al.
    RNA-Seq Links the Transcription Factors AINTEGUMENTA and AINTEGUMENTA-LIKE6 to Cell Wall Remodeling and Plant Defense Pathways.
    Plant Physiol., 2016. 171(3): p. 2069-84
    [PMID:27208279]
  12. Han H,Krizek BA
    AINTEGUMENTA-LIKE6 can functionally replace AINTEGUMENTA but alters Arabidopsis flower development when misexpressed at high levels.
    Plant Mol. Biol., 2016. 92(4-5): p. 597-612
    [PMID:27605095]
  13. Karpinska B,Alomrani SO,Foyer CH
    Inhibitor-induced oxidation of the nucleus and cytosol in Arabidopsis thaliana: implications for organelle to nucleus retrograde signalling.
    Philos. Trans. R. Soc. Lond., B, Biol. Sci., 2018.
    [PMID:28808105]
  14. Li B, et al.
    Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis.
    Plant Cell, 2018. 30(1): p. 178-195
    [PMID:29317470]