PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis

Family

C2H2

Protein Properties

Length: 458aa MW: 51404.8 Da PI: 9.0305

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Cucsa.181200.1	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	15.8	4.1e-05	63	83	3	23
ETTTTEEESSHHHHHHHHHHT CS zf-C2H2 3 CpdCgksFsrksnLkrHirtH 23 C++Cgk F r nL+ H r H Cucsa.181200.1 63 CEICGKGFQRDQNLQLHRRGH 83 *******************88 PP
2	zf-C2H2	12.9	0.00033	139	161	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 +kC++C+k + +s+ k H +t+ Cucsa.181200.1 139 WKCEKCSKKYAVQSDWKAHSKTC 161 58*****************9998 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:3.30.160.60	3.9E-5	60	83	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamily	SSF57667	2.19E-6	60	83	No hit	No description
PROSITE profile	PS50157	11.489	61	83	IPR007087	Zinc finger, C2H2
SMART	SM00355	0.076	61	83	IPR015880	Zinc finger, C2H2-like
PROSITE pattern	PS00028	0	63	83	IPR007087	Zinc finger, C2H2
Gene3D	G3DSA:3.30.160.60	5.2E-4	127	160	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamily	SSF57667	2.19E-6	134	159	No hit	No description
SMART	SM00355	140	139	159	IPR015880	Zinc finger, C2H2-like

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003676	Molecular Function	nucleic acid binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 458 aa Download sequence Send to blast
MSEEQTISSA FICSIPSLGS INNNNNPSVI VKKKRNLPGN PDPEAEVVSL SPKTLMATNR 60 FLCEICGKGF QRDQNLQLHR RGHNLPWKLK QRSNGNKEPR KRVYVCPEKS CVHHHPSRAL 120 GDLTGIKKHF CRKHGEKKWK CEKCSKKYAV QSDWKAHSKT CGTKEYKCDC GTPFSRFESY 180 HKIQSDYLKL YHRSFECMTF FLSNTIHRRD SYVTHRAYCV ALAEETARLN AASTNIANNN 240 NSLADNYINN NNPPQLFFPN YSSNLFKPNE TSPFFFNNNN TPTIPLPFWI PTNPHQINNF 300 HYPTTTTTTA TATTNSDVLS VPSLFSNEEQ QSSHQFMSSS PNMSATLLLQ KAAQIGVTTD 360 HPSSLMESLG LKFSSITDGK ALLSGIYGSM INSNSNNVII PLSEENHHHH HYSAPPAKRM 420 RHTVSEESVN GGEGETRDFL GVGMHTICHP STVNGWI*

Sequence ? help Back to Top

Protein Sequence Length: 458 aa Download sequence Send to blast

MSEEQTISSA FICSIPSLGS INNNNNPSVI VKKKRNLPGN PDPEAEVVSL SPKTLMATNR  60
FLCEICGKGF QRDQNLQLHR RGHNLPWKLK QRSNGNKEPR KRVYVCPEKS CVHHHPSRAL  120
GDLTGIKKHF CRKHGEKKWK CEKCSKKYAV QSDWKAHSKT CGTKEYKCDC GTPFSRFESY  180
HKIQSDYLKL YHRSFECMTF FLSNTIHRRD SYVTHRAYCV ALAEETARLN AASTNIANNN  240
NSLADNYINN NNPPQLFFPN YSSNLFKPNE TSPFFFNNNN TPTIPLPFWI PTNPHQINNF  300
HYPTTTTTTA TATTNSDVLS VPSLFSNEEQ QSSHQFMSSS PNMSATLLLQ KAAQIGVTTD  360
HPSSLMESLG LKFSSITDGK ALLSGIYGSM INSNSNNVII PLSEENHHHH HYSAPPAKRM  420
RHTVSEESVN GGEGETRDFL GVGMHTICHP STVNGWI*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5b3h_C	2e-27	135	235	3	71	Zinc finger protein JACKDAW
5b3h_F	2e-27	135	235	3	71	Zinc finger protein JACKDAW
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds to the DNA sequence 5'-CTTTTGTCC-3' (PubMed:21265895, PubMed:25929516). Regulates photoperiodic flowering by modulating sugar transport and metabolism (PubMed:21265895, PubMed:25929516). Regulates SUS1 and SUS4 (PubMed:21265895). Transcription factor that regulates tissue boundaries and asymmetric cell division (PubMed:25829440). Contributes to the sequestration of 'SHORT-ROOT' to the nucleus (PubMed:25829440). {ECO:0000269\|PubMed:21265895, ECO:0000269\|PubMed:25829440, ECO:0000269\|PubMed:25929516}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by 'SHORT-ROOT' (SHR)(PubMed:16640459). Strongly down-regulated by sugar deprivation, but not regulated by day-length. {ECO:0000269\|PubMed:16640459}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	LN681792	0.0	LN681792.1 Cucumis melo genomic scaffold, anchoredscaffold00034.
GenBank	LN713255	0.0	LN713255.1 Cucumis melo genomic chromosome, chr_1.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_004144605.2	0.0	PREDICTED: zinc finger protein NUTCRACKER-like
Swissprot	Q9FFH3	1e-125	IDD8_ARATH; Zinc finger protein NUTCRACKER
TrEMBL	A0A0A0K6P7	0.0	A0A0A0K6P7_CUCSA; Uncharacterized protein
STRING	XP_004144605.1	0.0	(Cucumis sativus)
STRING	XP_004169268.1	0.0	(Cucumis sativus)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF4626	29	51

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G03840.1	1e-93	C2H2 family protein

Link Out ? help Back to Top
Phytozome	Cucsa.181200.1

Publications ? help Back to Top
Moreno-Risueno MA, et al. Transcriptional control of tissue formation throughout root development. Science, 2015. 350(6259): p. 426-30 [PMID:26494755] Long Y, et al. In vivo FRET-FLIM reveals cell-type-specific protein interactions in Arabidopsis roots. Nature, 2017. 548(7665): p. 97-102 [PMID:28746306]