PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis

Family

HD-ZIP

Protein Properties

Length: 325aa MW: 36886.6 Da PI: 4.6051

Description

HD-ZIP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Cucsa.104200.1	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Homeobox	59.6	5.2e-19	57	110	3	56
--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS Homeobox 3 kRttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56 k+++++ +q+++Le+ Fe ++++ e++ +LA++lgL+ rqV vWFqNrRa++k Cucsa.104200.1 57 KKRRLSVDQVKALEKTFEIENKLEPERKVKLAQELGLQPRQVAVWFQNRRARWK 110 456899***********************************************9 PP
2	HD-ZIP_I/II	126.9	8.8e-41	56	148	1	93
HD-ZIP_I/II 1 ekkrrlskeqvklLEesFeeeekLeperKvelareLglqprqvavWFqnrRARtktkqlEkdyeaLkraydalkeenerLekeveeLreelke 93 ekkrrls +qvk+LE++Fe e+kLeperKv+la+eLglqprqvavWFqnrRAR+ktkqlE+dy Lk++y++lk++ ++L++++++L +e+ke Cucsa.104200.1 56 EKKRRLSVDQVKALEKTFEIENKLEPERKVKLAQELGLQPRQVAVWFQNRRARWKTKQLERDYGLLKANYESLKRSFDTLQQDNDALLKEIKE 148 69*************************************************************************************999987 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF46689	1.3E-19	40	114	IPR009057	Homeodomain-like
SMART	SM00389	5.4E-19	55	116	IPR001356	Homeobox domain
PROSITE profile	PS50071	16.989	56	112	IPR001356	Homeobox domain
Pfam	PF00046	3.3E-16	57	110	IPR001356	Homeobox domain
CDD	cd00086	2.13E-17	57	113	No hit	No description
Gene3D	G3DSA:1.10.10.60	3.1E-20	59	119	IPR009057	Homeodomain-like
PRINTS	PR00031	9.3E-6	83	92	IPR000047	Helix-turn-helix motif
PROSITE pattern	PS00027	0	87	110	IPR017970	Homeobox, conserved site
PRINTS	PR00031	9.3E-6	92	108	IPR000047	Helix-turn-helix motif
Pfam	PF02183	3.5E-16	112	153	IPR003106	Leucine zipper, homeobox-associated

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0009414	Biological Process	response to water deprivation
GO:0009788	Biological Process	negative regulation of abscisic acid-activated signaling pathway
GO:0045893	Biological Process	positive regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0043565	Molecular Function	sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 325 aa Download sequence Send to blast
MKRHGSSDSL GALMSVCPTS EEQSPRNSHV YGREFQSMLD GLDEEGSIEE HCHVGEKKRR 60 LSVDQVKALE KTFEIENKLE PERKVKLAQE LGLQPRQVAV WFQNRRARWK TKQLERDYGL 120 LKANYESLKR SFDTLQQDND ALLKEIKELK SKLEEEKTES NLSVKEEIFV SESDNLLIEQ 180 TTNHLPVDHI SLPVASDHSD DFNYESFRTV GADDGDDQRV EVSLFTDFKD GSSDSDSSAI 240 LNEDNSPNAV VSSATAGMLQ SHHQILSSPA TSLNCYPFQK AAYNNAQQFV KIEEHNFFSG 300 EETCNLFSDE QAPSMHWYCP DQWN*

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	104	112	RRARWKTKQ
2	125	130	ESLKRS

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that may act as growth regulators in response to water deficit. Interacts with the core sequence 5'-CAATTATTA-3' of promoters in response to ABA and in an ABI1-dependent manner. Involved in the negative regulation of the ABA signaling pathway. {ECO:0000269\|PubMed:10527431, ECO:0000269\|PubMed:12065416}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00271	DAP	Transfer from AT2G22430	Download

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By water deficit, by abscisic acid (ABA) and by salt stress. Self expression regulation. {ECO:0000269\|PubMed:10527431, ECO:0000269\|PubMed:12065416, ECO:0000269\|PubMed:16055682}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	LN681875	0.0	LN681875.1 Cucumis melo genomic scaffold, anchoredscaffold00007.
GenBank	LN713262	0.0	LN713262.1 Cucumis melo genomic chromosome, chr_8.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_004143453.1	0.0	PREDICTED: homeobox-leucine zipper protein ATHB-6
Swissprot	P46668	2e-80	ATHB6_ARATH; Homeobox-leucine zipper protein ATHB-6
TrEMBL	A0A0A0KGQ3	0.0	A0A0A0KGQ3_CUCSA; Uncharacterized protein
STRING	XP_004143453.1	0.0	(Cucumis sativus)
STRING	XP_004173863.1	0.0	(Cucumis sativus)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF1868	34	89

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G22430.1	2e-74	homeobox protein 6

Link Out ? help Back to Top
Phytozome	Cucsa.104200.1
Entrez Gene	101205742

Publications ? help Back to Top
Ren Y, et al. An integrated genetic and cytogenetic map of the cucumber genome. PLoS ONE, 2009. 4(6): p. e5795 [PMID:19495411] Guo S, et al. Transcriptome sequencing and comparative analysis of cucumber flowers with different sex types. BMC Genomics, 2010. 11: p. 384 [PMID:20565788] Li Z, et al. RNA-Seq improves annotation of protein-coding genes in the cucumber genome. BMC Genomics, 2011. 12: p. 540 [PMID:22047402] Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Song L, et al. A transcription factor hierarchy defines an environmental stress response network. Science, 2017. [PMID:27811239]