PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Cucsa.103400.1
Common NameCsa_6G496390, LOC101203323
Organism
Cucumis sativus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis
Family AP2
Protein Properties Length: 639aa    MW: 70565.4 Da    PI: 7.7955
Description AP2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Cucsa.103400.1genomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1AP2513.6e-16291350155
             AP2   1 sgykGVrwdkkrgrWvAeIrd.pse.ng..kr.krfslgkfgtaeeAakaaiaarkkleg 55 
                     s+y+GV++++++gr++A+++d  ++  g  ++ ++++lg ++ +e+Aa+a++ a++k++g
  Cucsa.103400.1 291 SQYRGVTRHRWTGRYEAHLWDnSCKkEGqsRKgRQVYLGGYDMEEKAARAYDLAALKYWG 350
                     78*******************988886678446*************************98 PP
2AP232.62e-10410453955
             AP2   9 dkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 
                     +++ grW A+I  +     +k  +lg+f t eeAa+a++ a+ k++g
  Cucsa.103400.1 410 HHQHGRWQARIGRVAG---NKDLYLGTFSTQEEAAEAYDIAAIKFRG 453
                     456777****988532...5************************998 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF008476.2E-13291350IPR001471AP2/ERF domain
SuperFamilySSF541711.05E-16291360IPR016177DNA-binding domain
CDDcd000186.28E-22291358No hitNo description
SMARTSM003802.6E-29292364IPR001471AP2/ERF domain
PROSITE profilePS5103219.203292358IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.104.3E-16292359IPR001471AP2/ERF domain
PRINTSPR003677.0E-5293304IPR001471AP2/ERF domain
PRINTSPR003677.0E-5340360IPR001471AP2/ERF domain
CDDcd000186.51E-23393463No hitNo description
PROSITE profilePS5103217.912394461IPR001471AP2/ERF domain
SMARTSM003801.3E-28394467IPR001471AP2/ERF domain
PfamPF008472.2E-5410453IPR001471AP2/ERF domain
SuperFamilySSF541712.68E-14410462IPR016177DNA-binding domain
Gene3DG3DSA:3.30.730.109.8E-15411461IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0007276Biological Processgamete generation
GO:0010492Biological Processmaintenance of shoot apical meristem identity
GO:0042127Biological Processregulation of cell proliferation
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 639 aa     Download sequence    Send to blast
MNNVNGNNCN WLGFSVSPNV NMELSSSAAT SVSPSIPANL FHSPSQFNYG ICYGVDGEHG  60
AFYSPLSAMP LKSDGSICSM EALSRQHPQV VSSSTPKLED FFGGATMGSH HYESNDREAM  120
ALSLDSIFCH QNPTHEPNNQ SFAHFSSLRS RELMLQDSKV ILPDGCNLQQ QQQHPGVAQS  180
DISGMKNWTV PRNYAATNNG SFEQKMVSCM SENGGESGSI NAMAYGDLQS LSLSMTMSPS  240
SQSSCVTATQ HVSPAMTDCS AMDTKKRGHE KVDQKQIVHR KSLDTFGQRT SQYRGVTRHR  300
WTGRYEAHLW DNSCKKEGQS RKGRQVYLGG YDMEEKAARA YDLAALKYWG PSTHINFPLE  360
NYQKELEEMK NMSRQEYVAH LRRRSSGFSR GASIYRGVTR SNKSQLKALH HQHGRWQARI  420
GRVAGNKDLY LGTFSTQEEA AEAYDIAAIK FRGMNAVTNF DITRYDVERI IASNTLLSGD  480
LAKRKQQPEF DNESLRQSPP THNSNSEAMT LPSQSSSQSE SDWKMALYHS SQQLIPKPRM  540
LSAINDDGSQ LGVEDSARMG AHFSNASSMV TSCSLSSSRE ESPDKTSLSM VFGMPQSTSK  600
PFATSANNMN TSWIASAQQI RAANCMSQLP VFAAWTDT*
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that recognizes and binds to the DNA consensus sequence 5'-CAC[AG]N[AT]TNCCNANG-3'. Required for the initiation and growth of ovules integumenta, and for the development of female gametophyte. Plays a critical role in the development of gynoecium marginal tissues (e.g. stigma, style and septa), and in the fusion of carpels and of medial ridges leading to ovule primordia. Also involved in organs initiation and development, including floral organs. Maintains the meristematic competence of cells and consequently sustains expression of cell cycle regulators during organogenesis, thus controlling the final size of each organ by controlling their cell number. Regulates INO autoinduction and expression pattern. As ANT promotes petal cell identity and mediates down-regulation of AG in flower whorl 2, it functions as a class A homeotic gene. {ECO:0000269|PubMed:10528263, ECO:0000269|PubMed:10639184, ECO:0000269|PubMed:10948255, ECO:0000269|PubMed:11041883, ECO:0000269|PubMed:12183381, ECO:0000269|PubMed:12271029, ECO:0000269|PubMed:12655002, ECO:0000269|PubMed:8742706, ECO:0000269|PubMed:8742707, ECO:0000269|PubMed:9001406, ECO:0000269|PubMed:9093862, ECO:0000269|PubMed:9118807}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00088SELEXTransfer from AT4G37750Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankLN6818750.0LN681875.1 Cucumis melo genomic scaffold, anchoredscaffold00007.
GenBankLN7132620.0LN713262.1 Cucumis melo genomic chromosome, chr_8.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011657909.10.0PREDICTED: AP2-like ethylene-responsive transcription factor ANT isoform X1
SwissprotQ389141e-169ANT_ARATH; AP2-like ethylene-responsive transcription factor ANT
TrEMBLA0A0A0KLK40.0A0A0A0KLK4_CUCSA; Uncharacterized protein
STRINGXP_008440434.10.0(Cucumis melo)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF91634114
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G37750.11e-145AP2 family protein
Publications ? help Back to Top
  1. Ren Y, et al.
    An integrated genetic and cytogenetic map of the cucumber genome.
    PLoS ONE, 2009. 4(6): p. e5795
    [PMID:19495411]
  2. Guo S, et al.
    Transcriptome sequencing and comparative analysis of cucumber flowers with different sex types.
    BMC Genomics, 2010. 11: p. 384
    [PMID:20565788]
  3. Li Z, et al.
    RNA-Seq improves annotation of protein-coding genes in the cucumber genome.
    BMC Genomics, 2011. 12: p. 540
    [PMID:22047402]
  4. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  5. Horstman A,Willemsen V,Boutilier K,Heidstra R
    AINTEGUMENTA-LIKE proteins: hubs in a plethora of networks.
    Trends Plant Sci., 2014. 19(3): p. 146-57
    [PMID:24280109]
  6. Li C, et al.
    Ectopic expression of a maize hybrid down-regulated gene ZmARF25 decreases organ size by affecting cellular proliferation in Arabidopsis.
    PLoS ONE, 2014. 9(4): p. e94830
    [PMID:24756087]
  7. Wynn AN,Seaman AA,Jones AL,Franks RG
    Novel functional roles for PERIANTHIA and SEUSS during floral organ identity specification, floral meristem termination, and gynoecial development.
    Front Plant Sci, 2014. 5: p. 130
    [PMID:24778638]
  8. Randall RS, et al.
    AINTEGUMENTA and the D-type cyclin CYCD3;1 regulate root secondary growth and respond to cytokinins.
    Biol Open, 2015. 4(10): p. 1229-36
    [PMID:26340943]
  9. Meng LS,Wang ZB,Yao SQ,Liu A
    The ARF2-ANT-COR15A gene cascade regulates ABA-signaling-mediated resistance of large seeds to drought in Arabidopsis.
    J. Cell. Sci., 2015. 128(21): p. 3922-32
    [PMID:26395398]
  10. Yamaguchi N,Jeong CW,Nole-Wilson S,Krizek BA,Wagner D
    AINTEGUMENTA and AINTEGUMENTA-LIKE6/PLETHORA3 Induce LEAFY Expression in Response to Auxin to Promote the Onset of Flower Formation in Arabidopsis.
    Plant Physiol., 2016. 170(1): p. 283-93
    [PMID:26537561]
  11. Krizek BA, et al.
    RNA-Seq Links the Transcription Factors AINTEGUMENTA and AINTEGUMENTA-LIKE6 to Cell Wall Remodeling and Plant Defense Pathways.
    Plant Physiol., 2016. 171(3): p. 2069-84
    [PMID:27208279]
  12. Han H,Krizek BA
    AINTEGUMENTA-LIKE6 can functionally replace AINTEGUMENTA but alters Arabidopsis flower development when misexpressed at high levels.
    Plant Mol. Biol., 2016. 92(4-5): p. 597-612
    [PMID:27605095]
  13. Karpinska B,Alomrani SO,Foyer CH
    Inhibitor-induced oxidation of the nucleus and cytosol in Arabidopsis thaliana: implications for organelle to nucleus retrograde signalling.
    Philos. Trans. R. Soc. Lond., B, Biol. Sci., 2018.
    [PMID:28808105]
  14. Li B, et al.
    Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis.
    Plant Cell, 2018. 30(1): p. 178-195
    [PMID:29317470]