PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Cucsa.098190.1
Organism
Cucumis sativus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis
Family E2F/DP
Protein Properties Length: 385aa    MW: 42940 Da    PI: 9.0688
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Cucsa.098190.1genomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP73.13e-232388171
         E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                    rk+ksL+ll+++fl+l+++     + l+++a++L    v  +rRRiYDi+NVLe+++++++k+kn+++w+g
  Cucsa.098190.1 23 RKQKSLGLLCSNFLSLYNHDGVHSIGLDDAASRL---GV--ERRRIYDIVNVLESVGVLSRKAKNQYSWNG 88
                    79*****************999************...**..****************************98 PP
2E2F_TDP77.31.5e-24158238171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                     r+eksL lltq+f+kl+ +s+ ++++l+e+ak L+ +      +++k+RR+YDi+NVL+++nliek     ++k+++rw g
  Cucsa.098190.1 158 RREKSLALLTQNFVKLFICSHVNMISLDEAAKLLLGDghnssIMRTKVRRLYDIANVLSSMNLIEKthttdTRKPAFRWLG 238
                     689**************************************999**************************99*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.105.5E-261989IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467855.14E-162286IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013725.4E-282388IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023195.2E-202488IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.101.5E-23155239IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013729.7E-32158238IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467859.11E-13160239IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023192.3E-19160238IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 385 aa     Download sequence    Send to blast
MAALPSSSAL PDSSSSRHHT YSRKQKSLGL LCSNFLSLYN HDGVHSIGLD DAASRLGVER  60
RRIYDIVNVL ESVGVLSRKA KNQYSWNGFG AIPKALQDLK EEGLRENCSA SDGNDYAKVS  120
DDEDEDERFS NPTGSQTSTA AVPKSSSSSL KAVSADNRRE KSLALLTQNF VKLFICSHVN  180
MISLDEAAKL LLGDGHNSSI MRTKVRRLYD IANVLSSMNL IEKTHTTDTR KPAFRWLGVR  240
GKVKNEPTLL PESRKRAFGT DVTNVSYKKT KAENSAYQGF NHCLNMQKLV QCDNSSQEDS  300
QNSQDQECER TSKSYQFGPF APVSVAKVGV LDNNNVKRTH DWENLSSTFR PQYHNQALKE  360
LFSHYVEAWK SWYSEAVKKP IQIS*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A1e-42222303228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankLN6819320.0LN681932.1 Cucumis melo genomic scaffold, anchoredscaffold00001.
GenBankLN7132660.0LN713266.1 Cucumis melo genomic chromosome, chr_12.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011651400.10.0PREDICTED: E2F transcription factor-like E2FE isoform X1
SwissprotQ8LSZ41e-130E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A1S3AVZ10.0A0A1S3AVZ1_CUCME; E2F transcription factor-like E2FE isoform X1
STRINGXP_008438024.10.0(Cucumis melo)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF36683366
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-127DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]