PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Cucsa.076000.1
Common NameCsa_5G587130, LOC101218905
Organism
Cucumis sativus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis
Family C2H2
Protein Properties Length: 359aa    MW: 40938.6 Da    PI: 6.6376
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Cucsa.076000.1genomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H212.30.00056789323
                    ET..TTTEEESSHHHHHHHHHHT CS
         zf-C2H2  3 Cp..dCgksFsrksnLkrHirtH 23
                    C+   Cgk+F +   L++H   H
  Cucsa.076000.1 67 CSydGCGKTFIDAGALRKHSHIH 89
                    78889**************7766 PP
2zf-C2H216.52.3e-0594118123
                     EEET..TTTEEESSHHHHHHHHHHT CS
         zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                     y+C+   Cgk F ++s LkrH   H
  Cucsa.076000.1  94 YVCHyeGCGKKFLDSSKLKRHFLIH 118
                     9********************8877 PP
3zf-C2H221.85.1e-07124148123
                     EEET..TTTEEESSHHHHHHHHHHT CS
         zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                     ++Cp   Cgk Fs   nL++H++tH
  Cucsa.076000.1 124 FVCPheGCGKAFSLDFNLRSHMKTH 148
                     89**********************9 PP
4zf-C2H218.94e-06154178123
                     EEET..TTTEEESSHHHHHHHHHHT CS
         zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                     + Cp  dCgk+F + + Lk+Hi +H
  Cucsa.076000.1 154 HICPyaDCGKRFAHEYKLKNHITSH 178
                     68*********************96 PP
5zf-C2H213.90.00016217242123
                     EEET..TTTEEESSHHHHHHHHHH.T CS
         zf-C2H2   1 ykCp..dCgksFsrksnLkrHirt.H 23 
                     y Cp   C k + + + Lk H+r+ H
  Cucsa.076000.1 217 YACPyeGCEKAYIHEYKLKLHLRReH 242
                     89**********************99 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:3.30.160.601.2E-136091IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profilePS5015710.7836594IPR007087Zinc finger, C2H2
SMARTSM003550.00286589IPR015880Zinc finger, C2H2-like
PROSITE patternPS0002806789IPR007087Zinc finger, C2H2
SuperFamilySSF576671.92E-868118No hitNo description
Gene3DG3DSA:3.30.160.602.2E-1492114IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003550.002494118IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015713.92194123IPR007087Zinc finger, C2H2
PROSITE patternPS00028096118IPR007087Zinc finger, C2H2
SuperFamilySSF576672.81E-14105158No hitNo description
Gene3DG3DSA:3.30.160.603.3E-20115148IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003553.1E-4124148IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015712.695124153IPR007087Zinc finger, C2H2
PROSITE patternPS000280126148IPR007087Zinc finger, C2H2
SuperFamilySSF576675.25E-5148181No hitNo description
Gene3DG3DSA:3.30.160.601.1E-8149180IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003550.0013154178IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015710.097154183IPR007087Zinc finger, C2H2
PROSITE patternPS000280156179IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.602.1E-9211240IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamilySSF576678.72E-6212240No hitNo description
SMARTSM003550.0089217242IPR015880Zinc finger, C2H2-like
PROSITE profilePS501579.328217244IPR007087Zinc finger, C2H2
PROSITE patternPS000280219242IPR007087Zinc finger, C2H2
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0045892Biological Processnegative regulation of transcription, DNA-templated
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0043565Molecular Functionsequence-specific DNA binding
GO:0046872Molecular Functionmetal ion binding
Sequence ? help Back to Top
Protein Sequence    Length: 359 aa     Download sequence    Send to blast
RPIVKNKSPP VKWIKEWVPQ DVVATGGKCF LLKWVTEDTL KALKEKAKQS EAPEPEPEPT  60
TEVLFLCSYD GCGKTFIDAG ALRKHSHIHG ERQYVCHYEG CGKKFLDSSK LKRHFLIHTG  120
ERDFVCPHEG CGKAFSLDFN LRSHMKTHSQ ENYHICPYAD CGKRFAHEYK LKNHITSHHE  180
KNVTAEVVKY TPPSEKQTKV SKPSGGAYAS ASSDRPYACP YEGCEKAYIH EYKLKLHLRR  240
EHPGHLVEDN GNAQHNGENE VEASDQDVYG GKRANVKNQK QNKPKPNLKL PPSKISQRKG  300
TTPSPAPMSV VKKSWPVKEE NYEEEDSEET EEEDRDNVEE GWRYAENEED DEETEYED*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1ubd_C1e-35671788119PROTEIN (YY1 ZINC FINGER DOMAIN)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtDual-function transcription factor with both repression and activation activities. Binds to 5'-CCATATT-3' motif in target gene promoters (e.g. ABR1) (PubMed:26961720). Binds also to G-rich DNA motif 5'-GGGGGCAGTGG-3' (PubMed:22508367). Regulates the expression of genes involved in diverse cellular pathways, including glucose metabolism, photosynthesis, phototropism and stress response (e.g. salt, drought and osmotic stress) (PubMed:22508367, PubMed:26961720). Regulates plant immunity, especially during necrotrophic fungal infection (e.g. B.cinerea) (PubMed:24451981). Binds to ABR1 promoter and promotes its expression, thus negatively regulating the abscisic acid (ABA) signaling pathway. Represses ABA- and salt-responsive genes expression (PubMed:26961720). {ECO:0000269|PubMed:22508367, ECO:0000269|PubMed:24451981, ECO:0000269|PubMed:26961720}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by abscisic acid (ABA) in an ABI1- and ABI4-dependent manner. Stimulated by stress conditions including high salt, osmotic stress (e.g. mannitol) and dehydration. May be induced by ABI4 but repressed by ABR1. Repressed by darkness but induced by light. {ECO:0000269|PubMed:26961720}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankLN6818960.0LN681896.1 Cucumis melo genomic scaffold, anchoredscaffold00016.
GenBankLN7132640.0LN713264.1 Cucumis melo genomic chromosome, chr_10.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011655546.10.0PREDICTED: uncharacterized zinc finger protein At4g06634
SwissprotQ2V3L31e-155YY1_ARATH; Zinc finger transcription factor YY1
TrEMBLA0A0A0KT980.0A0A0A0KT98_CUCSA; Uncharacterized protein
STRINGXP_004161926.10.0(Cucumis sativus)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF56493354
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G06634.11e-141C2H2 family protein
Publications ? help Back to Top
  1. Kumekawa N,Hosouchi T,Tsuruoka H,Kotani H
    The size and sequence organization of the centromeric region of Arabidopsis thaliana chromosome 4.
    DNA Res., 2001. 8(6): p. 285-90
    [PMID:11853315]
  2. Ren Y, et al.
    An integrated genetic and cytogenetic map of the cucumber genome.
    PLoS ONE, 2009. 4(6): p. e5795
    [PMID:19495411]
  3. Guo S, et al.
    Transcriptome sequencing and comparative analysis of cucumber flowers with different sex types.
    BMC Genomics, 2010. 11: p. 384
    [PMID:20565788]
  4. Li Z, et al.
    RNA-Seq improves annotation of protein-coding genes in the cucumber genome.
    BMC Genomics, 2011. 12: p. 540
    [PMID:22047402]
  5. Li T,Wu XY,Li H,Song JH,Liu JY
    A Dual-Function Transcription Factor, AtYY1, Is a Novel Negative Regulator of the Arabidopsis ABA Response Network.
    Mol Plant, 2016. 9(5): p. 650-661
    [PMID:26961720]
  6. Wu XY,Li T
    A Casein Kinase II Phosphorylation Site in AtYY1 Affects Its Activity, Stability, and Function in the ABA Response.
    Front Plant Sci, 2017. 8: p. 323
    [PMID:28348572]