PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Camelina

Family

G2-like

Protein Properties

Length: 421aa MW: 46024.8 Da PI: 6.0533

Description

G2-like family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Csa12g020860.1	genome	CSGP	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	G2-like	94.8	6.5e-30	237	287	1	51
G2-like 1 kprlrWtpeLHerFveaveqLGGsekAtPktilelmkvkgLtlehvkSHLQ 51 k+r+rWtpeLHe+Fveav++LGGse+AtPk +l++mkv+gLt++hvkSHLQ Csa12g020860.1 237 KARMRWTPELHEAFVEAVNSLGGSERATPKGVLKIMKVEGLTIYHVKSHLQ 287 68************************************************* PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS51294	10.007	234	294	IPR017930	Myb domain
Gene3D	G3DSA:1.10.10.60	1.5E-26	236	287	IPR009057	Homeodomain-like
SuperFamily	SSF46689	2.69E-14	236	288	IPR009057	Homeodomain-like
TIGRFAMs	TIGR01557	4.1E-22	237	289	IPR006447	Myb domain, plants
Pfam	PF00249	9.3E-8	239	289	IPR001005	SANT/Myb domain
Pfam	PF14379	2.8E-24	324	367	IPR025756	MYB-CC type transcription factor, LHEQLE-containing domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 421 aa Download sequence Send to blast
MEARPVQRSG SRDLSSNNNL ARTSSIPSSS TPKPSAAEDV FMRSENNNTQ LMSRPLGQTY 60 HLLSSSNGGA VGHICSSSSS SGFSTNLHYS SMVSHEKQQH YTGNSSSNAA TVQTLSNDSS 120 WCHHGSLPGE FLDFPETHAA IQNSSHVEDG GIGAAFDDIQ KRSDWHDWAD HLITDEDPLL 180 STNWNDLLLE TSSNSDSKDQ KSLQIPQPQV VQQQPSPSVE LRPVSTTSSN SNNGTGKARM 240 RWTPELHEAF VEAVNSLGGS ERATPKGVLK IMKVEGLTIY HVKSHLQVLT NIFLPTHAAT 300 CSPEKKLTPL EHITSLDLKG GIGITEALRL QMEVQKQLHE QLEIQRNLQL RIEEQGKYLQ 360 MMFEKQNSGL TKGTASTSDS AAKSEQEDKK TADSKELAAE ETRVCEEPEA PQAKRPKTDN 420 *

Sequence ? help Back to Top

Protein Sequence Length: 421 aa Download sequence Send to blast

MEARPVQRSG SRDLSSNNNL ARTSSIPSSS TPKPSAAEDV FMRSENNNTQ LMSRPLGQTY  60
HLLSSSNGGA VGHICSSSSS SGFSTNLHYS SMVSHEKQQH YTGNSSSNAA TVQTLSNDSS  120
WCHHGSLPGE FLDFPETHAA IQNSSHVEDG GIGAAFDDIQ KRSDWHDWAD HLITDEDPLL  180
STNWNDLLLE TSSNSDSKDQ KSLQIPQPQV VQQQPSPSVE LRPVSTTSSN SNNGTGKARM  240
RWTPELHEAF VEAVNSLGGS ERATPKGVLK IMKVEGLTIY HVKSHLQVLT NIFLPTHAAT  300
CSPEKKLTPL EHITSLDLKG GIGITEALRL QMEVQKQLHE QLEIQRNLQL RIEEQGKYLQ  360
MMFEKQNSGL TKGTASTSDS AAKSEQEDKK TADSKELAAE ETRVCEEPEA PQAKRPKTDN  420
*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
6j4k_A	1e-28	236	287	1	52	Protein PHOSPHATE STARVATION RESPONSE 1
6j4k_B	1e-28	236	287	1	52	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_A	1e-28	236	287	1	52	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_C	1e-28	236	287	1	52	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_D	1e-28	236	287	1	52	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_F	1e-28	236	287	1	52	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_H	1e-28	236	287	1	52	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_J	1e-28	236	287	1	52	Protein PHOSPHATE STARVATION RESPONSE 1
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor involved in phosphate starvation signaling (PubMed:11511543, PubMed:17927693, PubMed:26586833). Binds as a dimer to P1BS, an imperfect palindromic sequence 5'-GNATATNC-3', to promote the expression of inorganic phosphate (Pi) starvation-responsive genes (PubMed:11511543, PubMed:20838596, PubMed:26586833). SPX1 is a competitive inhibitor of this DNA-binding (PubMed:25271326). PHR1 binding to its targets is low Pi-dependent (PubMed:25271326). Regulates the expression of miR399 (PubMed:20838596). Regulates the expression of IPS1 (At3g09922), a non-coding RNA that mimics the target of miR399 to block the cleavage of PHO2 under Pi-deficient conditions (PubMed:17643101). Regulates lipid remodeling and triacylglycerol accumulation during phosphorus starvation (PubMed:25680792). Required for the shoot-specific hypoxic response (PubMed:24753539). Regulates FER1 expression upon phosphate starvation, linking iron and phosphate homeostasis (PubMed:23788639). Contributes to the homeostasis of both sulfate and phosphate in plants under phosphate deficiency (PubMed:21261953). Required for adaptation to high light and retaining functional photosynthesis during phosphate starvation (PubMed:21910737). Involved in the coregulation of Zn and Pi homeostasis (PubMed:24420568). {ECO:0000269\|PubMed:11511543, ECO:0000269\|PubMed:17643101, ECO:0000269\|PubMed:17927693, ECO:0000269\|PubMed:20838596, ECO:0000269\|PubMed:21261953, ECO:0000269\|PubMed:21910737, ECO:0000269\|PubMed:23788639, ECO:0000269\|PubMed:24420568, ECO:0000269\|PubMed:24753539, ECO:0000269\|PubMed:25271326, ECO:0000269\|PubMed:25680792, ECO:0000269\|PubMed:26586833}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Csa12g020860.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Only moderately up-regulated by Pi starvation. {ECO:0000269\|PubMed:11511543}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AJ310799	0.0	AJ310799.1 Arabidopsis thaliana mRNA for phosphate starvation response regulator 1 (phr1 gene).
GenBank	JN009802	0.0	JN009802.1 UNVERIFIED: Lupinus polyphyllus phosphate starvation response regulator-like mRNA, complete sequence.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_010447949.1	0.0	PREDICTED: protein PHOSPHATE STARVATION RESPONSE 1
Swissprot	Q94CL7	0.0	PHR1_ARATH; Protein PHOSPHATE STARVATION RESPONSE 1
TrEMBL	A0A178UXC9	0.0	A0A178UXC9_ARATH; PHR1
STRING	XP_010447949.1	0.0	(Camelina sativa)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM856	27	117

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT4G28610.1	0.0	phosphate starvation response 1

Publications ? help Back to Top
Duarte JM, et al. Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. Mol. Biol. Evol., 2006. 23(2): p. 469-78 [PMID:16280546] Matsui K,Togami J,Mason JG,Chandler SF,Tanaka Y Enhancement of phosphate absorption by garden plants by genetic engineering: a new tool for phytoremediation. Biomed Res Int, 2013. 2013: p. 182032 [PMID:23984322] Jost R, et al. Differentiating phosphate-dependent and phosphate-independent systemic phosphate-starvation response networks in Arabidopsis thaliana through the application of phosphite. J. Exp. Bot., 2015. 66(9): p. 2501-14 [PMID:25697796] Zhou Z, et al. SPX proteins regulate Pi homeostasis and signaling in different subcellular level. Plant Signal Behav, 2015. 10(9): p. e1061163 [PMID:26224365] Bonnot C, et al. A chemical genetic strategy identify the PHOSTIN, a synthetic molecule that triggers phosphate starvation responses in Arabidopsis thaliana. New Phytol., 2016. 209(1): p. 161-76 [PMID:26243630] Khan GA,Vogiatzaki E,Glauser G,Poirier Y Phosphate Deficiency Induces the Jasmonate Pathway and Enhances Resistance to Insect Herbivory. Plant Physiol., 2016. 171(1): p. 632-44 [PMID:27016448] Velasco VM, et al. Acclimation of the crucifer Eutrema salsugineum to phosphate limitation is associated with constitutively high expression of phosphate-starvation genes. Plant Cell Environ., 2016. 39(8): p. 1818-34 [PMID:27038434] Yong-Villalobos L, et al. Phosphate starvation induces DNA methylation in the vicinity of cis-acting elements known to regulate the expression of phosphate-responsive genes. Plant Signal Behav, 2016. 11(5): p. e1173300 [PMID:27185363] Li Y,Wu H,Fan H,Zhao T,Ling HQ Characterization of the AtSPX3 Promoter Elucidates its Complex Regulation in Response to Phosphorus Deficiency. Plant Cell Physiol., 2016. 57(8): p. 1767-78 [PMID:27382128] Zhang H,Huang L,Hong Y,Song F BOTRYTIS-INDUCED KINASE1, a plasma membrane-localized receptor-like protein kinase, is a negative regulator of phosphate homeostasis in Arabidopsis thaliana. BMC Plant Biol., 2016. 16(1): p. 152 [PMID:27389008] Yuan J, et al. Systematic characterization of novel lncRNAs responding to phosphate starvation in Arabidopsis thaliana. BMC Genomics, 2016. 17: p. 655 [PMID:27538394] Linn J, et al. Root Cell-Specific Regulators of Phosphate-Dependent Growth. Plant Physiol., 2017. 174(3): p. 1969-1989 [PMID:28465462] Aleksza D,Horváth GV,Sándor G,Szabados L Proline Accumulation Is Regulated by Transcription Factors Associated with Phosphate Starvation. Plant Physiol., 2017. 175(1): p. 555-567 [PMID:28765275] Liu Y, et al. Light and Ethylene Coordinately Regulate the Phosphate Starvation Response through Transcriptional Regulation of PHOSPHATE STARVATION RESPONSE1. Plant Cell, 2017. 29(9): p. 2269-2284 [PMID:28842534] Qi W,Manfield IW,Muench SP,Baker A AtSPX1 affects the AtPHR1-DNA-binding equilibrium by binding monomeric AtPHR1 in solution. Biochem. J., 2017. 474(21): p. 3675-3687 [PMID:28887383] Huang KL, et al. The ARF7 and ARF19 Transcription Factors Positively Regulate PHOSPHATE STARVATION RESPONSE1 in Arabidopsis Roots. Plant Physiol., 2018. 178(1): p. 413-427 [PMID:30026290] Jiang M, et al. Structural basis for the Target DNA recognition and binding by the MYB domain of phosphate starvation response 1. FEBS J., 2019. [PMID:30974511]