PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Camelina

Family

GRF

Protein Properties

Length: 556aa MW: 61111.4 Da PI: 9.3044

Description

GRF family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Csa12g003640.1	genome	CSGP	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	WRC	78.4	6.7e-25	234	277	1	44
WRC 1 daepgrCrRtDGKkWRCsrrvlegkklCErHlhrgrsrsrkske 44 d+epgrCrRtDGKkWRCsr++++++k+CErH++rgr+rsrk++e Csa12g003640.1 234 DPEPGRCRRTDGKKWRCSRDAVPDQKYCERHINRGRHRSRKPVE 277 79***************************************998 PP
2	QLQ	52	2.2e-18	170	205	1	36
QLQ 1 saFTaaQlqlLksQilAyKyLaanqPvPpeLlqaiq 36 ++FT +Q+++L++Q+l+yKy+ an+PvP+ Ll ++ Csa12g003640.1 170 GPFTLTQWAELEQQALIYKYITANVPVPSSLLISLK 205 59*****************************98876 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SMART	SM00951	5.6E-11	170	206	IPR014978	Glutamine-Leucine-Glutamine, QLQ
Pfam	PF08880	1.4E-12	171	203	IPR014978	Glutamine-Leucine-Glutamine, QLQ
PROSITE profile	PS51666	20.844	171	206	IPR014978	Glutamine-Leucine-Glutamine, QLQ
PROSITE profile	PS51667	25.77	234	278	IPR014977	WRC domain
Pfam	PF08879	3.6E-21	235	277	IPR014977	WRC domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0008285	Biological Process	negative regulation of cell proliferation
GO:0048364	Biological Process	root development
GO:0048366	Biological Process	leaf development
GO:0005634	Cellular Component	nucleus
GO:0005524	Molecular Function	ATP binding

Sequence ? help Back to Top
Protein Sequence Length: 556 aa Download sequence Send to blast
MDIGVHILGS VTSNETPGGQ KQELRVGTKQ DRSGFNGDDY YLQRTLKLAR TTAATREEEE 60 DNLSSSSSFA AASYCKTMPF HQGIPLLRSN SPLDSRRQEQ MLSFSDKPEA LDFTKYVGLD 120 NNCNNKSSLS PFLHHIPPPS YFRNSGGGYG SGGMMMNMMS MQGNFTSVKG PFTLTQWAEL 180 EQQALIYKYI TANVPVPSSL LISLKKSFYP FGSLPPSSFG WGSFHLGFAG GNMDPEPGRC 240 RRTDGKKWRC SRDAVPDQKY CERHINRGRH RSRKPVEVQS GQTATAATKA VTTTPQQPVV 300 TGNSNNRRAS NSNRSLAIGG GQYINPSTES LPNNNRVRNP QIYPSTVNLQ PKESPVIHQK 360 HRNNNNNNNP FEFGHISSDS LLNPNANTSK TYGSSFLDFS SNQDKYSGNH NHNSWPEELK 420 SDWTQLSMSI PIASTSPSFS HNNNNNNNNA QDKTTLSPLR LSREIDLSIQ TEETTIEPAA 480 KKVNTWIPIS WGNSLGGPLG EVLNSTTNSP TLGSSPTGVL QKSTFCSLSN NSSVSSPIAE 540 NNNRNNGDYF HYTTT*

Sequence ? help Back to Top

Protein Sequence Length: 556 aa Download sequence Send to blast

MDIGVHILGS VTSNETPGGQ KQELRVGTKQ DRSGFNGDDY YLQRTLKLAR TTAATREEEE  60
DNLSSSSSFA AASYCKTMPF HQGIPLLRSN SPLDSRRQEQ MLSFSDKPEA LDFTKYVGLD  120
NNCNNKSSLS PFLHHIPPPS YFRNSGGGYG SGGMMMNMMS MQGNFTSVKG PFTLTQWAEL  180
EQQALIYKYI TANVPVPSSL LISLKKSFYP FGSLPPSSFG WGSFHLGFAG GNMDPEPGRC  240
RRTDGKKWRC SRDAVPDQKY CERHINRGRH RSRKPVEVQS GQTATAATKA VTTTPQQPVV  300
TGNSNNRRAS NSNRSLAIGG GQYINPSTES LPNNNRVRNP QIYPSTVNLQ PKESPVIHQK  360
HRNNNNNNNP FEFGHISSDS LLNPNANTSK TYGSSFLDFS SNQDKYSGNH NHNSWPEELK  420
SDWTQLSMSI PIASTSPSFS HNNNNNNNNA QDKTTLSPLR LSREIDLSIQ TEETTIEPAA  480
KKVNTWIPIS WGNSLGGPLG EVLNSTTNSP TLGSSPTGVL QKSTFCSLSN NSSVSSPIAE  540
NNNRNNGDYF HYTTT*

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that plays a role in the regulation of cell expansion in leaf and cotyledons tissues. Component of a network formed by miR396, the GRFs and their interacting factors (GIFs) acting in the regulation of meristem function, at least partially through the control of cell proliferation. {ECO:0000269\|PubMed:12974814, ECO:0000269\|PubMed:15326298, ECO:0000269\|PubMed:20023165, ECO:0000269\|PubMed:21036927}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Csa12g003640.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: microRNA 396 (miR396a or miR396b) negatively regulates growth-regulating factors (GRF1-4 and GRF7-9). {ECO:0000269\|PubMed:15200956, ECO:0000269\|PubMed:19453503, ECO:0000269\|PubMed:20023165}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_010446629.1	0.0	PREDICTED: growth-regulating factor 2
Swissprot	Q8L8A8	0.0	GRF2_ARATH; Growth-regulating factor 2
TrEMBL	A0A178UXW8	0.0	A0A178UXW8_ARATH; GRF2
STRING	XP_010446629.1	0.0	(Camelina sativa)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM1454	28	86

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT4G37740.1	0.0	growth-regulating factor 2

Publications ? help Back to Top
Casadevall R,Rodriguez RE,Debernardi JM,Palatnik JF,Casati P Repression of growth regulating factors by the microRNA396 inhibits cell proliferation by UV-B radiation in Arabidopsis leaves. Plant Cell, 2013. 25(9): p. 3570-83 [PMID:24076976] Liu J,Rice JH,Chen N,Baum TJ,Hewezi T Synchronization of developmental processes and defense signaling by growth regulating transcription factors. PLoS ONE, 2014. 9(5): p. e98477 [PMID:24875638] Cao Y,Han Y,Jin Q,Lin Y,Cai Y Comparative Genomic Analysis of the GRF Genes in Chinese Pear (Pyrus bretschneideri Rehd), Poplar (Populous), Grape (Vitis vinifera), Arabidopsis and Rice (Oryza sativa). Front Plant Sci, 2016. 7: p. 1750 [PMID:27933074]