PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Camelina

Family

GRF

Protein Properties

Length: 535aa MW: 57113.9 Da PI: 9.5671

Description

GRF family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Csa09g087120.1	genome	CSGP	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	WRC	78.2	7.7e-25	202	246	1	45
WRC 1 daepgrCrRtDGKkWRCsrrvlegkklCErHlhrgrsrsrkskee 45 d+epgrCrRtDGKkWRCsr++++++k+CErH++rgr+rsrk++e Csa09g087120.1 202 DPEPGRCRRTDGKKWRCSRDAVPDQKYCERHINRGRHRSRKPVEG 246 79****************************************985 PP
2	QLQ	51.5	3.1e-18	138	174	1	37
QLQ 1 saFTaaQlqlLksQilAyKyLaanqPvPpeLlqaiqk 37 ++F+ +Q+++L++Q+l+yKy+ an+PvP+ Ll+ ++k Csa09g087120.1 138 GPFSLTQWAELEQQALIYKYITANVPVPSSLLLSLKK 174 59******************************99875 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SMART	SM00951	1.3E-10	138	174	IPR014978	Glutamine-Leucine-Glutamine, QLQ
PROSITE profile	PS51666	20.723	139	174	IPR014978	Glutamine-Leucine-Glutamine, QLQ
Pfam	PF08880	2.2E-12	139	171	IPR014978	Glutamine-Leucine-Glutamine, QLQ
PROSITE profile	PS51667	25.954	202	246	IPR014977	WRC domain
Pfam	PF08879	3.5E-21	203	245	IPR014977	WRC domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0005524	Molecular Function	ATP binding

Sequence ? help Back to Top
Protein Sequence Length: 535 aa Download sequence Send to blast
MDLGVRVSSH ETGSSPPGQT ELGSGFINNN KQERSGFDGE DCWRSSKLSR TSSTTDGFSS 60 SSTSAAAKTL SFHQGIPLLR STTIDPRRGQ EHMLSFSSAS DKSDVSPYLQ YCRNSGYGLG 120 GMMNTSSMHG NLLTGVKGPF SLTQWAELEQ QALIYKYITA NVPVPSSLLL SLKKSFFPYG 180 SLPPNSFGWG SFHLGFSGGN MDPEPGRCRR TDGKKWRCSR DAVPDQKYCE RHINRGRHRS 240 RKPVEGQNGH NTNAAAASAA ASTAASVSKA AGTSAVAAMR GLDNVNNSLA AAVRTHHHAN 300 TNQSTDSLAT RVQNSRAASV FPTAMNLQQK DPHPKQTNNN NPFEFGLISS DSLLNPSHKQ 360 ASYGNSSKGF GSYLDFSNQA KHSGNHNNDD SWPEELKSDW TQLSMSIPMA PSSPVQDNKL 420 PLSPLRLSRE FDLGLGVNTE FLEPGKKANN WIPISWGNNN SMGGPLGEVL NSTTNSPKFG 480 SSPTGVLQKS TFGSLSNSSS GSSTVIGDNN NKNGDGKDPL GPTTLMNTSA TAPL*

Sequence ? help Back to Top

Protein Sequence Length: 535 aa Download sequence Send to blast

MDLGVRVSSH ETGSSPPGQT ELGSGFINNN KQERSGFDGE DCWRSSKLSR TSSTTDGFSS  60
SSTSAAAKTL SFHQGIPLLR STTIDPRRGQ EHMLSFSSAS DKSDVSPYLQ YCRNSGYGLG  120
GMMNTSSMHG NLLTGVKGPF SLTQWAELEQ QALIYKYITA NVPVPSSLLL SLKKSFFPYG  180
SLPPNSFGWG SFHLGFSGGN MDPEPGRCRR TDGKKWRCSR DAVPDQKYCE RHINRGRHRS  240
RKPVEGQNGH NTNAAAASAA ASTAASVSKA AGTSAVAAMR GLDNVNNSLA AAVRTHHHAN  300
TNQSTDSLAT RVQNSRAASV FPTAMNLQQK DPHPKQTNNN NPFEFGLISS DSLLNPSHKQ  360
ASYGNSSKGF GSYLDFSNQA KHSGNHNNDD SWPEELKSDW TQLSMSIPMA PSSPVQDNKL  420
PLSPLRLSRE FDLGLGVNTE FLEPGKKANN WIPISWGNNN SMGGPLGEVL NSTTNSPKFG  480
SSPTGVLQKS TFGSLSNSSS GSSTVIGDNN NKNGDGKDPL GPTTLMNTSA TAPL*

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that plays a role in the regulation of cell expansion in leaf and cotyledons tissues. Component of a network formed by miR396, the GRFs and their interacting factors (GIFs) acting in the regulation of meristem function, at least partially through the control of cell proliferation. microRNA396-GRF1/GRF3 regulatory module acts as a developmental regulator in the reprogramming of root cells during cyst nematode infection, leading to the formation of the syncytium. {ECO:0000269\|PubMed:12974814, ECO:0000269\|PubMed:15326298, ECO:0000269\|PubMed:22419826, ECO:0000269\|PubMed:22751317}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Csa09g087120.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: microRNA 396 (miR396a or miR396b) negatively regulates growth-regulating factors (GRF1-4 and GRF7-9). Up-regulated in response to cyst nematode infection. {ECO:0000269\|PubMed:15200956, ECO:0000269\|PubMed:19453503, ECO:0000269\|PubMed:20023165, ECO:0000269\|PubMed:22419826}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AB493560	0.0	AB493560.1 Arabidopsis thaliana At2g22840 mRNA for hypothetical protein, partial cds, clone: RAAt2g22840.
GenBank	AY102634	0.0	AY102634.1 Arabidopsis thaliana transcription activator (GRF1) mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_010472281.1	0.0	PREDICTED: growth-regulating factor 1
Swissprot	O81001	0.0	GRF1_ARATH; Growth-regulating factor 1
TrEMBL	A0A178VNQ3	0.0	A0A178VNQ3_ARATH; GRF1
STRING	XP_010472281.1	0.0	(Camelina sativa)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM1454	28	86

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G22840.1	0.0	growth-regulating factor 1

Publications ? help Back to Top
Casadevall R,Rodriguez RE,Debernardi JM,Palatnik JF,Casati P Repression of growth regulating factors by the microRNA396 inhibits cell proliferation by UV-B radiation in Arabidopsis leaves. Plant Cell, 2013. 25(9): p. 3570-83 [PMID:24076976] Liu J,Rice JH,Chen N,Baum TJ,Hewezi T Synchronization of developmental processes and defense signaling by growth regulating transcription factors. PLoS ONE, 2014. 9(5): p. e98477 [PMID:24875638] Cao Y,Han Y,Jin Q,Lin Y,Cai Y Comparative Genomic Analysis of the GRF Genes in Chinese Pear (Pyrus bretschneideri Rehd), Poplar (Populous), Grape (Vitis vinifera), Arabidopsis and Rice (Oryza sativa). Front Plant Sci, 2016. 7: p. 1750 [PMID:27933074]